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  1. Clear cell renal cell carcinoma (ccRCC) represents the most invasive and common adult kidney neoplasm. Mounting evidence suggests that microRNAs (miRNAs) are important regulators of gene expression. But their ...

    Authors: Jiajia Chen, Daqing Zhang, Wenyu Zhang, Yifei Tang, Wenying Yan, Lingchuan Guo and Bairong Shen
    Citation: Journal of Translational Medicine 2013 11:169
  2. Patient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) xen...

    Authors: Xu-chao Zhang, Jingchuan Zhang, Ming Li, Xiao-sui Huang, Xue-ning Yang, Wen-zhao Zhong, Liang Xie, Lin Zhang, Minhua Zhou, Paul Gavine, Xinying Su, Li Zheng, Guanshan Zhu, Ping Zhan, Qunsheng Ji and Yi-long Wu
    Citation: Journal of Translational Medicine 2013 11:168
  3. Estrogens were recently demonstrated to be synthesized in non-small cell lung carcinomas (NSCLCs) via aromatase activity and aromatase inhibitor (AI) did suppressed estrogen receptor (ER) positive NSCLC growth. H...

    Authors: Mohit K Verma, Yasuhiro Miki, Keiko Abe, Takashi Suzuki, Hiromichi Niikawa, Satoshi Suzuki, Takashi Kondo and Hironobu Sasano
    Citation: Journal of Translational Medicine 2013 11:167
  4. mRNA electroporation of dendritic cells (DCs) facilitates processing and presentation of multiple peptides derived from whole antigen, tailored to different HLA molecules. Clinical responses to electroporated ...

    Authors: David J Chung, Emanuela Romano, Katherine B Pronschinske, Justin A Shyer, Milena Mennecozzi, Erin T St Angelo and James W Young
    Citation: Journal of Translational Medicine 2013 11:166
  5. Trimeric soluble forms of HIV gp140 envelope glycoproteins represent one of the closest molecular structures compared to native spikes present on intact virus particles. Trimeric soluble gp140 have been genera...

    Authors: Maria Luisa Visciano, Maria Tagliamonte, Guillaume Stewart-Jones, Leo Heyndrickx, Guido Vanham, Marianne Jansson, Anders Fomsgaard, Berit Grevstad, Meghna Ramaswamy, Franco M Buonaguro, Maria Lina Tornesello, Priscilla Biswas, Gabriella Scarlatti and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2013 11:165
  6. The epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) play pivotal roles in metastasis of epithelial cancers. The distinction between them has shed new light on the mole...

    Authors: Songming Ding, Wu Zhang, Zhiyuan Xu, Chunyang Xing, Haiyang Xie, Haijun Guo, Kanjie Chen, Penghong Song, Yu Gu, Fengqiang Xiao, Lin Zhou and Shusen Zheng
    Citation: Journal of Translational Medicine 2013 11:164
  7. Hearing loss is caused by several environmental and genetic factors and the proportion attributed to inherited causes is assumed at 50 ~ 60% . Mutations in GJB2 and mitochondrial DNA (mtDNA) 12S rRNA are the most...

    Authors: Qinjun Wei, Shuai Wang, Jun Yao, Yajie Lu, Zhibin Chen, Guangqian Xing and Xin Cao
    Citation: Journal of Translational Medicine 2013 11:163
  8. The aim of the present study was to investigate within ovarian carcinoma and normal ovarian biopsies the gene expression of multiple secretoglobin family members relative to mammaglobin B, which we previously ...

    Authors: Eliana Bignotti, Renata A Tassi, Stefano Calza, Antonella Ravaggi, Elisa Rossi, Carla Donzelli, Paola Todeschini, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Mario Carnazza, Francesco Quadraro, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Dana M Roque…
    Citation: Journal of Translational Medicine 2013 11:162
  9. Penile cancer (PC) is a rare tumor, and therapeutic options are limited for this disease, with an overall 5-year overall survival around 65-70%. Adjuvant therapy is not recommended for patients with N0-1 disea...

