Breast cancer is one of the most frequent malignancies and the second leading cause of cancer-related mortality in women. MicroRNAs play a key role in breast cancer development and progression. microRNA(miR)-8...
Authors: Yujing Gao, Hongning Ma, Chanchan Gao, Ye Lv, XueHua Chen, Rongrong Xu, Miao Sun, Xinrui Liu, Xiaohong Lu, Xiuying Pei and Pu Li
Citation:Journal of Translational Medicine
2018
16:38
Content type: ResearchPublished on: 23 February 2018
An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated t...
Authors: Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park and Mi-La Cho
Citation:Journal of Translational Medicine
2018
16:37
Content type: ResearchPublished on: 21 February 2018
Bronchopulmonary dysplasia (BPD) is the result of a complex process in which several prenatal and/or postnatal factors interfere with lower respiratory tract development, leading to a severe, lifelong disease....
Authors: Nicola Principi, Giada Maria Di Pietro and Susanna Esposito
Citation:Journal of Translational Medicine
2018
16:36
Content type: ReviewPublished on: 20 February 2018
Cross-sectional investigations report shorter telomeres in patients with heart failure (HF); however, no studies describe telomere length (TL) trajectory and its relationship with HF progression. Here we aimed...
Authors: Iris Teubel, Elena Elchinova, Santiago Roura, Marco A. Fernández, Carolina Gálvez-Montón, Pedro Moliner, Marta de Antonio, Josep Lupón and Antoni Bayés-Genís
Citation:Journal of Translational Medicine
2018
16:35
Content type: ResearchPublished on: 20 February 2018
Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skelet...
Authors: Ákos Tényi, Isaac Cano, Francesco Marabita, Narsis Kiani, Susana G. Kalko, Esther Barreiro, Pedro de Atauri, Marta Cascante, David Gomez-Cabrero and Josep Roca
Citation:Journal of Translational Medicine
2018
16:34
Content type: ResearchPublished on: 20 February 2018
In the original version of this article [1], published on 7 November 2017, affiliation 18 has been incorrectly assigned to the authors Serena Magi and Laura Mazzoni. They are only affiliated to the Skin Cancer...
Authors: Maria A. Pizzichetta, Daniela Massi, Mario Mandalà, Paola Queirolo, Ignazio Stanganelli, Vincenzo De Giorgi, Giovanni Ghigliotti, Stefano Cavicchini, Pietro Quaglino, Maria T. Corradin, Pietro Rubegni, Mauro Alaibac, Stefano Astorino, Fabrizio Ayala, Serena Magi, Laura Mazzoni…
Citation:Journal of Translational Medicine
2018
16:33
Content type: CorrectionPublished on: 20 February 2018
The
original article was published in Journal of Translational Medicine
2017
15:227
Pathological scarring in wounds is a prevalent clinical outcome with limited prognostic options. The objective of this study was to investigate whether cellular signaling proteins could be used as prognostic b...
Authors: Sridevi Nagaraja, Lin Chen, Luisa A. DiPietro, Jaques Reifman and Alexander Y. Mitrophanov
Citation:Journal of Translational Medicine
2018
16:32
Content type: ResearchPublished on: 20 February 2018
Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent short-term...
Authors: Urvashi Kaundal, Upma Bagai and Aruna Rakha
Citation:Journal of Translational Medicine
2018
16:31
Content type: ReviewPublished on: 15 February 2018
The presence of B cells in early stage non-small cell lung cancer (NSCLC) is associated with longer survival, however, the role these cells play in the generation and maintenance of anti-tumor immunity is uncl...
Authors: Sara M. Centuori, Cecil J. Gomes, Samuel S. Kim, Charles W. Putnam, Brandon T. Larsen, Linda L. Garland, David W. Mount and Jesse D. Martinez
Citation:Journal of Translational Medicine
2018
16:30
Content type: ResearchPublished on: 15 February 2018
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE)...
Authors: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang and Chunmao Han
Citation:Journal of Translational Medicine
2018
16:29
Content type: ReviewPublished on: 15 February 2018
While the promise of the Human Genome Project provided significant insights into the structure of the human genome, the complexities of disease at the individual level have made it difficult to utilize –omic i...
Authors: Patrick J. Silva, Valerie M. Schaibley and Kenneth S. Ramos
Citation:Journal of Translational Medicine
2018
16:28
Content type: ReviewPublished on: 15 February 2018
Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of...
