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  1. Content type: Research

    Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen

    Citation: Journal of Translational Medicine 2018 16:225

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  2. Content type: Research

    Circulating exosomes from prostate cancer (PCa) patients undergoing radiotherapy are attractive candidate biomarkers for monitoring treatment response. Multiple workflows for isolation and content characteriza...

    Authors: Bijaya Malla, Daniel M. Aebersold and Alan Dal Pra

    Citation: Journal of Translational Medicine 2018 16:223

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  3. Content type: Research

    Mesenchymal stem cells (MSCs) represent an attractive avenue for cellular therapies targeting degenerative diseases. MSC in vitro expansion is required in order to obtain therapeutic numbers during the manufac...

    Authors: C. Elabd, T. E. Ichim, K. Miller, A. Anneling, V. Grinstein, V. Vargas and F. J. Silva

    Citation: Journal of Translational Medicine 2018 16:222

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  4. Content type: Research

    Hepatitis B virus (HBV) infection is strongly associated with hepatocellular carcinoma due to the main pathogenic X protein of HBV (HBx). Whether HBV infection and the HBx protein could result in macular degen...

    Authors: Ruey-Hwang Chou, Chang-Yin Lee, Lee-Won Chong, Kuang-Hsi Chang, Cheng-Li Lin, Ke-Sin Yan, Chingfu Tsou and Yi-Chao Hsu

    Citation: Journal of Translational Medicine 2018 16:221

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  5. Content type: Research

    Circular RNAs (circRNAs) have received increasing attention in human tumor research. However, there are still a large number of unknown circRNAs that need to be deciphered. The aim of this study is to unearth ...

    Authors: Dan-dan Xiong, Yi-wu Dang, Peng Lin, Dong-yue Wen, Rong-quan He, Dian-zhong Luo, Zhen-bo Feng and Gang Chen

    Citation: Journal of Translational Medicine 2018 16:220

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  6. Content type: Research

    Immune checkpoint inhibitors have revolutionized the treatment paradigm of highly lethal malignancies like advanced non-small cell lung cancer (NSCLC), demonstrating long-term tumour control and extended patie...

    Authors: Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti and Paolo Marchetti

    Citation: Journal of Translational Medicine 2018 16:219

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  7. Content type: Research

    MicroRNAs play roles in the pathogenesis of bronchial asthma. However, the mechanism of miR-29c in allergic asthma remains unclear. This study is to elucidate the regulation of Th cell differentiation by miR-2...

    Authors: Xinxing Zhang, Xin Zhao, Huiming Sun, Yongdong Yan, Li Huang, Wenjin Gu, Wujun Jiang, Yuqing Wang, Canhong Zhu, Wei Ji, Chuangli Hao and Zhengrong Chen

    Citation: Journal of Translational Medicine 2018 16:218

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  8. Content type: Research

    Multiple myeloma (MM) is a cancer of terminally differentiated plasma that is part of a spectrum of blood diseases. The role of the micro-environment is crucial for MM clonal evolution.

    Authors: Angelina Boccarelli, Flavia Esposito, Mauro Coluccia, Maria Antonia Frassanito, Angelo Vacca and Nicoletta Del Buono

    Citation: Journal of Translational Medicine 2018 16:217

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  9. Content type: Research

    Little has been known about the role of non-coding RNA regulatory network in the patterns of growth and invasiveness of gastric cancer (GC) development.

    Authors: Jia Cheng, Huiqin Zhuo, Mao Xu, Linpei Wang, Hao Xu, Jigui Peng, Jingjing Hou, Lingyun Lin and Jianchun Cai

    Citation: Journal of Translational Medicine 2018 16:216

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  10. Content type: Research

    The globally rising obesity epidemic is associated with a broad spectrum of diseases including atherosclerosis and non-alcoholic fatty liver (NAFL) disease. In the past, research focused on the vasculature or ...