    Authors: Giuseppe Di Lorenzo, Sisto Perdonà, Carlo Buonerba, Guru Sonpavde, Vincenzo Gigantino, Giuseppe Pannone, Giuseppe Quarto, Matteo Ferro, Gabriella Gaudioso, Daniela Terracciano, Rossella Di Trolio, Pasquale Rescigno, Gerardo Botti, Sabino De Placido, Gaetano Facchini, Paolo A Ascierto…
    Citation: Journal of Translational Medicine 2013 11:161
  10. Patients with B cell malignancies refractory to allogeneic stem cell transplantation (SCT) can be treated by subsequent immunotherapy with donor lymphocyte infusions (DLI). But unlike myeloid leukemia, B cell ...

    Authors: Raymund Buhmann, Stanglmaier Michael, Hess Juergen, Lindhofer Horst, Christian Peschel and Hans-Jochem Kolb
    Citation: Journal of Translational Medicine 2013 11:160
  11. The Respiratory Quotient is a parameter reflecting the utilization of the nutrients by a subject. It is associated with an high rate of subsequent weight gain and with the atherosclerosis. Subjects tending to ...

    Authors: Yvelise Ferro, Carmine Gazzaruso, Adriana Coppola, Stefano Romeo, Valeria Migliaccio, Andrea Giustina, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2013 11:159
  12. A successful therapeutic strategy, specifically tailored to the molecular constitution of an individual and their disease, is an ambitious objective of modern medicine. In this report, we highlight a feasibili...

    Authors: Noel R Monks, David M Cherba, Steven G Kamerling, Heather Simpson, Anthony W Rusk, Derrick Carter, Emily Eugster, Marie Mooney, Robert Sigler, Matthew Steensma, Tessa Grabinski, Keith R Marotti and Craig P Webb
    Citation: Journal of Translational Medicine 2013 11:158
  13. 2-8% of all children aged between 6 months and 5 years have febrile seizures. Often these seizures cease spontaneously, however depending on different national guidelines, 20-40% of the patients would need the...

    Authors: Stephanie Ohlraun, Tobias Wollersheim, Claudia Weiß, Peter Martus, Steffen Weber-Carstens, Dietmar Schmitz and Markus Schuelke
    Citation: Journal of Translational Medicine 2013 11:157
  14. There is a significant clinical overlap between patients with hepatocyte nuclear factor (HNF)-1A and HNF4A maturity-onset diabetes of the young (MODY), two forms of monogenic diabetes. HNF1A and HNF4A are tran...

    Authors: Ma P Kyithar, Caroline Bonner, Siobhan Bacon, Seán M Kilbride, Jasmin Schmid, Rolf Graf, Jochen HM Prehn and Maria M Byrne
    Citation: Journal of Translational Medicine 2013 11:156
  15. Glioblastoma multiforme (GBM) is one of the most aggressive forms of cancer with a high rate of recurrence. We propose a novel oncolytic vaccinia virus (VACV)-based therapy using expression of the bone morphog...

    Authors: Rohit Duggal, Ulrike Geissinger, Qian Zhang, Jason Aguilar, Nanhai G Chen, Elena Binda, Angelo L Vescovi and Aladar A Szalay
    Citation: Journal of Translational Medicine 2013 11:155
  16. MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still u...

    Authors: Han Qin, Guang-xian Chen, Meng-ya Liang, Jian Rong, Jian-ping Yao, Hai Liu and Zhong-kai Wu
    Citation: Journal of Translational Medicine 2013 11:154
  17. Given the complexity of tumor microenvironment, no single marker from cancer cells could adequately predict the clinical outcomes of gastric cancer (GC). The objective of this study was to evaluate the prognos...

    Authors: Chun-Wei Peng, Lin-Wei Wang, Min Fang, Gui-Fang Yang, Yan Li and Dai-Wen Pang
    Citation: Journal of Translational Medicine 2013 11:153
  18. New treatment modalities are needed for the treatment of cancers of the head and neck region (HNSCC). Survivin is important for the survival and proliferation of tumor cells and may therefore provide a target ...

    Authors: Annelies W Turksma, Hetty J Bontkes, Janneke J Ruizendaal, Kirsten BJ Scholten, Johanneke Akershoek, Shakila Rampersad, Laura M Moesbergen, Saskia AGM Cillessen, Saskia JAM Santegoets, Tanja D de Gruijl, C René Leemans, Chris JLM Meijer and Erik Hooijberg
    Citation: Journal of Translational Medicine 2013 11:152
  19. Colorectal cancer (CRC) remains one of the most common cancers worldwide. We observed that MUC20 was significantly up-regulated in CRC patients with poor prognosis based on the microarray analysis. However, li...

