- Poster presentation
- Open Access
Dietary management of inflammatory diseases
Journal of Translational Medicine volume 10, Article number: P12 (2012)
Ulcerative colitis and Crohn’s disease are inflammatory diseases which are considered to be either associated with the genetic make-up of the individual or due to defective epithelial barrier. In the latter case, environment becomes favorable for proliferation of microorganisms  which then causes inflammation. The small intestine expresses gut-associated lymphoid tissue (GALT) to encounter pathogen  which (lymph nodes and payer’s patches etc.,) changes with changing in colonization of microbes . There are trillion of bacteria on the human gut and this microbiota population depends on nutritional status of the subjects. A healthy nutrition thus promote healthy microflora and vice versa. In some stressful condition (chemotherapy or poor nutrition) the balance in microbiota disturbed. This leads to invasive microbes to invade the gut and intestine. Intestinal cells possess conserve detecting system of bacterial antigens. This leads to progression and regulation of innate and adaptive immune responses. The GALT cells (macrophages, dendritic cells) sense signal from molecules, MHCI, II & TLRs . It would be imperative to characterize diet that promotes growth of microbes which expresses lipopolysaccharides, peptidoglycan etc., because microbes with the mentioned antigens causes inflammation.
Paul J, Verma AK, Verma R: Role of gut flora in inflammatory bowel disease- a state of art. Communicating Current Research and Educational Topics and Trends in Applied Microbiology. 2007, 705-718.
Hakansson A, Molin G: Gut microbiota and inflammation. Nutrients. 2011, 3: 637-682. 10.3390/nu3060637.
Forchielli ML, Walker WA: The role of gut-associated lymphoid tissues and mucosal defence. Br. J. Nutr. 2005, 93: S41-S48. 10.1079/BJN20041356.
Cario E, Brown D, McKee M, Lynch-Devaney K, Gerken G, Podolsk DK: Commensal associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am. J. Pathol. 2002, 160: 165-173. 10.1016/S0002-9440(10)64360-X.
Rights and permissions
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Bacha, U., Ali, M.A., Basit, A. et al. Dietary management of inflammatory diseases. J Transl Med 10 (Suppl 3), P12 (2012). https://doi.org/10.1186/1479-5876-10-S3-P12
- Ulcerative Colitis
- Inflammatory Disease
- Lymphoid Tissue
- Adaptive Immune Response