    Authors: Erik Taylor, Nasi Huang, Jacob Bodde, Andrew Ellison, Ronald Killiany, Markus Michael Bachschmid and James Hamilton

    Citation: Journal of Translational Medicine 2018 16:215

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  11. Content type: Research

    A relationship between rheumatoid arthritis (RA) and periodontitis has been suggested from findings that individuals with RA are prone to have advanced periodontitis and vice versa. In search of possible commo...

    Authors: Marianne Engström, Kaja Eriksson, Linkiat Lee, Monika Hermansson, Anders Johansson, Anthony P. Nicholas, Natalija Gerasimcik, Karin Lundberg, Lars Klareskog, Anca Irinel Catrina and Tülay Yucel-Lindberg

    Citation: Journal of Translational Medicine 2018 16:214

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  12. Content type: Commentary

    Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available...

    Authors: José María Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge María Núñez-Córdoba, Silvia López-Elío, Enrique Andreu, Fermín Sánchez-Guijo, José Dámaso Aquerreta, José María Bondía, Andrés Valentí-Azcárate, María del Consuelo del Cañizo, Eva María Villarón, Juan Ramón Valentí-Nin and Felipe Prósper

    Citation: Journal of Translational Medicine 2018 16:213

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  13. Content type: Review

    Mesenchymal stem cell (MSC) therapy offers great potential for treatment of disease through the multifunctional and responsive ability of these cells. In numerous contexts, MSC have been shown to reduce inflam...

    Authors: Thomas E. Ichim, Pete O’Heeron and Santosh Kesari

    Citation: Journal of Translational Medicine 2018 16:212

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  14. Content type: Commentary

    Although precision medicine has made advances in individualized patient treatments, there needs to be continued attention on tailored population health and prevention strategies (often termed “precision popula...

    Authors: Courtney R. Lyles, Mitchell R. Lunn, Juno Obedin-Maliver and Kirsten Bibbins-Domingo

    Citation: Journal of Translational Medicine 2018 16:211

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  15. Content type: Research

    Membranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adult patients. Despite extensive evidences suggested that many immune-related genes could serve as effective biomarkers in...

    Authors: Chengwei Zhang, Lei Leng, Xiaoming Zhang, Yao Zhao and Zhaozheng Li

    Citation: Journal of Translational Medicine 2018 16:210

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  16. Content type: Research

    Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...

    Authors: Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng

    Citation: Journal of Translational Medicine 2018 16:209

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  17. Content type: Research

    In this study, we develop reliable and practical virtual coiling and stenting methods for intracranial aneurysm surgical planning. Since the purpose of deploying coils and stents is to provide device geometrie...

    Authors: Xiaochang Leng, Yang Wang, Jing Xu, Yeqing Jiang, Xiaolong Zhang and Jianping Xiang

    Citation: Journal of Translational Medicine 2018 16:208

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  18. Content type: Meeting report

    Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape ...

    Authors: Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A. Davies, Reinhard Dummer, Soldano Ferrone, Thomas F. Gajewski, Claus Garbe, Jason J. Luke, Francesco M. Marincola, Giuseppe Masucci, Janice M. Mehnert…

    Citation: Journal of Translational Medicine 2018 16:207

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  19. Content type: Research

    The early and accurate diagnosis of tuberculosis (TB) is critical for controlling the global TB epidemic. Although early studies have supported the potential role of cytokine biomarkers in blood for the diagno...

    Authors: Sen Wang, Yang Li, Yaojie Shen, Jing Wu, Yan Gao, Shu Zhang, Lingyun Shao, Jialin Jin, Ying Zhang and Wenhong Zhang

    Citation: Journal of Translational Medicine 2018 16:206

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  20. Content type: Research

    The purpose of this study was to achieve early and accurate diagnosis of lung cancer and long-term monitoring of the therapeutic response.

