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  1. High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of ...

    Authors: Paolo A Ascierto, Maria Napolitano, Egidio Celentano, Ester Simeone, Giusy Gentilcore, Antonio Daponte, Mariaelena Capone, Corrado Caracò, Rosa Calemma, Gerardo Beneduce, Margherita Cerrone, Vincenzo De Rosa, Giuseppe Palmieri, Giuseppe Castello, John M Kirkwood, Francesco M Marincola…
    Citation: Journal of Translational Medicine 2010 8:76
  2. The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical example...

    Authors: Wan-Zhang Yang, Yun Zhang, Fang Wu, Wei-Ping Min, Boris Minev, Min Zhang, Xiao-Ling Luo, Famela Ramos, Thomas E Ichim, Neil H Riordan and Xiang Hu
    Citation: Journal of Translational Medicine 2010 8:75
  3. Familial Amyloidotic Polyneuropathy (FAP) is a disorder characterized by the extracellular deposition of fibrillar Transthyretin (TTR) amyloid, with a special involvement of the peripheral nerve. We had previo...

    Authors: Isabel Cardoso, Diana Martins, Tania Ribeiro, Giampaolo Merlini and Maria João Saraiva
    Citation: Journal of Translational Medicine 2010 8:74
  4. Rapid progression of residual tumor after radiofrequency ablation (RFA) of hepatocellular carcinoma has been observed increasingly. However, its underlying mechanisms remain to be clarified. The present study ...

    Authors: Shan Ke, Xue-mei Ding, Jian Kong, Jun Gao, Shao-hong Wang, Yan Cheng and Wen-bing Sun
    Citation: Journal of Translational Medicine 2010 8:73
  5. EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated r...

    Authors: Britta Wahren, Priscilla Biswas, Marie Borggren, Adam Coleman, Kelly Da Costa, Winni De Haes, Tessa Dieltjens, Stefania Dispinseri, Katrijn Grupping, David Hallengärd, Julia Hornig, Katja Klein, Lara Mainetti, Paolo Palma, Marc Reudelsterz, Janna Seifried…
    Citation: Journal of Translational Medicine 2010 8:72

    The Erratum to this article has been published in Journal of Translational Medicine 2010 8:82

  6. IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We report clinical and biological r...

    Authors: Chrystelle Brignone, Maya Gutierrez, Fawzia Mefti, Etienne Brain, Rosana Jarcau, Frédérique Cvitkovic, Nabil Bousetta, Jacques Medioni, Joseph Gligorov, Caroline Grygar, Manon Marcu and Frédéric Triebel
    Citation: Journal of Translational Medicine 2010 8:71
  7. The goal of our study was to investigate the molecular underpinnings associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African American (AA) compared to Caucasian American...

    Authors: Amy E Rose, Jaya M Satagopan, Carole Oddoux, Qin Zhou, Ruliang Xu, Adam B Olshen, Jessie Z Yu, Atreya Dash, Jerome Jean-Gilles, Victor Reuter, William L Gerald, Peng Lee and Iman Osman
    Citation: Journal of Translational Medicine 2010 8:70
  8. MiR arrays distinguish themselves from gene expression arrays by their more limited number of probes, and the shorter and less flexible sequence in probe design. Robust data processing and analysis methods tai...

    Authors: Yingdong Zhao, Ena Wang, Hui Liu, Melissa Rotunno, Jill Koshiol, Francesco M Marincola, Maria Teresa Landi and Lisa M McShane
    Citation: Journal of Translational Medicine 2010 8:69
  9. The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences dep...

    Authors: Sándor Szalma, Venkata Koka, Tatiana Khasanova and Eric D Perakslis
    Citation: Journal of Translational Medicine 2010 8:68
  10. Activating mutations in BRAF kinase are common in melanomas. Clinical trials with PLX4032, the mutant-BRAF inhibitor, show promising preliminary results in patients selected for the presence of V600E mutation....

    Authors: Jill C Rubinstein, Mario Sznol, Anna C Pavlick, Stephan Ariyan, Elaine Cheng, Antonella Bacchiocchi, Harriet M Kluger, Deepak Narayan and Ruth Halaban
    Citation: Journal of Translational Medicine 2010 8:67
  11. The proteomics approach termed proteome pattern analysis has been shown previously to have potential in the detection and classification of breast cancer. Here we aimed to identify changes in serum proteome pa...

