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  1. Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and re...

    Authors: Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang and Jianwen Wang
    Citation: Journal of Translational Medicine 2024 22:476
  2. To analyze the role of and mechanism underlying obstructive sleep apnea (OSA)-derived exosomes in inducing non-alcoholic fatty liver (NAFLD).

    Authors: Li Yang, Shijie Liu, Yan He, Lulu Gan, Qing Ni, Anni Dai, Changhuan Mu, Qian Liu, Hongyan Chen, Hongying Lu and Ruixue Sun
    Citation: Journal of Translational Medicine 2024 22:475
  3. Vessels encapsulating tumor clusters (VETC) is a newly described vascular pattern that is distinct from microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Despite its importance, the...

    Authors: Si-Ping Xiong, Chun-Hua Wang, Mei-fang Zhang, Xia Yang, Jing-Ping Yun and Li-Li Liu
    Citation: Journal of Translational Medicine 2024 22:472
  4. Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is a k...

    Authors: Yuli Ruan, Yue Ma, Ming Ma, Chao Liu, Dan Su, Xin Guan, Rui Yang, Hong Wang, Tianqin Li, Yang Zhou, Jianqun Ma and Yanqiao Zhang
    Citation: Journal of Translational Medicine 2024 22:471
  5. Colorectal cancer (CRC) remains a major global health challenge, with high incidence and mortality rates. The role of long noncoding RNAs (lncRNAs) in cancer progression has received considerable attention. Th...

    Authors: Mingkun Wang, Xuben Niu, Maihuan Wang, Peng Zheng, Xiaoya Liu, Zhen Cao and Chaojun Zhang
    Citation: Journal of Translational Medicine 2024 22:469
  6. Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC). The lac...

    Authors: Simeng Liu, Huijuan Wen, Fazhan Li, Xia Xue, Xiangdong Sun, Fuhao Li, Ruoyu Hu, Huayuan Xi, Francesco Boccellato, Thomas F Meyer, Yang Mi and Pengyuan Zheng
    Citation: Journal of Translational Medicine 2024 22:468
  7. Osteoarthritis (OA) is a chronic degenerative joint disease causing limited mobility and pain, with no curative treatment available. Recent in vivo studies suggested autonomic alterations during OA progression...

    Authors: Rebecca Sohn, Tina Assar, Isabelle Kaufhold, Marco Brenneis, Sebastian Braun, Marius Junker, Frank Zaucke, Georg Pongratz and Zsuzsa Jenei-Lanzl
    Citation: Journal of Translational Medicine 2024 22:467
  8. Neuroinflammation is a characteristic pathological change of Alzheimer’s Diseases (AD). Microglia have been reported to participate in inflammatory responses within the central nervous system. However, the mec...

    Authors: Hong Wei, Zhuzhi Zhu, Yuhao Xu, Li Lin, Qi Chen, Yueqin Liu, Yuefeng Li and Xiaolan Zhu
    Citation: Journal of Translational Medicine 2024 22:466
  9. Disturbance in mitochondrial homeostasis within proximal tubules is a critical characteristic associated with diabetic kidney disease (DKD). CaMKKβ/AMPK signaling plays an important role in regulating mitochon...

    Authors: Fei Han, Shi Wu, Ya Dong, Yanjie Liu, Bei Sun and Liming Chen
    Citation: Journal of Translational Medicine 2024 22:465
  10. Mesenchymal stem cells (MSCs) have garnered significant interest for their tumor-tropic property, making them potential therapeutic delivery vehicles for cancer treatment. We have previously shown the signific...

    Authors: Yoon Khei Ho, Jun Yung Woo, Kin Man Loke, Lih-Wen Deng and Heng-Phon Too
    Citation: Journal of Translational Medicine 2024 22:463
  11. Comprehensive next-generation sequencing is widely used for precision oncology and precision prevention approaches. We aimed to determine the yield of actionable gene variants, the capacity to uncover heredita...

    Authors: I. Vanni, L. Pastorino, V. Andreotti, D. Comandini, G. Fornarini, M. Grassi, A. Puccini, E. T. Tanda, A. Pastorino, V. Martelli, L. Mastracci, F. Grillo, F. Cabiddu, A. Guadagno, S. Coco, E. Allavena…
    Citation: Journal of Translational Medicine 2024 22:462
  12. Chaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized proteins. However, its roles and underlying mechanisms in lung adenocarcinom...