    Authors: Zhirui Fan, Wenhua Xue, Lifeng Li, Chaoqi Zhang, Jingli Lu, Yunkai Zhai, Zhenhe Suo and Jie Zhao

    Citation: Journal of Translational Medicine 2018 16:205

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  21. Content type: Research

    A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent stud...

    Authors: Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, Anna Szpila, Kinga Linowiecka, Jolanta Guz, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski, Daniel Gackowski and Ryszard Olinski

    Citation: Journal of Translational Medicine 2018 16:204

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  22. Content type: Research

    Sperm selection is essential for the health of offspring conceived via assistive reproductive technology (ART). Various methods of sperm preparation for in vitro fertilization and intracytoplasmic sperm inject...

    Authors: Kun Li, Rui Li, Ya Ni, Peibei Sun, Ye Liu, Dan Zhang and Hefeng Huang

    Citation: Journal of Translational Medicine 2018 16:203

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  23. Content type: Research

    Acute renal allograft rejection is a common complication after renal transplantation that often leads to chronic rejection and ultimate graft loss. While renal allograft biopsy remains the gold standard for di...

    Authors: Long Zheng, Jina Wang, Wenjun Gao, Chao Hu, Shuo Wang, Ruiming Rong, Yinlong Guo, Tongyu Zhu and Dong Zhu

    Citation: Journal of Translational Medicine 2018 16:202

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  24. Content type: Research

    Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) thr...

    Authors: Qinrui Han, Ye Ma, Hao Wang, Yu Dai, Chunhui Chen, Yawei Liu, Linlin Jing and Xuegang Sun

    Citation: Journal of Translational Medicine 2018 16:201

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  25. Content type: Research

    Stored platelets undergo deleterious changes, referred to as platelet storage lesions (PSLs), which accelerate the desialylation of platelets and result in their phagocytosis and clearance by hepatic macrophag...

    Authors: Jooyoung Cho, Hyunkyung Kim, Jaewoo Song, June-Won Cheong, Jeong Won Shin, Woo Ick Yang and Hyun Ok Kim

    Citation: Journal of Translational Medicine 2018 16:199

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  26. Content type: Methodology

    Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which i...

    Authors: Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou and Wenrui Lu

    Citation: Journal of Translational Medicine 2018 16:198

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  27. Content type: Research

    UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response. UGT1A1 is a m...

    Authors: Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2018 16:197

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  28. Content type: Protocol

    Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. ...

    Authors: Daniel S. Green, Ana T. Nunes, Virginia David-Ocampo, Irene B. Ekwede, Nicole D. Houston, Steven L. Highfill, Hanh Khuu, David F. Stroncek, Seth M. Steinberg, Kathryn C. Zoon and Christina M. Annunziata

    Citation: Journal of Translational Medicine 2018 16:196

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  29. Content type: Research

    Currently, mismatch repair-deficient (dMMR) status is a promising candidate for targeted immune checkpoint inhibition therapy in colorectal cancer (CRC) patients, however, the potential immunological mechanism...

    Authors: Shou-Sheng Liu, Yuan-Zhong Yang, Chang Jiang, Qi Quan, Qian-Kun Xie, Xiao-Pai Wang, Wen-Zhuo He, Yu-Ming Rong, Ping Chen, Qiong Yang, Lin Yang, Bei Zhang, Xiao-Jun Xia, Peng-Fei Kong and Liang-Ping Xia

    Citation: Journal of Translational Medicine 2018 16:195

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  30. Content type: Review

    Germline mutations in the BRCA-1 associated tumor protein 1 (BAP1) increase susceptibility to mesothelioma and other cancers. We describe a patient with a family history of peritoneal mesothelioma, who develop...

    Authors: Muaiad Kittaneh and Charles Berkelhammer

    Citation: Journal of Translational Medicine 2018 16:194

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  31. Content type: Research

    Spinal cord injury (SCI) is one of the most severe central nervous system injuries. Currently, transplanting bone marrow mesenchymal stem cells (BMSCs) is considered a therapeutic option for SCI. Tanshinone II...

