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  1. Immune-related genes (IRGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of IRGs and their clinical significance in s...

    Authors: Chuan Hu, Bo Chen, Zhangheng Huang, Chuan Liu, Lin Ye, Cailin Wang, Yuexin Tong, Jiaxin Yang and Chengliang Zhao

    Citation: Journal of Translational Medicine 2020 18:337

    Content type: Research

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  2. Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have bee...

    Authors: Zack Y. Shan, Leighton R. Barnden, Richard A. Kwiatek, Sandeep Bhuta, Daniel F. Hermens and Jim Lagopoulos

    Citation: Journal of Translational Medicine 2020 18:335

    Content type: Review

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  3. African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular ba...

    Authors: Xuan Yang, Mohamed Amgad, Lee A. D. Cooper, Yuhong Du, Haian Fu and Andrey A. Ivanov

    Citation: Journal of Translational Medicine 2020 18:334

    Content type: Research

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  4. Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation.

    Authors: Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng and Ming Yan

    Citation: Journal of Translational Medicine 2020 18:332

    Content type: Research

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  5. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd

    Citation: Journal of Translational Medicine 2020 18:330

    Content type: Research

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  6. The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

    Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:329

    Content type: Research

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  7. Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...

    Authors: Zhihong Weng, Qiaosen Chen, Sumeng Li, Huadong Li, Qian Zhang, Sihong Lu, Li Wu, Leiqun Xiong, Bobin Mi, Di Liu, Mengji Lu, Dongliang Yang, Hongbo Jiang, Shaoping Zheng and Xin Zheng

    Citation: Journal of Translational Medicine 2020 18:328

    Content type: Research

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  8. Liver cancer is among the most common malignancy worldwide. Hepatocellular carcinoma (HCC), the principal histological subtype of liver cancer, is globally the third most common cause of cancer-related mortali...

    Authors: Xia Qin, Jian Zhang, Yu Lin, Xue-ming Sun, Jia-ning Zhang and Zhi-qiang Cheng

    Citation: Journal of Translational Medicine 2020 18:326

    Content type: Research

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  9. Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by extracellular plaques, intracellular neurofibrillary tangles and neuronal loss in the central nervous system (CNS). Pathogens a...

    Authors: Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Mario Clerici and Janardan P. Pandey

    Citation: Journal of Translational Medicine 2020 18:325

    Content type: Research

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  10. Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) and tumor mutational burden (TMB) have been proved to play crucial roles in predicting clinical ou...

    Authors: Xinyi Wang, Jinzhong Duanmu, Xiaorui Fu, Taiyuan Li and Qunguang Jiang

    Citation: Journal of Translational Medicine 2020 18:324

    Content type: Research

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  11. Serum cell-free DNA (cfDNA) holds promise as a non-invasive cancer biomarker. The objective of this study was to evaluate the association of cfDNA concentration with clinicopathologic variables of poor prognos...

    Authors: Gregory M. Gressel, Elaine C. Maggi, Bryan E. Harmon, Kenny Q. Ye, D. Y. S. Kuo, Siobhan M. Dolan and Cristina Montagna

    Citation: Journal of Translational Medicine 2020 18:323

    Content type: Research

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  12. The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4...

    Authors: Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau and Huynh Cao

    Citation: Journal of Translational Medicine 2020 18:322

    Content type: Review

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  13. The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiote...

    Authors: Xingyi Guo, Zhishan Chen, Yumin Xia, Weiqiang Lin and Hongzhi Li

    Citation: Journal of Translational Medicine 2020 18:321

    Content type: Research

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  14. Previous findings have indicated that the tumor, nodes, and metastases (TNM) staging system is not sufficient to accurately predict survival outcomes in patients with non-small lung carcinoma (NSCLC). Thus, th...