    Authors: Monika Pietrowska, Joanna Polanska, Lukasz Marczak, Katarzyna Behrendt, Elzbieta Nowicka, Maciej Stobiecki, Andrzej Polanski, Rafal Tarnawski and Piotr Widlak
    Citation: Journal of Translational Medicine 2010 8:66
  12. Americans see clinical research as important, with over 15 million American residents participating in NIH-sponsored studies in 2008 and growing yearly.

    Authors: Robert B Nussenblatt and Curtis L Meinert
    Citation: Journal of Translational Medicine 2010 8:65
  13. Angiotensin and serotonin have been identified as inducers of cardiac hypertrophy. DNA polymorphisms at the genes encoding components of the angiotensin and serotonin systems have been associated with the risk...

    Authors: Eliecer Coto, María Palacín, María Martín, Mónica G Castro, Julián R Reguero, Cristina García, José R Berrazueta, César Morís, Blanca Morales, Francisco Ortega, Ana I Corao, Marta Díaz, Beatriz Tavira and Victoria Alvarez
    Citation: Journal of Translational Medicine 2010 8:64
  14. The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated.

    Authors: Steve Leu, Yu-Chun Lin, Chun-Man Yuen, Chia-Hung Yen, Ying-Hsien Kao, Cheuk-Kwan Sun and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2010 8:63
  15. Changes in clinical practice are brought about by the weight of clinical evidence for and against an intervention. Clinical evidence of efficacy relies on the dissemination of research results, usually by publ...

    Authors: Lisa J Douet, Danielle Preedy, Vaughan Thomas and Ian A Cree
    Citation: Journal of Translational Medicine 2010 8:62
  16. Pancreatic cancer has a high mortality rate because it is usually diagnosed when metastasis have already occurred (microscopic and gross disease). Ezrin plays important roles in cell motility, invasion and tum...

    Authors: Yunxiao Meng, Zhaohui Lu, Shuangni Yu, Qiang Zhang, Yihui Ma and Jie Chen
    Citation: Journal of Translational Medicine 2010 8:61
  17. This manuscript reports the production and preclinical studies to examine the tolerance and efficacy of an autologous cellular gel-matrix integrated implant system (IIS) aimed to treat full-thickness skin lesi...

    Authors: Caroline R Weinstein-Oppenheimer, Alexis R Aceituno, Donald I Brown, Cristian Acevedo, Ricardo Ceriani, Miguel A Fuentes, Fernando Albornoz, Carlos F Henríquez-Roldán, Patricio Morales, Claudio Maclean, Sergio M Tapia and Manuel E Young
    Citation: Journal of Translational Medicine 2010 8:59
  18. Cancer remains a leading cause of death in the world today. Despite decades of research to identify novel therapeutic approaches, durable regressions of metastatic disease are still scanty and survival benefit...

    Authors: Veronica Huber, Angelo De Milito, Salvador Harguindey, Stephan J Reshkin, Miriam L Wahl, Cyril Rauch, Antonio Chiesi, Jacques Pouysségur, Robert A Gatenby, Licia Rivoltini and Stefano Fais
    Citation: Journal of Translational Medicine 2010 8:57
  19. Cutaneous melanoma is a very aggressive neoplasia of melanocytic origin with constantly growing incidence and mortality rates world-wide. Epigenetic modifications (i.e., alterations of genomic DNA methylation ...

    Authors: Luca Sigalotti, Alessia Covre, Elisabetta Fratta, Giulia Parisi, Francesca Colizzi, Aurora Rizzo, Riccardo Danielli, Hugues JM Nicolay, Sandra Coral and Michele Maio
    Citation: Journal of Translational Medicine 2010 8:56
  20. While adjuvant immunotherapy with Bacille Calmette Guérin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK) are...

    Authors: Maximilian Burger, Nicolas Thiounn, Stefan Denzinger, Jozsef Kondas, Gerard Benoit, Manuel S Chapado, Fernando J Jimenz-Cruz, Laszlo Kisbenedek, Zoltán Szabo, Domján Zsolt, Marc O Grimm, Imre Romics, Joachim W Thüroff, Tamas Kiss, Bertrand Tombal, Manfred Wirth…
    Citation: Journal of Translational Medicine 2010 8:54
  21. Adjuvant trastuzumab (Herceptin) treatment of breast cancer patients significantly improves their clinical outcome. Vaccination is an attractive alternative approach to provide HER-2/neu (Her2)-specific antibo...

    Authors: Håkan Norell, Isabel Poschke, Jehad Charo, Wei Z Wei, Courtney Erskine, Marie P Piechocki, Keith L Knutson, Jonas Bergh, Elisabet Lidbrink and Rolf Kiessling
    Citation: Journal of Translational Medicine 2010 8:53
  22. Antigen processing by dendritic cells (DC) exposed to specific stimuli has been well characterized in biological studies. Nonetheless, the question of whether autologous whole tumor lysates (as used in clinica...