    Authors: Shao-Kun Yu, Tao Yu, Yu-Ming Wang, Ao Sun, Jia Liu and Kai-Hua Lu
    Citation: Journal of Translational Medicine 2024 22:460
  13. Corneal injuries, often leading to severe vision loss or blindness, have traditionally been treated with the belief that limbal stem cells (LSCs) are essential for repair and homeostasis, while central corneal...

    Authors: Ruijue Ma, Yingxi Li, Xiaoli Dong, Yiming Zhang, Xiaosu Chen, Yue Zhang, Haohan Zou and Yan Wang
    Citation: Journal of Translational Medicine 2024 22:458
  14. Interstitial lung disease (ILD) represents a significant complication of rheumatoid arthritis (RA) that lacks effective treatment options. This study aimed to investigate the intrinsic mechanism by which resve...

    Authors: Nannan Liu, Xuefei Fan, Yubao Shao, Suhuan Chen, Taorong Wang, Tao Yao and Xiaoyu Chen
    Citation: Journal of Translational Medicine 2024 22:457
  15. Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis and hepatocellular carcinoma. Autoimmune hepatitis (AIH) is a liver d...

    Authors: Tamas Pongracz, Maaike Biewenga, Anna Eva Charlotte Stoelinga, Marco René Bladergroen, Simone Nicolardi, Leendert Adrianus Trouw, Manfred Wuhrer, Noortje de Haan and Bart van Hoek
    Citation: Journal of Translational Medicine 2024 22:456
  16. Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with ...

    Authors: Bingtian Dong, Hua Zhang, Yayang Duan, Senbang Yao, Yongjian Chen and Chaoxue Zhang
    Citation: Journal of Translational Medicine 2024 22:455
  17. Glycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma proteins. N-glycosylation occurs on asparagine residues predominantly wi...

    Authors: Kishore Garapati, Anu Jain, Benjamin J. Madden, Dong-Gi Mun, Jyoti Sharma, Rohit Budhraja and Akhilesh Pandey
    Citation: Journal of Translational Medicine 2024 22:454
  18. The lack of distinct biomarkers for pancreatic cancer is a major cause of early-stage detection difficulty. The pancreatic cancer patient group with high metabolic tumor volume (MTV), one of the values measure...

    Authors: Baek Gil Kim, Sung Hwan Lee, Yeonsue Jang, Suki Kang, Chang Moo Kang and Nam Hoon Cho
    Citation: Journal of Translational Medicine 2024 22:453
  19. Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell...

    Authors: Soheil Rahmati, Aysan Moeinafshar and Nima Rezaei
    Citation: Journal of Translational Medicine 2024 22:452
  20. Facioscapulohumeral muscular dystrophy (FSHD) is a high-prevalence autosomal dominant neuromuscular disease characterized by significant clinical and genetic heterogeneity. Genetic diagnosis of FSHD remains a ...

    Authors: Mingtao Huang, Qinxin Zhang, Jiao Jiao, Jianquan Shi, Yiyun Xu, Cuiping Zhang, Ran Zhou, Wenwen Liu, Yixuan Liang, Hao Chen, Yan Wang, Zhengfeng Xu and Ping Hu
    Citation: Journal of Translational Medicine 2024 22:451
  21. Estetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently approved as estrogenic component of a new combined oral contraceptive. E4 ...

    Authors: Francesca Cirillo, Asia Spinelli, Marianna Talia, Domenica Scordamaglia, Maria Francesca Santolla, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Céline Gérard and Rosamaria Lappano
    Citation: Journal of Translational Medicine 2024 22:450
  22. Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)....

    Authors: Jixiang Du, Fuchen Liu, Xihan Liu, Dandan Zhao, Dongdong Wang, Hongsheng Sun, Chuanzhu Yan and Yuying Zhao
    Citation: Journal of Translational Medicine 2024 22:449
  23. The duration of type 2 diabetes mellitus (T2DM) and blood glucose levels have a significant impact on the development of T2DM complications. However, currently known risk factors are not good predictors of the...

    Authors: Mingqian He, Guixue Hou, Mengmeng Liu, Zhaoyi Peng, Hui Guo, Yue Wang, Jing Sui, Hui Liu, Xiaoming Yin, Meng Zhang, Ziyi Chen, Patrick C.N. Rensen, Liang Lin, Yanan Wang and Bingyin Shi
    Citation: Journal of Translational Medicine 2024 22:448
  24. Retinal ischemia/reperfusion (RIR) is implicated in various forms of optic neuropathies, yet effective treatments are lacking. RIR leads to the death of retinal ganglion cells (RGCs) and subsequent vision loss...

