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  1. Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and e...

    Authors: Chuan Qin, Xin-Ling Zhao, Xiao-Tong Ma, Luo-Qi Zhou, Long-jun Wu, Ke Shang, Wei Wang and Dai-Shi Tian

    Citation: Journal of Translational Medicine 2019 17:214

    Content type: Research

    Published on:

  2. Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. Th...

    Authors: Tiansong Yang, Yan Yang, Delong Wang, Chaoran Li, Yuanyuan Qu, Jing Guo, Tianyu Shi, Wang Bo, Zhongren Sun and Tetsuya Asakawa

    Citation: Journal of Translational Medicine 2019 17:213

    Content type: Review

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  3. Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome, characterized by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. Despite several genetic ...

    Authors: Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz…

    Citation: Journal of Translational Medicine 2019 17:212

    Content type: Research

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  4. Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells (BMSC-EVs) can play important roles in the repair of injured tissues. However, no reports have investigated the role and un...

    Authors: Zhengzhou Shi, Qi Wang and Dapeng Jiang

    Citation: Journal of Translational Medicine 2019 17:211

    Content type: Research

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  5. Glioma is the most common primary malignant brain tumor in adults with a poor prognosis. ARL3 is a member of the ARF family, and plays a key role in ciliary function and lipid-modified protein trafficking. ARL...

    Authors: Yulin Wang, Weijiang Zhao, Xin Liu, Gefei Guan and Minghua Zhuang

    Citation: Journal of Translational Medicine 2019 17:210

    Content type: Research

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  6. Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, b...

    Authors: Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu and Eva Colas

    Citation: Journal of Translational Medicine 2019 17:208

    Content type: Research

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  7. Head and neck squamous cell carcinoma (HNSCC) originates from squamous epithelium of the upper aerodigestive tract and is the most common malignancy in the head and neck region. Among HNSCCs, oropharynx squamo...

    Authors: Yui Hirata-Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis…

    Citation: Journal of Translational Medicine 2019 17:207

    Content type: Research

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  8. Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limit...

    Authors: Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin and Sarkis Meterissian

    Citation: Journal of Translational Medicine 2019 17:206

    Content type: Research

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  9. In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral...

    Authors: Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry and Sajjad Muhammad

    Citation: Journal of Translational Medicine 2019 17:205

    Content type: Research

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  10. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of early diagnosis and prediction for acute kidney injury (AKI). However, the current program for NGAL detection is not extensively ap...

    Authors: Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu and Xiaopeng Lan

    Citation: Journal of Translational Medicine 2019 17:204

    Content type: Research

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  11. Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge to determine patients’ prognosis. We aim to identify new prognostic markers for resected HCC patients.

    Authors: Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu and Zhi Dai

    Citation: Journal of Translational Medicine 2019 17:203

    Content type: Research

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  12. Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors.

    Authors: Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li and Yaogang Wang

    Citation: Journal of Translational Medicine 2019 17:202

    Content type: Research

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  13. The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has bee...

    Authors: Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta and Joyce Schroeder

    Citation: Journal of Translational Medicine 2019 17:201

    Content type: Research

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  14. “Nanomedicine” is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While “...

    Authors: Jie Feng, Chester E. Markwalter, Chang Tian, Madeleine Armstrong and Robert K. Prud’homme

    Citation: Journal of Translational Medicine 2019 17:200

    Content type: Research

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  15. Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammatio...

    Authors: Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto and Markus J. Mäkinen

    Citation: Journal of Translational Medicine 2019 17:199

    Content type: Research

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  16. Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different ...

    Authors: Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza and Luis Villela

    Citation: Journal of Translational Medicine 2019 17:198

    Content type: Research

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  17. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular sensors of pathogens and molecules from damaged cells to regulate the inflammatory response in the innate immune system. ...

    Authors: Luo-Yi Wang, Xiao-Jing Sun, Min Chen and Ming-Hui Zhao

    Citation: Journal of Translational Medicine 2019 17:197

    Content type: Research

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  18. Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the ...