    Authors: Rui-Qi Wang, Xiao-Ran Long, Chun-Lei Ge, Mei-Yin Zhang, Long Huang, Ning-Ning Zhou, Yi Hu, Rui-Lei Li, Zhen Li, Dong-Ni Chen, Lan-Jun Zhang, Zhe-Sheng Wen, Shi-Juan Mai and Hui-Yun Wang

    Citation: Journal of Translational Medicine 2020 18:320

    Content type: Research

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  15. In less than 20 years, three deadly coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2, have emerged in human population causing hundreds to hundreds of thousands of deaths. Other coronaviruses are causing epizo...

    Authors: Laure Perrin-Cocon, Olivier Diaz, Clémence Jacquemin, Valentine Barthel, Eva Ogire, Christophe Ramière, Patrice André, Vincent Lotteau and Pierre-Olivier Vidalain

    Citation: Journal of Translational Medicine 2020 18:319

    Content type: Review

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  16. COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass ...

    Authors: Luigi Barrea, Gabriella Pugliese, Lydia Framondi, Rossana Di Matteo, Daniela Laudisio, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri

    Citation: Journal of Translational Medicine 2020 18:318

    Content type: Research

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  17. To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

    Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2020 18:317

    Content type: Research

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  18. Antibody based cancer therapies have achieved convincing success rates combining enhanced tumor specificity and reduced side effects in patients. Trastuzumab that targets the human epidermal growth factor rela...

    Authors: Anja Kathrin Wege, Nicole Kirchhammer, Linda Veronique Kazandjian, Sandra Prassl, Michael Brandt, Gerhard Piendl, Olaf Ortmann, Stephan Fischer and Gero Brockhoff

    Citation: Journal of Translational Medicine 2020 18:316

    Content type: Research

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  19. In the rapidly evolving coronavirus disease 2019 (COVID-19) outbreak, inherent literature has been increasing at an impressive rate. Such a dynamic scenario imposes the necessity to define a new framework for ...

    Authors: Maddalena Barba, Eriseld Krasniqi, Gennaro Ciliberto and Patrizia Vici

    Citation: Journal of Translational Medicine 2020 18:315

    Content type: Commentary

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  20. Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity o...

    Authors: Jihyun Lee, Suzanne D. Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman and Lucinda Bateman

    Citation: Journal of Translational Medicine 2020 18:314

    Content type: Research

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  21. Lung cancer is one of the most common carcinomas in the world, and lung adenocarcinoma (LUAD) is the most lethal and most common subtype of lung cancer. Cigarette smoking is the most leading risk factor of lun...

    Authors: Jin Wang, Tao Chen, Xiaofan Yu, Nan OUYang, Lirong Tan, Beibei Jia, Jian Tong and Jianxiang Li

    Citation: Journal of Translational Medicine 2020 18:313

    Content type: Research

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qibin Liao, Jin Wang, Zenglin Pei, Jianqing Xu and Xiaoyan Zhang

    Citation: Journal of Translational Medicine 2020 18:312

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2017 15:41

  23. Endometriosis is a chronic inflammatory hormone-dependent condition associated with pelvic pain and infertility, characterized by the growth of ectopic endometrium outside the uterus. Given its still unknown e...

    Authors: Helena Malvezzi, Eliana Blini Marengo, Sérgio Podgaec and Carla de Azevedo Piccinato

    Citation: Journal of Translational Medicine 2020 18:311

    Content type: Review

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  24. HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cel...

    Authors: Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug and Laurence Briant

    Citation: Journal of Translational Medicine 2020 18:310

    Content type: Research

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  25. The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospin...

    Authors: Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze and Ajay Verma

    Citation: Journal of Translational Medicine 2020 18:309

    Content type: Research

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  26. Necrotizing enterocolitis (NEC) is one of the most severe complications in very preterm infants, but there are currently no accepted methods to prevent NEC. Studies have shown that erythropoietin (EPO) has the...

