- Poster presentation
- Open Access
BAFF polymorphisms and serum levels of BAFF in Tunisian systemic lupus erythematosus patients
Journal of Translational Medicine volume 10, Article number: P35 (2012)
To investigate any associations between regulatory genetic polymorphisms of BAFF gene, disease susceptibility and serum BAFF (s-BAFF) levels in Tunisian systemic lupus (SLE) patients.
The case-control study included 124 SLE patients and 152 healthy controls. Three single nucleotide polymorphisms (SNPs) (-2841 T>C, -2701 A>T and -871 C>T) in the 5’ regulatory region of the BAFF gene were explored by PCR-RFLP . s-BAFF levels were measured by ELISA (R&D Systems).
s-BAFF levels were elevated in SLE patients (1717,08 pg/ml) and in anti-dsDNA positive antibodies patients (1948,28 pg/ml) compared to both controls (665,82 pg/ml, p<10-3) and patients without anti-dsDNA antibodies (1281,51 pg/ml, p:0,007). In contrast, no correlation was found between global disease activity registered in SLEDAI and s-BAFF levels (p: 0.7). Furthermore, no association was found between BAFF genotypes and susceptibility to SLE. Single allele, genotype and haplotype association analyses showed no significant association with s-BAFF values, clinical features or SLEDAI score in SLE.
Polymorphisms in the regulatory region of the BAFF gene do contribute neither to increased s-BAFF levels nor to the susceptibility to SLE in Tunisian patients. Increased s-BAFF levels in anti-dsDNA positive antibodies SLE patients suggest the central role of this molecule in the inflammatory process involving in autoantibodies production.
Becker-Merok A, Nikolaisen C, Nossent HC: B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time. Lupus. 2006, 15: 570-6. 10.1177/0961203306071871.
Zhang J, Roscheke V, Baker KP: A role of B lymphocyte stimulator in systemic lupus erythematosus. J Immunol. 2001, 166: 6-10.
Eilertsen G, Van Ghelue M, Strand H, Nossent J: Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case-control study. Rheumatology. 2011, 50: 2197-2205. 10.1093/rheumatology/ker282.
Nossent JC, Lester S, Zahra D: Polymorphism in the 5’regulatory region of the B-lymphocyte activating factor gene is associated with the RO/La autoantibody response and serum BAFF levels in primary Sjogren’s syndrome. Rheumatology. 2008, 47: 1311-6. 10.1093/rheumatology/ken246.
Rights and permissions
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Laamiri, N., Sfar, I., Dhaouadi, T. et al. BAFF polymorphisms and serum levels of BAFF in Tunisian systemic lupus erythematosus patients. J Transl Med 10 (Suppl 3), P35 (2012). https://doi.org/10.1186/1479-5876-10-S3-P35
- Systemic Lupus Erythematosus
- Systemic Lupus Erythematosus Patient
- Regulatory Region
- Autoantibody Production
- Single Allele