Authors: Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody and Emilio Sacristán
Citation:Journal of Translational Medicine
2018
16:27
Content type: ResearchPublished on: 15 February 2018
During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen re...
Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter and Manfred Lehner
Citation:Journal of Translational Medicine
2018
16:26
Content type: ResearchPublished on: 8 February 2018
Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest that there are two sources of hepcidin in the brain; one is local and the other comes from the circulation. Little is k...
Authors: Driton Vela
Citation:Journal of Translational Medicine
2018
16:25
Preliminary evidence suggests that the enteric microbiota may play a role in the expression of neurological symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Overlapping symptoms with th...
Authors: Amy Wallis, Michelle Ball, Henry Butt, Donald P. Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa-Kwee and Dorothy Bruck
Citation:Journal of Translational Medicine
2018
16:24
Content type: ResearchPublished on: 6 February 2018
Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vac...
Authors: Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup and Karin Schilbach
Citation:Journal of Translational Medicine
2018
16:23
Content type: ResearchPublished on: 6 February 2018
An extensive crosstalk co-regulates the Hippo and Wnt pathway. Preclinical studies revealed that the Hippo transducers YAP/TAZ mediate a number of oncogenic functions in gastric cancer (GC). Moreover, comprehe...
Authors: Elisa Melucci, Beatrice Casini, Livia Ronchetti, Laura Pizzuti, Francesca Sperati, Matteo Pallocca, Francesca De Nicola, Frauke Goeman, Enzo Gallo, Carla Azzurra Amoreo, Domenico Sergi, Irene Terrenato, Patrizia Vici, Luigi Di Lauro, Maria Grazia Diodoro, Edoardo Pescarmona…
Citation:Journal of Translational Medicine
2018
16:22
Content type: ResearchPublished on: 5 February 2018
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients wi...
Authors: Peter C. Rowe, Colleen L. Marden, Scott Heinlein and Charles C. Edwards II
Citation:Journal of Translational Medicine
2018
16:21
Content type: ResearchPublished on: 2 February 2018
Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have bee...
Authors: Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M. Ali, Monira Al-Arouj, Abdullah Bennakhi, Osama Alsmadi and Naser Elkum
Citation:Journal of Translational Medicine
2018
16:20
Content type: ResearchPublished on: 30 January 2018
Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor i...
Authors: Weitao Zhang, Jiawei Li, Guisheng Qi, Guowei Tu, Cheng Yang and Ming Xu
Citation:Journal of Translational Medicine
2018
16:19
There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architec...
Authors: Claudio Carini, Ewan Hunter, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes and Carl S. Goodyear
Citation:Journal of Translational Medicine
2018
16:18
Content type: ResearchPublished on: 29 January 2018
Dipstick test is widely used to support the diagnosis of urinary tract infections (UTI). It is effective in ruling out UTI, but urine culture is needed for diagnosis confirmation. In this study we compared the...
Authors: Diana Lelli, Claudio Pedone, Pamela Alemanno, Alessandra Bertini, Claudia Di Gioia, Sara Fazzina, Giorgio Pennazza, Marco Santonico, Simone Grasso, Alessandro Zompanti, Silvia Angeletti and Raffaele Antonelli Incalzi
Citation:Journal of Translational Medicine
2018
16:17
Content type: ResearchPublished on: 25 January 2018
In most research projects budget, staff and IT infrastructures are limiting resources. Especially for small-scale registries and cohort studies professional IT support and commercial electronic data capture sy...
Authors: Martin Bialke, Henriette Rau, Oliver C. Thamm, Ronny Schuldt, Peter Penndorf, Arne Blumentritt, Robert Gött, Jens Piegsa, Thomas Bahls and Wolfgang Hoffmann
Citation:Journal of Translational Medicine
2018
16:16
Content type: MethodologyPublished on: 25 January 2018
Squamous cell carcinoma is the dominant type of esophageal cancer in China with many patients initially diagnosed at advanced stage. Patient-derived xenografts (PDX) models have been developed to be an importa...
Authors: Jianling Zou, Ying Liu, Jingyuan Wang, Zhentao Liu, Zhihao Lu, Zuhua Chen, Zhongwu Li, Bin Dong, Wenwen Huang, Yanyan Li, Jing Gao and Lin Shen
Citation:Journal of Translational Medicine
2018
16:15
Content type: ResearchPublished on: 25 January 2018
Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. I...
Authors: Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti and Bharat B. Aggarwal
Citation:Journal of Translational Medicine
2018
16:14
Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewha...
