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  1. The discovery and development of novel treatments that harness the patient’s immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. However, not all patien...

    Authors: Paolo A. Ascierto, Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Leisha A. Emens, Robert L. Ferris, Silvia C. Formenti, Omid Hamid, Douglas B. Johnson, Tomas Kirchhoff, Christopher A. Klebanoff, Gregory B. Lesinski, Anne Monette, Bart Neyns, Kunle Odunsi…
    Citation: Journal of Translational Medicine 2023 21:488
  2. Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time point...

    Authors: Xi Zhou, Guobin Huang, Lu Wang, Yuanyuan Zhao, Junbo Li, Dong Chen, Lai Wei, Zhishui Chen and Bo Yang
    Citation: Journal of Translational Medicine 2023 21:487
  3. Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic;...

    Authors: Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu and Zhiheng Liu
    Citation: Journal of Translational Medicine 2023 21:486
  4. The nuclear factor kappa B (NFκB) regulatory pathways downstream of tumor necrosis factor (TNF) play a critical role in carcinogenesis. However, the widespread influence of NFκB in cells can result in off-targ...

    Authors: Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang and Chen-Ching Lin
    Citation: Journal of Translational Medicine 2023 21:485
  5. Viral therapies developed for cancer treatment have classically prioritized direct oncolytic effects over their immune activating properties. However, recent clinical insights have challenged this longstanding...

    Authors: Josef W. Goldufsky, Preston Daniels, Michael D. Williams, Kajal Gupta, Bruce Lyday, Tony Chen, Geeta Singh, Howard L. Kaufman, Andrew Zloza and Amanda L. Marzo
    Citation: Journal of Translational Medicine 2023 21:483
  6. The plant-based paleolithic diet (PD) and the paleolithic-like lifestyle (PLL) may reduce the risk of chronic diseases, including colorectal adenomas. These dietary and lifestyle approaches are proposed to exe...

    Authors: Yi Xiao, Yaxu Wang, Haitao Gu, Zhiquan Xu, Yunhao Tang, Hongmei He, Linglong Peng and Ling Xiang
    Citation: Journal of Translational Medicine 2023 21:482
  7. DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogene...

    Authors: Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li, Yunshuo Chen, Siqi Shang and Yueying Wang
    Citation: Journal of Translational Medicine 2023 21:481
  8. Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. T...

    Authors: Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang and Tao Li
    Citation: Journal of Translational Medicine 2023 21:480
  9. Obesity is a condition that is often associated with sleep disorders, including reduced sleep quality (SQ). Very low calorie ketogenic diet (VLCKD) has proven to be effective in the management of obesity and a...

    Authors: Luigi Barrea, Ludovica Verde, Cherubino Di Lorenzo, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2023 21:479
  10. Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been verified as effective in anti-cancer treatment, while immunos...

    Authors: Jing Wen, Dale Creaven, Xiangshu Luan and Jiemin Wang
    Citation: Journal of Translational Medicine 2023 21:478
  11. Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple bi...

    Authors: Jaydev Dave, Vineeta Jagana, Radoslav Janostiak and Malik Bisserier
    Citation: Journal of Translational Medicine 2023 21:477
  12. Dilated cardiomyopathy (DCM) is one of the most frequent causes of heart failure and heart transplantation (HTx). The genetic basis of DCM among patients undergoing HTx remains to be further studied. This stud...

    Authors: Hong Lian, Shen Song, Wenzheng Chen, Anteng Shi, Haobin Jiang and Shengshou Hu
    Citation: Journal of Translational Medicine 2023 21:476
  13. Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur. Epithelial-mesenchymal transition (EMT) drive...

    Authors: Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong…
    Citation: Journal of Translational Medicine 2023 21:475
  14. The glycosyltransferase CHSY3 is a CHSY family member, yet its importance in the context of gastric cancer development remains incompletely understood. The present study was thus developed to explore the mecha...

    Authors: Xinkun Huang, Yonghui Liu, Chenyu Qian, Qicheng Shen, Menglong Wu, Bin Zhu and Ying Feng
    Citation: Journal of Translational Medicine 2023 21:474
  15. Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlyin...

    Authors: Shyng-Shiou F. Yuan, Yun-Ming Wang, Leong-Perng Chan, Amos C. Hung, Hieu D. H. Nguyen, Yuk-Kwan Chen, Stephen Chu‐Sung Hu, Steven Lo and Yen-Yun Wang
    Citation: Journal of Translational Medicine 2023 21:473
  16. Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue damage during liver ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) ha...

    Authors: Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo and Peng Zhu
    Citation: Journal of Translational Medicine 2023 21:472
  17. Blood biomarkers for multiple pathways, such as inflammatory response, lipid metabolism, and hormonal regulation, have been suggested to influence the risk of mortality. However, few studies have systematicall...

    Authors: Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin and Dong Hang
    Citation: Journal of Translational Medicine 2023 21:471
  18. The tumor-adipose microenvironment (TAME) is characterized by the enrichment of adipocytes, and is considered a special ecosystem that supports cancer progression. However, the heterogeneity and diversity of a...