    Authors: Xiuying Xiao, Lisha Wang, Ping Wei, Yayun Chi, Dali Li, Qifeng Wang, Shujuan Ni, Cong Tan, Weiqi Sheng, Menghong Sun, Xiaoyan Zhou and Xiang Du
    Citation: Journal of Translational Medicine 2013 11:151
  20. Acute myeloid leukemia (AML) and other aggressive refractory hematological malignancies unresponsive to upfront therapy remain difficult conditions to treat. Often, the focus of therapy is centered on achievin...

    Authors: John L Reagan, Loren D Fast, Howard Safran, Martha Nevola, Eric S Winer, Jorge J Castillo, James N Butera, Matthew I Quesenberry, Carolyn T Young and Peter J Quesenberry
    Citation: Journal of Translational Medicine 2013 11:150
  21. Ovarian cancer, like most solid tumors, is in dire need of effective therapies. The significance of this trial lies in its promise to spearhead the development of combination immunotherapy and to introduce nov...

    Authors: Lana E Kandalaft, Cheryl L Chiang, Janos Tanyi, Greg Motz, Klara Balint, Rosemarie Mick and George Coukos
    Citation: Journal of Translational Medicine 2013 11:149
  22. A promising cancer vaccine involves the fusion of tumor cells with dendritic cells (DCs). As such, a broad spectrum of both known and unidentified tumor antigens is presented to the immune system in the contex...

    Authors: Chunrui Tan, Varun Reddy, Jens Dannull, Enyu Ding, Smita K Nair, Douglas S Tyler, Scott K Pruitt and Walter T Lee
    Citation: Journal of Translational Medicine 2013 11:148
  23. Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic know...

    Authors: Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros and Florian Cabillic
    Citation: Journal of Translational Medicine 2013 11:147
  24. Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.

    Authors: Maria Libera Ascierto, Michael O Idowu, Yingdong Zhao, Hanif Khalak, Kyle K Payne, Xiang-Yang Wang, Catherine I Dumur, Davide Bedognetti, Sara Tomei, Paolo A Ascierto, Anil Shanker, Harry D Bear, Ena Wang, Francesco M Marincola, Andrea De Maria and Masoud H Manjili
    Citation: Journal of Translational Medicine 2013 11:145
  25. Peripheral vascular disease of the lower extremities comprises a clinical spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI). Bone marrow derived Mesenchymal Stem Cells (B...

    Authors: Pawan K Gupta, Anoop Chullikana, Rajiv Parakh, Sanjay Desai, Anjan Das, Sanjay Gottipamula, Sagar Krishnamurthy, Naveen Anthony, Arun Pherwani and Anish S Majumdar
    Citation: Journal of Translational Medicine 2013 11:143
  26. The cell division cycle 20 homolog (CDC20) is an essential cofactor of the anaphase-promoting complex (APC/C). CDC20 overexpression has been detected in many types of human cancers; however, its clinical role ...

    Authors: Wen-jing Wu, Kai-shun Hu, De-shen Wang, Zhao-lei Zeng, Dong-sheng Zhang, Dong-liang Chen, Long Bai and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:142
  27. The α2-adrenoreceptor agonist dexmedetomidine is known to provide renoprotection against ischemia and reperfusion (I/R) injury. However the underlying molecular mechanisms remain unclear. The purpose of this stud...

    Authors: Yanna Si, Hongguang Bao, Liu Han, Hongwei Shi, Yuan Zhang, Li Xu, Chenhui Liu, Jinsong Wang, Xiaobing Yang, Akbar Vohra and Daqing Ma
    Citation: Journal of Translational Medicine 2013 11:141
  28. The aim of this study was to analyze the expression of protein tyrosine kinase 6 (PTK6) in nasopharyngeal carcinoma (NPC) samples, and to identify whether PTK6 can serve as a biomarker for the diagnosis and pr...