Authors: Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek and Steven L. Highfill
Citation:Journal of Translational Medicine
2018
16:13
Content type: ResearchPublished on: 24 January 2018
To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery.
Authors: Lu-Lu Ye, Ronald Wihal Oei, Fang-Fang Kong, Cheng-Run Du, Rui-Ping Zhai, Qing-Hai Ji, Chao-Su Hu and Hong-Mei Ying
Citation:Journal of Translational Medicine
2018
16:12
Content type: ResearchPublished on: 24 January 2018
Dental caries is a major worldwide oral disease afflicting a large proportion of children. As an important host factor of caries susceptibility, saliva plays a significant role in the occurrence and developmen...
Authors: Kun Wang, Yufei Wang, Xiuqing Wang, Qian Ren, Sili Han, Longjiang Ding, Zhongcheng Li, Xuedong Zhou, Wei Li and Linglin Zhang
Citation:Journal of Translational Medicine
2018
16:11
Content type: ResearchPublished on: 19 January 2018
Numerous studies have investigated the role of the monounsaturated fatty acid and other dietary factors in the prevention of cognitive decline but the short-term effect of a low dose of extravirgin olive oil o...
Bladder cancer (BCa) is one of the most common cancers in the urinary system among the world. Previous studies suggested that TMEM40 expression level was significantly associated with clinicopathological param...
Authors: Zhen-Fei Zhang, Han-Rong Zhang, Qing-Yan Zhang, Shu-Yu Lai, Yu-Zhen Feng, Yi Zhou, Si-Rong Zheng, Rong Shi and Jue-Yu Zhou
Citation:Journal of Translational Medicine
2018
16:9
Content type: ResearchPublished on: 19 January 2018
The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic–pituitary–adrenal (HPA) axis and sympatheti...
Authors: Ryungsa Kim
Citation:Journal of Translational Medicine
2018
16:8
Esophageal carcinoma is the eighth prevalent malignancy and ranks the sixth in carcinoma-related death worldwide. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) has been identified as a tumor suppres...
Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas ...
Authors: Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro and Fernando Civeira
Citation:Journal of Translational Medicine
2018
16:6
Content type: ResearchPublished on: 15 January 2018
Authors: David Carbone, Michael Sharpnack, Kai He, Lisa H. Butterfield, Alexander M. M. Eggermont, Maria Gonzalez-Cao, Niki Karachaliou, Guillermo Crespo, Erika Aldeguer, Ana Drozdowskyj, Ana Giménez-Capitán, Cristina Teixidó, Miguel Angel Molina-Vila, Santiago Viteri Ramírez, Salvador Martin Algarra, Elisabeth Pérez-Ruiz…
Citation:Journal of Translational Medicine
2018
16(Suppl 1):4
Content type: Meeting abstractsPublished on: 15 January 2018
To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentap...
Authors: Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland and Ajay Goel
Citation:Journal of Translational Medicine
2018
16:5
Content type: ResearchPublished on: 12 January 2018
γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune syst...
Authors: Yijing Zhao, Chao Niu and Jiuwei Cui
Citation:Journal of Translational Medicine
2018
16:3
HIF1α, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is required to prevent development of maternal–...
Authors: Karen Vrijens, Maria Tsamou, Narjes Madhloum, Wilfried Gyselaers and Tim S. Nawrot
Citation:Journal of Translational Medicine
2018
16:2
Content type: ResearchPublished on: 10 January 2018
Plasma extracellular vesicles (EVs), especially exosome-like vesicles (ELVs), are being increasingly explored as a source of potential noninvasive disease biomarkers. The discovery of blood-based biomarkers as...
Authors: Ruzena Stranska, Laurens Gysbrechts, Jens Wouters, Pieter Vermeersch, Katarzyna Bloch, Daan Dierickx, Graciela Andrei and Robert Snoeck
Citation:Journal of Translational Medicine
2018
16:1
Content type: ResearchPublished on: 9 January 2018
Breast cancer brain metastases (BCBM) develop in about 20–30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of valuable molecular therapeutic targets. The a...