    Authors: Si-Qing Liu, Ding-Yuan Chen, Bei Li, Zhi-Jie Gao, Hong-Fang Feng, Xin Yu, Zhou Liu, Yuan Wang, Wen-Ge Li, Si Sun, Sheng-Rong Sun and Qi Wu
    Citation: Journal of Translational Medicine 2023 21:470
  19. The protective effect of a higher ideal cardiovascular health (CVH) score on cardiovascular diseases (CVDs) and mortality is well recognized. However, little is known regarding the length of favorable CVH stat...

    Authors: Qiuyue Tian, Shuohua Chen, Xiaoni Meng, Haotian Wang, Cancan Li, Deqiang Zheng, Lijuan Wu, Aitian Wang, Shouling Wu and Youxin Wang
    Citation: Journal of Translational Medicine 2023 21:469
  20. Small cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy has been the backbone treatment for SC...

    Authors: Chenyue Zhang, Chenxing Zhang, Kai Wang and Haiyong Wang
    Citation: Journal of Translational Medicine 2023 21:468
  21. Immune checkpoint inhibitor therapy has revolutionized the clinical management of a diverse range of cancer types, including advanced cutaneous melanoma. While immunotherapy targeting the PD-1/PD-L1 system has...

    Authors: Yue Li, Ben Wu, Md Jakir Hossain, Lily Quagliata, Connor O’Meara, Marc R. Wilkins, Susan Corley and Levon M. Khachigian
    Citation: Journal of Translational Medicine 2023 21:467
  22. We sought to identify novel molecular subtypes of ulcerative colitis (UC) based on large-scale cohorts and establish a clinically applicable subtyping system for the precision treatment of the disease.

    Authors: Shaocong Mo, Bryan Jin, Yujen Tseng, Lingxi Lin, Lishuang Lin, Xin Shen, Huan Song, Mingjia Kong, Zhongguang Luo, Yiwei Chu, Chen Jiang, Zhiwei Cao, Jie Liu and Feifei Luo
    Citation: Journal of Translational Medicine 2023 21:466
  23. Non-invasive risk stratification contributes to the precise treatment of prostate cancer (PCa). In previous studies, lymphocyte subsets were used to differentiate between low-/intermediate-risk and high-risk P...

    Authors: Chunguang Yang, Zhenghao Liu, Yin Fang, Xinyu Cao, Guoping Xu, Zhihua Wang, Zhiquan Hu, Shaogang Wang and Xinglong Wu
    Citation: Journal of Translational Medicine 2023 21:465
  24. Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–co...

    Authors: Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu and Xinghua Shan
    Citation: Journal of Translational Medicine 2023 21:464
  25. The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, go...

    Authors: Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang and Xuejun Zeng
    Citation: Journal of Translational Medicine 2023 21:463
  26. Great progress has been made in applying immunotherapy to the clinical treatment of tumors. However, many patients with triple-negative breast cancer (TNBC) cannot benefit from immunotherapy due to the immune ...

    Authors: Hongpei Tan, Jiahao Liu, Jing Huang, Yanan Li, Qiongxuan Xie, Yuqian Dong, Ze Mi, Xiaoqian Ma and Pengfei Rong
    Citation: Journal of Translational Medicine 2023 21:462
  27. Nearly 80% of patients with pancreatic cancer suffer from glucose intolerance or diabetes. Pancreatic cancer complicated by diabetes has a more immunosuppressive tumor microenvironment (TME) and is associated ...

    Authors: Chenggang Gao, Jiaoshun Chen, Jianwei Bai, Haoxiang Zhang, Yanyi Tao, Shihong Wu, Hehe Li, Heshui Wu, Qiang Shen and Tao Yin
    Citation: Journal of Translational Medicine 2023 21:461
  28. Duchenne muscular dystrophy (DMD) is an X-linked, incurable, degenerative neuromuscular disease that is exacerbated by secondary inflammation. N6-methyladenosine (m6A), the most common base modification of RNA, h...

    Authors: Xu Han, Guang Ji, Ning Wang, Le Yi, Yafei Mao, Jinliang Deng, Hongran Wu, Shaojuan Ma, Jingzhe Han, Yi Bu, Pingping Fang, Juyi Liu, Fanzhe Sun and Xueqin Song
    Citation: Journal of Translational Medicine 2023 21:459
  29. Alzheimer's disease (AD) is the most common neurodegenerative disease. Mitochondrial dysfunction and immune responses are important factors in the pathogenesis of AD, but their crosstalk in AD has not been stu...

    Authors: Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:458
  30. Each step in angiogenesis is regulated by the extracellular matrix (ECM). Accumulating evidence indicates that ageing-related changes in the ECM driven by cellular senescence lead to a reduction in neovascular...

    Authors: Ping Xiao, Yanli Zhang, Yuting Zeng, Dehong Yang, Jiayao Mo, Ziting Zheng, Jilei Wang, Yuxin Zhang, Zhiyan Zhou, Xincen Zhong and Wenjuan Yan
    Citation: Journal of Translational Medicine 2023 21:457
  31. Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in which serous ovarian carcinoma (SOC) is the most common histological subtype. Although PARP inhibitors (PARPi) and antiangiog...

