- Poster presentation
- Open Access
Interstitial lung disease in patients with scleroderma - Treatment with rituximab
Journal of Translational Medicine volume 8, Article number: P45 (2010)
Interstitial Lung Disease (ILD) is a severe complication of systemic sclerosis, more common among patients with diffuse scleroderma. Cyclophosphamide (CYC) is the treatment normally used in those patients, with irregular response. We have successfully treated 3 patients refractory to CYC with Rituximab (RTX).
Patients and methods
- Patient 1: A 43 years-old woman developed progressive cough and dyspnea, with radiological changes of interstitial lung disease. She began treatment with oral glucocorticoids and monthly boluses of CYC (1g i.v).
- Patient 2: A 53 years-old woman with a diagnosis of diffuse scleroderma three years earlier, started with dyspnea during low strain at the beginning. ILD was diagnosed with characteristic ground glass pattern on thoracic CT. She was given 6 boluses of CYC and oral glucocorticoids
- Patient 3: A 48 years-old women, with skin lesions suggestive of dermatomyositis (DM). In 2007 she was diagnosed of amyopathic DM with scleroderma overlap. Three 3 months after the diagnosis, she began with cough and dry expectoration, together with dyspnea. ILD was diagnosed with characteristic ground glass pattern on thoracic CT. She was initially treated monthly with CYC for 7 months. All patients, we started a treatment with RTX (2x1g) plus CYC.
Respiratory function tests showed improvements (See table 1).
Overexpression of B lymphocytes in Scleroderma pathogenesis, and the bad evolution of ILD in those patients aimed us to try RTX (anti CD-20) after CYC failure. We have observed clinical improvement with respiratory test (table 1) without progression in lung CT changes. Further studies would be necessary to establish this therapeutic approach.
Rights and permissions
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Muñoz, A., Martínez, R., Rodríguez, S. et al. Interstitial lung disease in patients with scleroderma - Treatment with rituximab. J Transl Med 8 (Suppl 1), P45 (2010). https://doi.org/10.1186/1479-5876-8-S1-P45
- Interstitial Lung Disease
- Systemic Sclerosis