    Authors: Laura Fiammenghi, Valentina Ancarani, Tilman Rosales, Jay R Knutson, Massimiliano Petrini, Anna Maria Granato, Elena Pancisi, Laura Ridolfi, Ruggero Ridolfi, Angela Riccobon and Paolo Neyroz
    Citation: Journal of Translational Medicine 2010 8:52
  23. In preparation for potential clinical development of Ab-01, an antagonistic antibody directed against the IL21R, studies were undertaken to address translational medicine needs that fall into four categories: ...

    Authors: Maya Arai, Sadhana Jain, Amy A Weaver, Andrew A Hill, Yongjing Guo, Andrea G Bree, Michael F Smith Jr, Scott W Allen, Edward R LaVallie, Deborah Young, Laird Bloom, Karissa Adkins and Margot O'Toole
    Citation: Journal of Translational Medicine 2010 8:51
  24. Selective neutralization of the IL21/IL21R signaling pathway is a promising approach for the treatment of a variety of autoimmune diseases. Ab-01 is a human neutralizing anti-IL21R antibody. In order to ensure...

    Authors: Yongjing Guo, Andrew A Hill, Renee C Ramsey, Frederick W Immermann, Christopher Corcoran, Deborah Young, Edward R LaVallie, Mark Ryan, Theresa Bechard, Richard Pfeifer, Garvin Warner, Marcia Bologna, Laird Bloom and Margot O'Toole
    Citation: Journal of Translational Medicine 2010 8:50
  25. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and play a crucial role in the host's innate immune response. Genetic variations in TLR genes may influence host-viral interactions a...

    Authors: Elisabetta Ricci, Sandro Malacrida, Marisa Zanchetta, Ilaria Mosconi, Marco Montagna, Carlo Giaquinto and Anita De Rossi
    Citation: Journal of Translational Medicine 2010 8:49
  26. MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle rege...

    Authors: Stefano Gambardella, Fabrizio Rinaldi, Saverio M Lepore, Antonella Viola, Emanuele Loro, Corrado Angelini, Lodovica Vergani, Giuseppe Novelli and Annalisa Botta
    Citation: Journal of Translational Medicine 2010 8:48
  27. T-cell immunodeficiency is a common feature in cancer patients, which may relate to initiation and development of tumor. Based on our previous finding, to further characterize the immune status, T cell prolife...

    Authors: Yangqiu Li, Suxia Geng, Qingsong Yin, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Xin Du, Christian A Schmidt and Grzegorz K Przybylski
    Citation: Journal of Translational Medicine 2010 8:47
  28. Ischaemic preconditioning (IPC) has emerged as a method of reducing ischaemia-reperfusion injury. However, the complex mechanism through which IPC elicits this protection is not fully understood. The aim of th...

    Authors: Terence Murphy, Pauline M Walsh, Peter P Doran and Kevin J Mulhall
    Citation: Journal of Translational Medicine 2010 8:46
  29. CCL20 and its receptor CCR6 have been shown to play a role in the onset, development and metastatic spread of various gastrointestinal malignancies. In this study, the expression profile and clinical significa...

    Authors: Claudia Rubie, Vilma Oliveira Frick, Pirus Ghadjar, Mathias Wagner, Henner Grimm, Benjamin Vicinus, Christoph Justinger, Stefan Graeber and Martin K Schilling
    Citation: Journal of Translational Medicine 2010 8:45
  30. E1B55kD deleted oncolytic adenovirus was designed to achieve cancer-specific cytotoxicity, but showed limitations in clinical study. To find a method to increase its efficacy, we investigated the correlation b...

    Authors: Cheng Wang, Zhehao Dai, Rong Fan, Youwen Deng, Guohua Lv and Guangxiu Lu
    Citation: Journal of Translational Medicine 2010 8:44
  31. Photodynamic therapy (PDT) involves excitation of sensitizer molecules by visible light in the presence of molecular oxygen, thereby generating reactive oxygen species (ROS) through electron/energy transfer pr...

    Authors: Seema Gupta, Bilikere S Dwarakanath, K Muralidhar, Tulay Koru-Sengul and Viney Jain
    Citation: Journal of Translational Medicine 2010 8:43
  32. Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist an...