    Authors: Jiawen Wu, Daowei zhang, Hongli Liu, Jufeng Li, Ting Li, Jihong Wu and Shenghai Zhang
    Citation: Journal of Translational Medicine 2024 22:447
  25. Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mese...

    Authors: Qian Qin, Zhiyan Shan, Lei Xing, Yutong Jiang, Mengyue Li, Linlin Fan, Xin Zeng, Xinrui Ma, Danyang Zheng, Han Wang, Hui Wang, Hao Liu, Shengjun Liang, Lijie Wu and Shuang Liang
    Citation: Journal of Translational Medicine 2024 22:446
  26. Endometriosis, characterized by the presence of active endometrial-like tissues outside the uterus, causes symptoms like dysmenorrhea and infertility due to the fibrosis of endometrial cells, which involves ex...

    Authors: Mengjie Yang, Hong Jiang, Xinyu Ding, Lu Zhang, Huaying Zhang, Jiahao Chen, Lijun Li, Xinqin He, Zhixiong Huang and Qionghua Chen
    Citation: Journal of Translational Medicine 2024 22:445
  27. Characterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify shared cell–cell interactions (CCIs) within the tumor microenvironment ac...

    Authors: Yelin Zhao, Xinxiu Li, Joseph Loscalzo, Martin Smelik, Oleg Sysoev, Yunzhang Wang, A. K. M. Firoj Mahmud, Dina Mansour Aly and Mikael Benson
    Citation: Journal of Translational Medicine 2024 22:444
  28. The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although neve...

    Authors: Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin III, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang…
    Citation: Journal of Translational Medicine 2024 22:443
  29. Lung cancer is a prevalent malignancy globally, and immunotherapy has revolutionized its treatment. However, resistance to immunotherapy remains a challenge. Abnormal cholinesterase (ChE) activity and choline ...

    Authors: Bijing Xiao, Guanjun Li, Haimiti Gulizeba, Hong Liu, Xiaoxian Sima, Ting Zhou and Yan Huang
    Citation: Journal of Translational Medicine 2024 22:442
  30. Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis a...

    Authors: Juan Jesus Vicente, Kainat Khan, Grant Tillinghast, José L. McFaline-Figueroa, Yasemin Sancak and Nephi Stella
    Citation: Journal of Translational Medicine 2024 22:441
  31. To explore the impact of microRNA 146a (miR-146a) and the underlying mechanisms in profibrotic changes following glaucoma filtering surgery (GFS) in rats and stimulation by transforming growth factor (TGF)-β1 ...

    Authors: Ruiqi Han, Huimin Zhong, Yang Zhang, Huan Yu, Yumeng Zhang, Shouyue Huang, Zijian Yang and Yisheng Zhong
    Citation: Journal of Translational Medicine 2024 22:440
  32. Despite advances in treatment strategies, colorectal cancer (CRC) continues to cause significant morbidity and mortality, with mounting evidence a close link between immune system dysfunctions issued. Interleu...

    Authors: Ehsan Gharib, Leili Rejali, Moein Piroozkhah, Elham Zonoobi, Parinaz Nasri Nasrabadi, Zahra Arabsorkhi, Kaveh Baghdar, Elahe Shams, Amir Sadeghi, Peter J. K. Kuppen, Zahra Salehi and Ehsan Nazemalhosseini-Mojarad
    Citation: Journal of Translational Medicine 2024 22:439
  33. Advanced unresectable gastric cancer (GC) patients were previously treated with chemotherapy alone as the first-line therapy. However, with the Food and Drug Administration’s (FDA) 2022 approval of programmed ...

    Authors: Yifan Liu, Wei Chen, Ruiwen Ruan, Zhimei Zhang, Zhixiong Wang, Tianpei Guan, Qi Lin, Wei Tang, Jun Deng, Zhao Wang and Guanghua Li
    Citation: Journal of Translational Medicine 2024 22:438
  34. Biological-derived hydroxyapatite is widely used as a bone substitute for addressing bone defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory propert...

    Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang and Zhuofan Chen
    Citation: Journal of Translational Medicine 2024 22:437
  35. Subarachnoid hemorrhage (SAH) represents a form of cerebrovascular event characterized by a notable mortality and morbidity rate. Fibroblast growth factor 21 (FGF21), a versatile hormone predominantly synthesi...

    Authors: Yue Ma, Zhiqin Liu, Lele Deng, Jingjing Du, Zenghui Fan, Tian Ma, Jing Xiong, Xue Xiuyun, Naibing Gu, Zhengli Di and Yu Zhang
    Citation: Journal of Translational Medicine 2024 22:436
  36. Cardiometabolic disorders pose significant health risks globally. Metabolic syndrome, characterized by a cluster of potentially reversible metabolic abnormalities, is a known risk factor for these disorders. E...

    Authors: Jacob S. Leiby, Matthew E. Lee, Manu Shivakumar, Eun Kyung Choe and Dokyoon Kim
    Citation: Journal of Translational Medicine 2024 22:434
  37. Doxorubicin (DOX) is a broad-spectrum and highly efficient anticancer agent, but its clinical implication is limited by lethal cardiotoxicity. Growing evidences have shown that alterations in intestinal microb...

    Authors: Chao Huang, Xiaoxia Li, Hanqing Li, Ruolan Chen, Zhaoqing Li, Daisong Li, Xiaojian Xu, Guoliang Zhang, Luning Qin, Bing Li and Xian-Ming Chu
    Citation: Journal of Translational Medicine 2024 22:433
  38. SARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However, whether viro-immunologic parameters or other factors affect immune responses...

    Authors: Giorgio Montesi, Matteo Augello, Jacopo Polvere, Giulia Marchetti, Donata Medaglini and Annalisa Ciabattini
    Citation: Journal of Translational Medicine 2024 22:432
  39. In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling. We investigated the expression of NMTs in nume...

    Authors: Erwan Beauchamp, Jay M. Gamma, Christopher R. Cromwell, Eman W. Moussa, Rony Pain, Morris A. Kostiuk, Claudia Acevedo-Morantes, Aishwarya Iyer, Megan Yap, Krista M. Vincent, Lynne M. Postovit, Olivier Julien, Basil P. Hubbard, John R. Mackey and Luc G. Berthiaume
    Citation: Journal of Translational Medicine 2024 22:431
  40. Previous literature has explored the relationship between chronic atrophic gastritis (CAG) and isolated cancers within the upper gastrointestinal cancers; However, an integrative synthesis across the totality ...

    Authors: Junqiu Li, Jielu Pan, Dinghong Xiao, Nan Shen, Ruiqing Wang, Hongyv Miao, Peimin Pu, Haiyan Zhang, Xiao Yv and Lianjun Xing
    Citation: Journal of Translational Medicine 2024 22:429
  41. Lung adenocarcinoma (LUAD) has been a leading cause of cancer-related mortality worldwide. Early intervention can significantly improve prognosis. DNA methylation could occur in the early stage of tumor. Compr...

    Authors: Junwen Gan, Meng Huang, Weishi Wang, Guining Fu, Mingyuan Hu, Hongcheng Zhong, Xin Ye and Qingdong Cao
    Citation: Journal of Translational Medicine 2024 22:428
  42. Circular RNAs (circRNAs), one of the major contents of exosomes, have been shown to participate in the occurrence and progression of cancers. The role and the diagnostic potential of exosome-transported circRN...

    Authors: Zhenhua Chen, Xinyi Ma, Ziyuan Chen, Wei Chen, Leyi Li, Yichen Lin, Yulin Hu, Yue Shang, Yikai Zhao, Jinxian He, Chengwei Zhou and Xiaodan Meng
    Citation: Journal of Translational Medicine 2024 22:427
  43. Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 ther...

    Authors: Joanna Maria Mierzwicka, Hana Petroková, Leona Rašková Kafková, Petr Kosztyu, Jiří Černý, Milan Kuchař, Miloš Petřík, Kateřina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal Křupka, Jozef Škarda, Milan Raška…
    Citation: Journal of Translational Medicine 2024 22:426
  44. The intricate etiology of autoimmune liver disease (AILD) involves genetic, environmental, and other factors that yet to be completely elucidated. This study comprehensively assessed the causal association bet...

    Authors: Weize Gao, Chong Peng, Zhan Wang, Yongxin Li and Mingjun Liu
    Citation: Journal of Translational Medicine 2024 22:425

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