    Authors: N. Kojima, J. C. Siebert, H. Maecker, Y. Rosenberg-Hasson, S. R. Leon, S. K. Vargas, K. A. Konda, C. F. Caceres and J. D. Klausner

    Citation: Journal of Translational Medicine 2019 17:196

    Content type: Research

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  19. Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use is limited by its side effects mostly arising from a relatively low boiling point (55 °C). In t...

    Authors: Ho Joong Choi, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Ha-Eun Hong, Sang Chul Lee, Kee-Hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho Hong, Eun Young Kim, Jung Hyun Park, Gun Hyung Na, Dong Do You, Jae Hyun Han, Jae Woo Park…

    Citation: Journal of Translational Medicine 2019 17:195

    Content type: Research

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  20. One main challenge in ovarian cancer rests on the presence of a relapse and an important metastatic disease, despite extensive surgical debulking and chemotherapy. The difficulty in containing metastatic cance...

    Authors: Jessica Hoarau-Véchot, Cyril Touboul, Najeeb Halabi, Morgane Blot-Dupin, Raphael Lis, Charbel Abi Khalil, Shahin Rafii, Arash Rafii and Jennifer Pasquier

    Citation: Journal of Translational Medicine 2019 17:194

    Content type: Research

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  21. Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop and validate nomograms to predict lymph node metastasis (LNM) and LIM i...

    Authors: Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang and Zhiyu Xiao

    Citation: Journal of Translational Medicine 2019 17:193

    Content type: Research

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  22. Gastric cancer (GC) remains a refractory cancer worldwide. Currently, exploring the differences of the immune status in GC patients with different subgroups might provide promising immunotherapeutic approaches...

    Authors: Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao and Gang Zhao

    Citation: Journal of Translational Medicine 2019 17:192

    Content type: Research

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  23. Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value of mRNA expression...

    Authors: Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao…

    Citation: Journal of Translational Medicine 2019 17:191

    Content type: Research

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  24. Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC. Hence, the study aims to evaluate...

    Authors: Jun Dai, Rujia Wei, Peihai Zhang and Beihua Kong

    Citation: Journal of Translational Medicine 2019 17:190

    Content type: Research

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  25. Gastric cancer (GC) is a leading cause of cancer deaths, and an increased number of GC patients adopt to next-generation sequencing (NGS) to identify tumor genomic alterations for precision medicine.

    Authors: Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang, Liang Shang, Shouxin Wu, Peng Meng, Ling Lin, Jiangman Zhao, Mingming Nie…

    Citation: Journal of Translational Medicine 2019 17:189

    Content type: Research

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  26. Tumors develop by progression through a series of stages. Every cell of the tumor microenvironment is constantly changing in the flow of the cancer progression. It has become clear in recent years that stroma ...

    Authors: F. Lessi, C. Scatena, P. Aretini, M. Menicagli, S. Franceschi, A. G. Naccarato and C. M. Mazzanti

    Citation: Journal of Translational Medicine 2019 17:187

    Content type: Research

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  27. Early diagnosis is critical to reduce the mortality caused by nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs) are dysregulated and play important roles in carcinogenesis. Therefore, this study aimed to iden...

    Authors: Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang and Ling Guo

    Citation: Journal of Translational Medicine 2019 17:186

    Content type: Research

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  28. Orthostatic intolerance (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.

    Authors: Richard Garner and James N. Baraniuk

    Citation: Journal of Translational Medicine 2019 17:185

    Content type: Research

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  29. SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWA...

    Authors: Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee and Rukmini Govekar

    Citation: Journal of Translational Medicine 2019 17:184

    Content type: Research

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  30. Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitat...

    Authors: Dibyendu Dutta, Barbara Methe, Salomon Amar, Alison Morris and Seah H. Lim

    Citation: Journal of Translational Medicine 2019 17:183

    Content type: Research

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  31. Melanoma is an aggressive type of skin cancer whose aetiology remains elusive as both environmental and genetic factors can contribute to its development. Recent studies have demonstrated the existence of mult...