Authors: Hans-Juergen Schulten, Mohammed Bangash, Sajjad Karim, Ashraf Dallol, Deema Hussein, Adnan Merdad, Fatma K. Al-Thoubaity, Jaudah Al-Maghrabi, Awatif Jamal, Fahad Al-Ghamdi, Hani Choudhry, Saleh S. Baeesa, Adeel G. Chaudhary and Mohammed H. Al-Qahtani
Citation:Journal of Translational Medicine
2017
15:269
Content type: ResearchPublished on: 29 December 2017
In our previous study, we revealed that MEG3 was a tumor suppressor gene in retinoblastoma and inhibited proliferation of retinoblastoma cells by regulating the activity of the Wnt/β-catenin pathway. Here, we ...
Authors: Yali Gao, Peng Huang and Jun Zhang
Citation:Journal of Translational Medicine
2017
15:268
Content type: ResearchPublished on: 29 December 2017
Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...
Authors: Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar
Citation:Journal of Translational Medicine
2017
15:266
Content type: ResearchPublished on: 28 December 2017
Ulcerative colitis (UC) is a highly progressive inflammatory disease that requires the interaction of epithelial, immune, endothelial and muscle cells and fibroblasts. Previous studies suggested two inflammato...
Authors: Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck and Roswitha Gropp
Citation:Journal of Translational Medicine
2017
15:265
Content type: ResearchPublished on: 28 December 2017
Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of a proven platform that maintains an identical ...
Authors: Jörg Felder, A. Avdo Celik, Chang-Hoon Choi, Stefan Schwan and N. Jon Shah
Citation:Journal of Translational Medicine
2017
15:264
Content type: MethodologyPublished on: 28 December 2017
Alveolar cleft repair is performed via bone grafting procedure to restore the dental arch continuity. A suitable bone substitute materials should possess osteoinductive and osteoconductive properties, to promo...
Authors: Mohammad Kamal, Lars Andersson, Rene Tolba, Adel Al-Asfour, Alexander K. Bartella, Felix Gremse, Stefanie Rosenhain, Frank Hölzle, Peter Kessler and Bernd Lethaus
Citation:Journal of Translational Medicine
2017
15:263
Content type: ResearchPublished on: 23 December 2017
Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath condensate (EBC) is a relatively unexplored matrix which reflects the signat...
Authors: Anirban Sinha, Koundinya Desiraju, Kunal Aggarwal, Rintu Kutum, Siddhartha Roy, Rakesh Lodha, S. K. Kabra, Balaram Ghosh, Tavpritesh Sethi and Anurag Agrawal
Citation:Journal of Translational Medicine
2017
15:262
Content type: ResearchPublished on: 22 December 2017
The problem of drug resistance and bacterial persistence in tuberculosis is a cause of global alarm. Although, the UN’s Sustainable Development Goals for 2030 has targeted a Tb free world, the treatment gap ex...
Authors: Divneet Kaur, Shalu Mathew, Chinchu G. S. Nair, Azitha Begum, Ashwin K. Jainanarayan, Mukta Sharma and Samir K. Brahmachari
Citation:Journal of Translational Medicine
2017
15:261
Content type: ResearchPublished on: 21 December 2017
Prostate cancer (PCa) is a complex disorder resulting from the combined effects of multiple environmental and genetic factors. Small non-coding RNAs (sRNAs), particularly microRNAs (miRNAs), regulate several c...
Authors: Jingxuan Shan, Khalid Al-Rumaihi, Karim Chouchane, Issam Al-Bozom, Danny Rabah, Karim Farhat and Lotfi Chouchane
Citation:Journal of Translational Medicine
2017
15:260
Content type: ResearchPublished on: 21 December 2017
NRTIs-sparing regimens exert favourable profiles on T-cell homeostasis associated parameters. Our aim was to analyze the effect of NRTIs sparing regimen (NRTI-sparing-cART) vs NRTIs-containing regimen (NRTI-cA...
Authors: A. Gonzalez-Serna, S. Ferrando-Martinez, L. Tarancon-Diez, R. S. De Pablo-Bernal, B. Dominguez-Molina, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Leal and E. Ruiz-Mateos
Citation:Journal of Translational Medicine
2017
15:259
Content type: ResearchPublished on: 20 December 2017
Metastasis is a major threat to colorectal cancer (CRC) patients. We have reported that peroxiredoxin-2 (PRDX2) is associated with CRC invasion and metastasis. However, the mechanisms regulating PRDX2 expressi...
Authors: Zhenbing Lv, Jinlai Wei, Wenxian You, Rong Wang, Jingkun Shang, Yongfu Xiong, Hua Yang, Xuanhua Yang and Zhongxue Fu
Citation:Journal of Translational Medicine
2017
15:257
Content type: ResearchPublished on: 19 December 2017