    Authors: Xiaohui Yang, Minying Zheng, Yidi Ning, Jie Sun, Yongjun Yu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:456
  32. In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, sp...

    Authors: Liangliang Zhao, Haitao Xu, Xin Liu, Yan Cheng and Jia’nan Xie
    Citation: Journal of Translational Medicine 2023 21:455
  33. The prevalence of hypertension in Qatar is 33 percent of the adult population. It is postulated that the salivary microbiome can regulate blood pressure (BP). However, limited investigations exist to prove thi...

    Authors: Selvasankar Murugesan and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2023 21:454
  34. USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51 contributes to cancer development. However, its impact on non-small cell lung ...

    Authors: Jin Chen, Zhongqiu Wu, Wenyi Deng, Minying Tang, Lvying Wu, Na Lin, Liuyan Chen, Yunfeng Fu, Min Zhao, Changguo Chen and Wenting Li
    Citation: Journal of Translational Medicine 2023 21:453
  35. Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targ...

    Authors: Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang and Liulong Zhu
    Citation: Journal of Translational Medicine 2023 21:452
  36. Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess ...

    Authors: Yinhua Huang, Zhijie Wang, Bo Ye, Jacey Hongjie MA, Shangli Ji, Wang Sheng, Suna Ye, Yiwen Ou, Yanfang Peng, Xu Yang, Jiansu Chen and Shibo Tang
    Citation: Journal of Translational Medicine 2023 21:451
  37. Glioma grade 4 (GG4) tumors, including astrocytoma IDH-mutant grade 4 and the astrocytoma IDH wt are the most common and aggressive primary tumors of the central nervous system. Surgery followed by Stupp proto...

    Authors: Michele Dal Bo, Maurizio Polano, Tamara Ius, Federica Di Cintio, Alessia Mondello, Ivana Manini, Enrico Pegolo, Daniela Cesselli, Carla Di Loreto, Miran Skrap and Giuseppe Toffoli
    Citation: Journal of Translational Medicine 2023 21:450
  38. Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize ...

    Authors: Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh…
    Citation: Journal of Translational Medicine 2023 21:449

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:571

  39. There are emerging studies suggesting that non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with multiple etiologies and molecular phenotypes. Fibrosis is the key process in NAFLD progressi...

    Authors: Weiwei He, Yinxiang Huang, Xiulin Shi, Qingxuan Wang, Menghua Wu, Han Li, Qiuhong Liu, Xiaofang Zhang, Caoxin Huang and Xuejun Li
    Citation: Journal of Translational Medicine 2023 21:448
  40. The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-establishe...

    Authors: Xiaohao Ruan, Da Huang, Jingyi Huang, James Hok-Leung Tsu and Rong Na
    Citation: Journal of Translational Medicine 2023 21:446
  41. Prostate cancer (PCa) is a prevalent malignant disease affecting a significant number of males globally. Elevated expression of the Bloom’s syndrome protein (BLM) helicase has emerged as a promising cancer bio...

    Authors: Mengqiu Huang, Lin Chen, Yingchu Guo, Yong Ruan and Houqiang Xu
    Citation: Journal of Translational Medicine 2023 21:445
  42. Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity...

    Authors: Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K. Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M. Ahmed, Vita S. Salsman, Patricia A. Baxter, Jack M. Su, Daniel J. Brat…
    Citation: Journal of Translational Medicine 2023 21:444
  43. Aberrant ubiquitin-proteasome system (UPS) triggers various disorders of biological events and contributes to progression of tumorigenesis. The tripartite motif containing 22 (TRIM22) was demonstrated to parti...

    Authors: Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan and Qihong Qian
    Citation: Journal of Translational Medicine 2023 21:443
  44. This systematic review and meta-analysis study aimed to evaluate the effectiveness of probiotics supplementation on glycaemic control in patients with type 2 diabetes mellitus (T2DM) based on the data from the...

    Authors: Guang Li, Hao Feng, Xin-Liang Mao, Yan-Jun Deng, Xiao-Bao Wang, Qiong Zhang, Yan Guo and Su-Mei Xiao
    Citation: Journal of Translational Medicine 2023 21:442
  45. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial illness that affects many body systems including the immune, nervous, endocrine, cardiovascular, and urinary systems. There is cu...

    Authors: Asher Taccori, Rebekah Maksoud, Natalie Eaton-Fitch, Maharshi Patel and Sonya Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2023 21:440
  46. Recent studies have uncovered that the microbiota in patients with head and neck cancers is significantly altered and may drive cancer development. However, there is limited data to explore the unique microbio...

    Authors: Shuting Yu, Junru Chen, Yan Zhao, Fangxu Yan, Yue Fan, Xin Xia, Guangliang Shan, Peng Zhang and Xingming Chen
    Citation: Journal of Translational Medicine 2023 21:438
  47. Impaired sensitivity to thyroid hormones is a newly proposed clinical entity associated with hyperuricemia in the subclinical hypothyroid population. However, it is unknown whether the association exists in th...

    Authors: Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, Bo Gao and Xiuhua Guo
    Citation: Journal of Translational Medicine 2023 21:436

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