    Authors: Maria Santa Rocca, Clara Benna, Simone Mocellin, Carlo Riccardo Rossi, Aichi Msaki, Andrea Di Nisio, Giuseppe Opocher and Carlo Foresta

    Citation: Journal of Translational Medicine 2019 17:181

    Content type: Research

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  32. ST-segment elevation myocardial infarction (STEMI) displays circadian variability with the highest incidence in the morning hours. Data on whether the time-of-day at symptom onset affects infarct size or patie...

    Authors: Hendrik B. Sager, Oliver Husser, Sabine Steffens, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Gjin Ndrepepa and Thorsten Kessler

    Citation: Journal of Translational Medicine 2019 17:180

    Content type: Research

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  33. Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, pr...

    Authors: Siqi Wang, Fang Liu, Yuhui Wang, Wenliang Fan, Hongyang Zhao, Liying Liu, Chunyuan Cen, Xiaobin Jiang, Min Sun and Ping Han

    Citation: Journal of Translational Medicine 2019 17:179

    Content type: Research

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  34. Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney cancer in adults, and it is responsible for approximately 90–95% of cases. Although extensive evidence has suggested that many immune-...

    Authors: Enyang Zhao, Lihong Li, Wenfu Zhang, Wanhui Wang, Yunhui Chan, Bosen You and Xuedong Li

    Citation: Journal of Translational Medicine 2019 17:177

    Content type: Research

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  35. Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents ...

    Authors: Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh and Mark O. Goodarzi

    Citation: Journal of Translational Medicine 2019 17:176

    Content type: Research

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  36. In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epito...

    Authors: Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2019 17:175

    Content type: Research

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  37. Patients with X-linked agammaglobulinemia (XLA) are protected against invasive bacterial infections due to IgG replacement therapy, but are still at higher risk for mucosal infections of the gut and respirator...

    Authors: Jeroen D. Langereis, Joannes F. M. Jacobs, Marien I. de Jonge and Marcel van Deuren

    Citation: Journal of Translational Medicine 2019 17:174

    Content type: Research

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  38. Prostate cancer is an extremely heterogeneous disease. Despite being clinically similar, some tumours are more likely to recur after surgery compared to others. Distinguishing those that need adjuvant or salva...

    Authors: C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He and S. K. Liu

    Citation: Journal of Translational Medicine 2019 17:173

    Content type: Research

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  39. The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological s...

    Authors: Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli and Marco Salvatore

    Citation: Journal of Translational Medicine 2019 17:172

    Content type: Review

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  40. Predicting adverse drug reactions (ADRs) has become very important owing to the huge global health burden and failure of drugs. This indicates a need for prior prediction of probable ADRs in preclinical stages...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover and Abhinav Grover

    Citation: Journal of Translational Medicine 2019 17:171

    Content type: Research

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  41. Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...

    Authors: William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman and John J. Kopchick

    Citation: Journal of Translational Medicine 2019 17:170

    Content type: Research

    Published on:

  42. Obesity must be considered a real pathology. In the world wide, obesity represent one of the major public health issue associated with increased morbidity and mortality. Overweight or obesity, in fact, signifi...

    Authors: Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci and Laura Di Renzo

    Citation: Journal of Translational Medicine 2019 17:169

    Content type: Review

    Published on:

  43. Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate ...

    Authors: Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang and Weifan Yin

    Citation: Journal of Translational Medicine 2019 17:168

    Content type: Research

    Published on:

  44. In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease pro...

    Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang and Hong Shang

    Citation: Journal of Translational Medicine 2019 17:167

    Content type: Research

    Published on:

  45. Compared with clinically functioning pituitary adenoma (FPA), clinically non-functioning pituitary adenoma (NFPA) lacks of detectable hypersecreting serum hormones and related symptoms which make it difficult ...

    Authors: Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying and Yazhuo Zhang

    Citation: Journal of Translational Medicine 2019 17:164

    Content type: Research

    Published on:

  46. There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-solub...

    Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts and Ashok Saluja

    Citation: Journal of Translational Medicine 2019 17:163

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:301

  47. The morbidity and mortality of patients with critical illnesses remain high in pulmonary critical care units and a poorly understood correlation between alterations of lipid elements and clinical phenomes rema...

    Authors: Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:162

    Content type: Research

    Published on:

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