    Authors: Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong and Bo-hang Zeng
    Citation: Journal of Translational Medicine 2013 11:140
  29. While PDE5 inhibitors have revolutionized treatment of ED, approximately 30% of patients are non-responsive. A significant cause of this is vascular and smooth muscle dysfunction, as well as nerve atrophy. Aut...

    Authors: Thomas E Ichim, Timothy Warbington, Octav Cristea, Joseph L Chin and Amit N Patel
    Citation: Journal of Translational Medicine 2013 11:139
  30. Modified cell-based angiogenic therapy has become a promising novel strategy for ischemic heart and limb diseases. Most studies focused on myoblast, endothelial cell progenitors or bone marrow mesenchymal stro...

    Authors: Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Yu Sysoeva, Vsevolod A Tkachuk and Yelena V Parfyonova
    Citation: Journal of Translational Medicine 2013 11:138
  31. Recent insights into the genetic and somatic aberrations have initiated a new era of rapidly evolving targeted and immune-based treatments for melanoma. After decades of unsuccessful attempts to finding a more...

    Authors: Paolo A Ascierto, Antonio M Grimaldi, Nicolas Acquavella, Lorenzo Borgognoni, Luana Calabrò, Natale Cascinelli, Alessandra Cesano, Michele Del Vecchio, Alexander M Eggermont, Mark Faries, Soldano Ferrone, Bernard A Fox, Thomas F Gajewski, Jérôme Galon, Sacha Gnjatic, Helen Gogas…
    Citation: Journal of Translational Medicine 2013 11:137
  32. In an attempt to engineer a regulatory compliant form of cell assisted lipotransfer in the U.S., the authors developed Autologous Fat Transfer with In-situ Mediation (AIM) for reconstruction of a refractory surgi...

    Authors: Allan Y Wu and David M Morrow
    Citation: Journal of Translational Medicine 2013 11:136

    The Erratum to this article has been published in Journal of Translational Medicine 2014 12:269

  33. In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a ...

    Authors: Laura Ridolfi, Massimiliano Petrini, Anna Maria Granato, Giusy Gentilcore, Ester Simeone, Paolo Antonio Ascierto, Elena Pancisi, Valentina Ancarani, Laura Fiammenghi, Massimo Guidoboni, Francesco de Rosa, Linda Valmorri, Emanuela Scarpi, Stefania Vittoria Luisa Nicoletti, Stefano Baravelli, Angela Riccobon…
    Citation: Journal of Translational Medicine 2013 11:135
  34. Diabetic nephropathy (DN) is the most common cause of end-stage renal failure. Although angiotensin II receptor blockers (ARBs) can be used to attenuate proteinuria in DN patients, their efficacy remains limit...

    Authors: Yongchun Ge, Honglang Xie, Shijun Li, Bo Jin, Jinhua Hou, Haitao Zhang, Mingjun Shi and Zhihong Liu
    Citation: Journal of Translational Medicine 2013 11:134
  35. Polycystic ovarian syndrome (PCOS) is one of the most common reproductive disorders with strong association with both insulin resistance and non-alcoholic fatty liver disease (NAFLD). To untangle the complex r...

    Authors: Ancha Baranova, Thuy Phuong Tran, Arian Afendy, Lei Wang, Amirhossein Shamsaddini, Rohini Mehta, Vikas Chandhoke, Aybike Birerdinc and Zobair M Younossi
    Citation: Journal of Translational Medicine 2013 11:133
  36. Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We previously reported that over-expression of an inhibitor of DNA binding/differentiation 1 (Id1) in EPCs can enhance EPC proli...

    Authors: Yajuan Su, Lingjuan Gao, Lichen Teng, Ying Wang, Jialin Cui, Shiyun Peng and Songbin Fu
    Citation: Journal of Translational Medicine 2013 11:132
  37. Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study ...

    Authors: Jennifer S Tront, Alliric Willis, Yajue Huang, Barbara Hoffman and Dan A Liebermann
    Citation: Journal of Translational Medicine 2013 11:131
  38. The present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diag...

    Authors: Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee and Manika Pal Bhadra
    Citation: Journal of Translational Medicine 2013 11:130
  39. Deceased after cardiac arrest donor are an additional source of kidney graft to overcome graft shortage. Deciphering the respective role of renal warm and cold ischemia is of pivotal interest in the transplant...