    Authors: Xue-Mei Zhang, Jiao Ma, Yang Sun, Bing-Qian Yu, Zhuo-Min Jiao, Duo Wang, Mei-Yu Yu, Jin-Yue Li and Jin Fu

    Citation: Journal of Translational Medicine 2018 16:193

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  32. Content type: Research

    Fatigue is a common problem among individuals with Parkinson’s disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD...

    Authors: Raymond Chong, Lauren Albor, Chandramohan Wakade and John Morgan

    Citation: Journal of Translational Medicine 2018 16:192

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  33. Content type: Research

    The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been se...

    Authors: Andrew J. Pellatt, Lila E. Mullany, Jennifer S. Herrick, Lori C. Sakoda, Roger K. Wolff, Wade S. Samowitz and Martha L. Slattery

    Citation: Journal of Translational Medicine 2018 16:191

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  34. Content type: Research

    Endoplasmic reticulum (ER) stress and its consequent unfolded protein response (UPR) are believed to be associated with progression, survival and chemoresistance of a variety of tumor cells through multiple ce...

    Authors: Prakash C. Thakur, Jennifer L. Miller-Ocuin, Khanh Nguyen, Rina Matsuda, Aatur D. Singhi, Herbert J. Zeh and Nathan Bahary

    Citation: Journal of Translational Medicine 2018 16:190

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  35. Content type: Research

    γδ T cells are associated with the pathogenesis of coronary atherosclerotic heart disease, but the relationship between the development of acute myocardial infarction (AMI) and γδ T cells is not clear. So we a...

    Authors: Xiao-ming Chen, Tao Zhang, Dan Qiu, Jian-yi Feng, Zhen-yi Jin, Qiang Luo, Xin-yu Wang and Xiu-li Wu

    Citation: Journal of Translational Medicine 2018 16:189

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  36. Content type: Research

    Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation. We chose miRNAs ...

    Authors: Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning and Shu Wang

    Citation: Journal of Translational Medicine 2018 16:188

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  37. Content type: Research

    Approximately 30% of rheumatoid arthritis (RA) patients treated with Tripterysium glycosides (TG) tablets fail to achieve clinical improvement, implying the essentiality of predictive biomarkers and tools. Her...

    Authors: Yanqiong Zhang, Hailong Wang, Xia Mao, Qiuyan Guo, Weijie Li, Xiaoyue Wang, Guangyao Li and Na Lin

    Citation: Journal of Translational Medicine 2018 16:187

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  38. Content type: Research

    Implantation failure is not only a major cause of early pregnancy loss, but it is also an obstacle to assisted reproductive technologies. The identification of potential circulating biomarkers for recurrent mi...

    Authors: Qian Yang, Wen-Wen Gu, Yan Gu, Na-Na Yan, Yan-Yan Mao, Xing-Xing Zhen, Jian-Mei Wang, Jing Yang, Hui-Juan Shi, Xuan Zhang and Jian Wang

    Citation: Journal of Translational Medicine 2018 16:186

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  39. Content type: Research

    Carcinoma of unknown primary (CUP) is a metastatic epithelial malignancy in the absence of an identifiable primary tumour. Prognosis for patients with CUP is poor because treatment options are generally limite...

    Authors: B. Clynick, B. Dessauvagie, G. Sterrett, N. T. Harvey, R. J. N. Allcock, C. Saunders, W. Erber and K. Meehan

    Citation: Journal of Translational Medicine 2018 16:185

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  40. Content type: Research

    We previously reported early on-treatment significant modulation in circulating regulatory T cell (Treg), myeloid derived suppressor cells (MDSC) and antigen-specific type I CD4+ and CD8+ T cells that correlat...

    Authors: Janet Retseck, Alexis Nasr, Yan Lin, Huang Lin, Prateek Mendiratta, Lisa H. Butterfield and Ahmad A. Tarhini

    Citation: Journal of Translational Medicine 2018 16:184

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  41. Content type: Research

    The functions of the protein expressed in the nucleus and cytoplasm were different or opposite. The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. Cetux...