    Authors: Yong Wang, Juan Song, Huiqing Sun, Falin Xu, Kenan Li, Chunxia Nie, Xiaoli Zhang, Xirui Peng, Lei Xia, Ziyun Shen, Xiao Yuan, Shan Zhang, Xue Ding, Yaodong Zhang, Wenqing Kang, Liling Qian…

    Citation: Journal of Translational Medicine 2020 18:308

    Content type: Research

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  27. Treatment of human lung squamous cell carcinoma (LUSC) using current targeted therapies is limited because of their diverse somatic mutations without any specific dominant driver mutations. These mutational di...

    Authors: Hae-Yun Jung, Tae Ho Kim, Jong-Eun Lee, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sumin Shin, Se-Hoon Lee, Hwanseok Rhee, Hee Kyung Lee, Hyun Jung Choi, Hye Yoon Jang, Seungjae Lee, Jung Hee Kang, Young Ae Choi, Sanghyuk Lee…

    Citation: Journal of Translational Medicine 2020 18:307

    Content type: Research

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  28. Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1)...

    Authors: Mengzhou Guo, Feifei Yuan, Feng Qi, Jialei Sun, Qianwen Rao, Zhiying Zhao, Peixin Huang, Tingting Fang, Biwei Yang and Jinglin Xia

    Citation: Journal of Translational Medicine 2020 18:306

    Content type: Research

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  29. Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not f...

    Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

    Citation: Journal of Translational Medicine 2020 18:305

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2020 18:368

  30. Bladder cancer (BlCa) taxonomy has proved its impact in patient outcome and selection for targeted therapies, but such transcriptomic-based classification has not yet translated to routine practice. Moreover, ...

    Authors: João Lobo, Sara Monteiro-Reis, Catarina Guimarães-Teixeira, Paula Lopes, Isa Carneiro, Carmen Jerónimo and Rui Henrique

    Citation: Journal of Translational Medicine 2020 18:303

    Content type: Research

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  31. In the last twenty years, several studies have been conducted in the search for new therapeutic strategies in patients with food allergy; in particular, after the failure of injection immunotherapy, three diff...

    Authors: Francesco Marcucci, Chiara Isidori, Alberto Argentiero, Cosimo Neglia and Susanna Esposito

    Citation: Journal of Translational Medicine 2020 18:302

    Content type: Review

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  32. Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-dependent macrophage pyroptosis contributes to organ damage caused by ischem...

    Authors: Lin Fei, Xiao Jingyuan, Liang Fangte, Dai Huijun, Ye Liu, Jing Ren, Lin Jinyuan and Pan Linghui

    Citation: Journal of Translational Medicine 2020 18:301

    Content type: Research

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  33. Deceased organ donors represent an untapped source of therapeutic bone marrow (BM) that can be recovered in 3–5 times the volume of that obtained from living donors, tested for quality, cryopreserved, and bank...

    Authors: Erik J. Woods, Aubrey M. Sherry, John R. Woods, James W. Hardin, Michael LaFontaine, Gerald Brandacher and Brian H. Johnstone

    Citation: Journal of Translational Medicine 2020 18:300

    Content type: Research

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  34. Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is th...

    Authors: Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta and Paola Gualtieri

    Citation: Journal of Translational Medicine 2020 18:299

    Content type: Research

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  35. The increased bone marrow angiogenesis is involved in the progression of multiple myeloma (MM) with the underlying mechanism poorly understood. Cancer-released exosomes could play an important role in the path...

    Authors: Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu and Qian Cheng

    Citation: Journal of Translational Medicine 2020 18:298

    Content type: Research

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  36. The severe acute respiratory syndrome virus SARS-CoV-2, a close relative of the SARS-CoV virus, is the cause of the recent COVID-19 pandemic affecting, to date, over 14 million individuals across the globe and...

    Authors: Nophar Geifman and Anthony D. Whetton

    Citation: Journal of Translational Medicine 2020 18:297

    Content type: Research

    Published on:

  37. Ischemic stroke (IS) is the second leading cause of death worldwide which is a serious hazard to human health. Evidence suggests that the immune system plays a key role in the pathophysiology of IS. However, t...