    Authors: Ludivine Rossard, Frédéric Favreau, Sebastien Giraud, Raphael Thuillier, Sylvain Le Pape, Jean Michel Goujon, Alexandre Valagier and Thierry Hauet
    Citation: Journal of Translational Medicine 2013 11:129
  40. Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging due to its implications for the design of protocols suitable for clinical applications, which means not only using safe products, b...

    Authors: Paulina García-González, Rodrigo Morales, Lorena Hoyos, Jaxaira Maggi, Javier Campos, Bárbara Pesce, David Gárate, Milton Larrondo, Rodrigo González, Lilian Soto, Verónica Ramos, Pía Tobar, María Carmen Molina, Karina Pino-Lagos, Diego Catalán and Juan Carlos Aguillón
    Citation: Journal of Translational Medicine 2013 11:128
  41. Virus-like particles (VLPs) from an Italian GII.4 norovirus strain were used to investigate activation and maturation of circulating antigen presenting cells (APCs) of human origin.

    Authors: Eleonora Ponterio, Annacarmen Petrizzo, Ilaria Di Bartolo, Franco Maria Buonaguro, Luigi Buonaguro and Franco Maria Ruggeri
    Citation: Journal of Translational Medicine 2013 11:127
  42. When patients with ocular motor deficits come to the clinic, in numerous situations it is hard to relate their behavior to one or several deficient neural structures. We sought to demonstrate that neuromimetic...

    Authors: Pierre M Daye, Lance M Optican, Emmanuel Roze, Bertrand Gaymard and Pierre Pouget
    Citation: Journal of Translational Medicine 2013 11:125
  43. Mild therapeutic hypothermia (HT) has been implemented in the management of post cardiac arrest (CA) syndrome after the publication of clinical trials comparing HT with common practice (ie, usually hyperthermi...

    Authors: Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Svatava Horakova, Marcela Skabradova, Frantisek Holy, Tomas Svoboda, Jan Belohlavek, Vladimir Hrachovina, Ludek Taborsky, Vlasta Dudkova, Hana Psotova, Otomar Kittnar and Petr Neuzil
    Citation: Journal of Translational Medicine 2013 11:124
  44. Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the developm...

    Authors: Tvrtko Hudolin, Zeljko Kastelan, Ivana Ilic, Katarina Levarda-Hudolin, Nikolina Basic-Jukic, Malte Rieken, Giulio C Spagnoli, Antonio Juretic and Chantal Mengus
    Citation: Journal of Translational Medicine 2013 11:123
  45. The long non-coding RNAs (lncRNAs) study has gradually become one of the hot topics in the field of RNA biology. One lncRNA which has attracted attention is LOC285194, a lncRNA demonstrated the potential tumor...

    Authors: Peng Qi, Mi-die Xu, Shu-juan Ni, Dan Huang, Ping Wei, Cong Tan, Xiao-yan Zhou and Xiang Du
    Citation: Journal of Translational Medicine 2013 11:122
  46. Large databases focused on genetic susceptibility to prostate cancer have been accumulated from population studies of different ancestries, including Europeans and African-Americans. Arab populations, however,...

    Authors: Jingxuan Shan, Khalid Al-Rumaihi, Danny Rabah, Issam Al-Bozom, Dhanya Kizhakayil, Karim Farhat, Sami Al-Said, Hala Kfoury, Shoba P Dsouza, Jillian Rowe, Hanif G Khalak, Shahzad Jafri, Idil I Aigha and Lotfi Chouchane
    Citation: Journal of Translational Medicine 2013 11:121
  47. Cancer vaccines are considered a promising therapeutic approach. However, their clinical results are not yet satisfactory. This may be due to the the difficulty of selection of an efficient tumor associated an...

    Authors: Francesca Kalli, Rodolfo Machiorlatti, Florinda Battaglia, Alessia Parodi, Giuseppina Conteduca, Francesca Ferrera, Michele Proietti, Samuele Tardito, Marina Sanguineti, Enrico Millo, Daniela Fenoglio, Raffaele De Palma, Giorgio Inghirami and Gilberto Filaci
    Citation: Journal of Translational Medicine 2013 11:120

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