    Authors: Jennifer A Westwood, Phillip K Darcy, Preethi Mayura Guru, Janelle Sharkey, Hollie J Pegram, Sally M Amos, Mark J Smyth and Michael H Kershaw
    Citation: Journal of Translational Medicine 2010 8:42
  33. Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antib...

    Authors: Yulia Vugmeyster, Scott Allen, Pamela Szklut, Andrea Bree, Mark Ryan, Margery Ma, Vikki Spaulding, Deborah Young, Heath Guay, Laird Bloom, Michael W Leach, Margot O'Toole and Karissa Adkins
    Citation: Journal of Translational Medicine 2010 8:41
  34. Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-...

    Authors: Antonia Radaelli, Eleana Pozzi, Sole Pacchioni, Carlo Zanotto and Carlo De Giuli Morghen
    Citation: Journal of Translational Medicine 2010 8:40
  35. Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in m...

    Authors: Jonas N Søndergaard, Ramin Nazarian, Qi Wang, Deliang Guo, Teli Hsueh, Stephen Mok, Hooman Sazegar, Laura E MacConaill, Jordi G Barretina, Sarah M Kehoe, Narsis Attar, Erika von Euw, Jonathan E Zuckerman, Bartosz Chmielowski, Begoña Comin-Anduix, Richard C Koya…
    Citation: Journal of Translational Medicine 2010 8:39
  36. Treatment for both early and advanced melanoma has changed little since the introduction of interferon and IL-2 in the early 1990s. Recent data from trials testing targeted agents or immune modulators suggest ...

    Authors: Paolo A Ascierto, Howard Z Streicher and Mario Sznol
    Citation: Journal of Translational Medicine 2010 8:38
  37. NSC-741909 is a novel anticancer agent that can effectively suppress the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers. We recently showed that NSC-741909-induced a...

    Authors: Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu and Bingliang Fang
    Citation: Journal of Translational Medicine 2010 8:37
  38. Responsiveness to Cetuximab alone can be mediated by an increase of Epidermal Growth factor Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in advanced colorectal c...

    Authors: Carla Campanella, Marcella Mottolese, Anna Cianciulli, Angela Torsello, Roberta Merola, Isabella Sperduti, Elisa Melucci, Salvatore Conti, Maria Grazia Diodoro, Massimo Zeuli, Giancarlo Paoletti, Francesco Cognetti and Carlo Garufi
    Citation: Journal of Translational Medicine 2010 8:36
  39. Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in var...

    Authors: Sebastian Ochsenreither, Alberto Fusi, Susanne Wojtke, Antonia Busse, Natascha C Nüssler, Eckhard Thiel, Ulrich Keilholz and Dirk Nagorsen
    Citation: Journal of Translational Medicine 2010 8:35
  40. The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in pr...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Famela Ramos, Thomas E Ichim and Neil H Riordan
    Citation: Journal of Translational Medicine 2010 8:34
  41. In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia.

    Authors: Michaela Muth, Katharina Theophile, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock
    Citation: Journal of Translational Medicine 2010 8:33
  42. The oncoprotein Epstain-Barr Virus (EBV)-encoded latent membrane protein1 (LMP1) modulates the pathological effects of the NF-κB, AP-1 and JAK/STAT pathways in nasopharyngeal carcinoma (NPC).

    Authors: Jing Chen, Chun-Fang Hu, Jing-Hui Hou, Qiong Shao, Li-Xu Yan, Xiao-Feng Zhu, Yi-Xin Zeng and Jian-Yong Shao
    Citation: Journal of Translational Medicine 2010 8:30
  43. Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for treatment of abdominal malignancy. Nonetheless, the interactions between radiation and 5-FU remain unclear. We evaluated the influenc...

    Authors: Chen-Hsi Hsieh, Yen-Ju Hsieh, Chia-Yuan Liu, Hung-Chi Tai, Yu-Chuen Huang, Pei-Wei Shueng, Le-Jung Wu, Li-Ying Wang, Tung-Hu Tsai and Yu-Jen Chen
    Citation: Journal of Translational Medicine 2010 8:29
  44. Current vaccines against HPVs are constituted of L1 protein self-assembled into virus-like particles (VLPs) and they have been shown to protect against natural HPV16 and HPV18 infections and associated lesions...

    Authors: Nicolas Combelas, Emilie Saussereau, Maxime JJ Fleury, Tatiana Ribeiro, Julien Gaitan, Diego F Duarte-Forero, Pierre Coursaget and Antoine Touzé
    Citation: Journal of Translational Medicine 2010 8:28
  45. This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli
    Citation: Journal of Translational Medicine 2010 8:27

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