    Authors: Zijian Li, Yueran Cui, Juan Feng and Yanxia Guo

    Citation: Journal of Translational Medicine 2020 18:296

    Content type: Research

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  38. Treatment of hepatocellular carcinoma (HCC) using antibody-based targeted therapies, such as antibody conjugates and chimeric antigen receptor T (CAR-T) cell therapy, shows potent antitumor efficacy. Glypican-...

    Authors: Xiaoyu Liu, Fang Gao, Longwei Jiang, Meng Jia, Lei Ao, Ming Lu, Liming Gou, Mitchell Ho, Shaochang Jia, Fei Chen and Wei Gao

    Citation: Journal of Translational Medicine 2020 18:295

    Content type: Research

    Published on:

  39. We sought to identify patient subgroups with distinct postprogression overall survival (ppOS) outcomes and investigate the impact of original treatment assignment and initial postprogression treatment (ppRx) o...

    Authors: Paolo A. Ascierto, Antoni Ribas, James Larkin, Grant A. McArthur, Karl D. Lewis, Axel Hauschild, Keith T. Flaherty, Edward McKenna, Qian Zhu, Yong Mun and Brigitte Dréno

    Citation: Journal of Translational Medicine 2020 18:294

    Content type: Research

    Published on:

  40. Circulating tumor DNA (ctDNA) offers a convenient way to monitor tumor progression and treatment response. Because tumor mutational profiles are highly variable from person to person, a fixed content panel may...

    Authors: Jiaping Li, Wei Jiang, Jinwang Wei, Jianwei Zhang, Linbo Cai, Minjie Luo, Zhan Wang, Wending Sun, Shengzhou Wang, Chen Wang, Chun Dai, Jun Liu, Guan Wang, Jiping Wang, Qiang Xu and Yanhong Deng

    Citation: Journal of Translational Medicine 2020 18:293

    Content type: Research

    Published on:

  41. Measuring the DNA methylome may offer the opportunity to identify novel disease biomarkers and insights into disease mechanisms. Although aberrant DNA methylation has been investigated in many human cancers an...

    Authors: Runhua Lin, Chenxi Li, Zhaohui Liu, Ruinuan Wu and Jianghong Lu

    Citation: Journal of Translational Medicine 2020 18:292

    Content type: Research

    Published on:

  42. Covid-19 morbidity and mortality are associated with a dysregulated immune response. Tools are needed to enhance existing immune profiling capabilities in affected patients. Here we aimed to develop an approac...

    Authors: Darawan Rinchai, Basirudeen Syed Ahamed Kabeer, Mohammed Toufiq, Zohreh Tatari-Calderone, Sara Deola, Tobias Brummaier, Mathieu Garand, Ricardo Branco, Nicole Baldwin, Mohamed Alfaki, Matthew C. Altman, Alberto Ballestrero, Matteo Bassetti, Gabriele Zoppoli, Andrea De Maria, Benjamin Tang…

    Citation: Journal of Translational Medicine 2020 18:291

    Content type: Research

    Published on:

  43. Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) present with a constellation of symptoms including debilitating fatigue that is unrelie...

    Authors: Sean Holden, Rebekah Maksoud, Natalie Eaton-Fitch, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2020 18:290

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:407

  44. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown causes. From the perspectives on the etiology and pathophysiology, ME/CFS has been labeled differently, which ...

    Authors: Eun-Jin Lim and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:289

    Content type: Review

    Published on:

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2020 18:447

  45. Defining and protecting participants’ rights is the aim of several ethical codices and legal regulations. According to these regulations, the Informed Consent (IC) is an inevitable element of research with hum...

    Authors: Henriette Rau, Lars Geidel, Martin Bialke, Arne Blumentritt, Martin Langanke, Wenke Liedtke, Sandra Pasewald, Dana Stahl, Thomas Bahls, Christian Maier, Hans-Ulrich Prokosch and Wolfgang Hoffmann

    Citation: Journal of Translational Medicine 2020 18:287

    Content type: Research

    Published on:

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