    Authors: Xiqing Li, Zunlan Zhao, Shijiang Yi, Lei Ma, Ming Li, Mingyue Liu, Yaping Zhang and Guangzhi Liu

    Citation: Journal of Translational Medicine 2018 16:183

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  42. Content type: Research

    Patients with brain tumor or pancreatic cancer exhibit the poorest prognosis, while immune fitness and cellular immune exhaustion impacts their survival immensely. This work identifies differences in the immun...

    Authors: Zhenjiang Liu, Thomas Poiret, Qingda Meng, Martin Rao, Anna von Landenberg, Esther Schoutrop, Davide Valentini, Ernest Dodoo, Inti Peredo-Harvey and Markus Maeurer

    Citation: Journal of Translational Medicine 2018 16:182

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  43. Content type: Research

    Evidences in literature strongly advocate the potential of immunomodulatory peptides for use as vaccine adjuvants. All the mechanisms of vaccine adjuvants ensuing immunostimulatory effects directly or indirect...

    Authors: Gandharva Nagpal, Kumardeep Chaudhary, Piyush Agrawal and Gajendra P. S. Raghava

    Citation: Journal of Translational Medicine 2018 16:181

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  44. Content type: Correction

    Following publication of the original article [1], a typesetting mistake is reported. For Fig. 7b, a copy of Fig. 6b has been published. The correct Fig. 7b is given in this correction and the original article...

    Authors: Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz and Zsuzsanna Varga

    Citation: Journal of Translational Medicine 2018 16:180

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    The original article was published in Journal of Translational Medicine 2018 16:118

  45. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the auth...

    Authors: Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken…

    Citation: Journal of Translational Medicine 2018 16:179

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    The original article was published in Journal of Translational Medicine 2018 16:142

  46. Content type: Research

    Hepatitis C virus (HCV) treatment regimens (DAAs) are well tolerated, efficacious but costly. Their high cost and restricted availability, raises concerns about the outcome of treatment in uninsured patients. ...

    Authors: Alexandra DeBose-Scarlett, Raymond Balise, Deukwoo Kwon, Susan Vadaparampil, Steven Xi Chen, Eugene R. Schiff, Gladys Patricia Ayala and Emmanuel Thomas

    Citation: Journal of Translational Medicine 2018 16:178

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  47. Content type: Research

    Tumor-associated (TA) autoantibodies, which are generated by the immune system upon the recognition of abnormal TA antigens, are promising biomarkers for the early detection of tumors. In order to detect autoa...

    Authors: Hai-Min Hwang, Chang-Kyu Heo, Hye Jung Lee, Sang-Seob Kwak, Won-Hee Lim, Jong-Shin Yoo, Dae-Yuel Yu, Kook Jin Lim, Jeong-Yoon Kim and Eun-Wie Cho

    Citation: Journal of Translational Medicine 2018 16:177

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  48. Content type: Review

    Type 1 diabetes (DM1) is one of the most common chronic diseases in childhood and requires life-long insulin therapy and continuous health care support. An artificial pancreas (AP) or closed-loop system (CLS) ...

    Authors: Susanna Esposito, Elisa Santi, Giulia Mancini, Francesco Rogari, Giorgia Tascini, Giada Toni, Alberto Argentiero and Maria Giulia Berioli

    Citation: Journal of Translational Medicine 2018 16:176

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  49. Content type: Research

    Lipid intermediates produced during triacylglycerols (TAGs) synthesis and lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and development of insulin resistance. This study ai...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Sameem Banu, Mohamed Al-Emadi, Parvaneh Amani, Thomas M. Harvey, Alex S. Dömling, Aishah Latiff and Mohamed A. Elrayess

    Citation: Journal of Translational Medicine 2018 16:175

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