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BAFF polymorphisms and serum levels of BAFF in Tunisian systemic lupus erythematosus patients
Journal of Translational Medicine volume 10, Article number: P35 (2012)
To investigate any associations between regulatory genetic polymorphisms of BAFF gene, disease susceptibility and serum BAFF (s-BAFF) levels in Tunisian systemic lupus (SLE) patients.
The case-control study included 124 SLE patients and 152 healthy controls. Three single nucleotide polymorphisms (SNPs) (-2841 T>C, -2701 A>T and -871 C>T) in the 5’ regulatory region of the BAFF gene were explored by PCR-RFLP . s-BAFF levels were measured by ELISA (R&D Systems).
s-BAFF levels were elevated in SLE patients (1717,08 pg/ml) and in anti-dsDNA positive antibodies patients (1948,28 pg/ml) compared to both controls (665,82 pg/ml, p<10-3) and patients without anti-dsDNA antibodies (1281,51 pg/ml, p:0,007). In contrast, no correlation was found between global disease activity registered in SLEDAI and s-BAFF levels (p: 0.7). Furthermore, no association was found between BAFF genotypes and susceptibility to SLE. Single allele, genotype and haplotype association analyses showed no significant association with s-BAFF values, clinical features or SLEDAI score in SLE.
Polymorphisms in the regulatory region of the BAFF gene do contribute neither to increased s-BAFF levels nor to the susceptibility to SLE in Tunisian patients. Increased s-BAFF levels in anti-dsDNA positive antibodies SLE patients suggest the central role of this molecule in the inflammatory process involving in autoantibodies production.
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Laamiri, N., Sfar, I., Dhaouadi, T. et al. BAFF polymorphisms and serum levels of BAFF in Tunisian systemic lupus erythematosus patients. J Transl Med 10, P35 (2012). https://doi.org/10.1186/1479-5876-10-S3-P35
- Systemic Lupus Erythematosus
- Systemic Lupus Erythematosus Patient
- Regulatory Region
- Autoantibody Production
- Single Allele