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  1. Few data are known regarding the molecular features and patterns of growth and presentation which characterize those lung neoplastic lesions presenting as non-solid nodules (NSN).

    Authors: Chandra Bortolotto, Claudio Maglia, Antonio Ciuffreda, Manuela Coretti, Roberta Catania, Filippo Antonacci, Sergio Carnevale, Ivana Sarotto, Roberto Dore, Andrea Riccardo Filippi, Gabriele Chiara, Daniele Regge, Lorenzo Preda, Patrizia Morbini and Giulia Maria Stella

    Citation: Journal of Translational Medicine 2020 18:54

    Content type: Research

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  2. Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin he...

    Authors: Tingting Weng, Pan Wu, Wei Zhang, Yurong Zheng, Qiong Li, Ronghua Jin, Haojiao Chen, Chuangang You, Songxue Guo, Chunmao Han and Xingang Wang

    Citation: Journal of Translational Medicine 2020 18:53

    Content type: Review

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  3. The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metasta...

    Authors: Jennifer Pasquier, Pegah Ghiabi, Lotfi Chouchane, Kais Razzouk, Shahin Rafii and Arash Rafii

    Citation: Journal of Translational Medicine 2020 18:52

    Content type: Review

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  4. Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial member of the zinc finger-homeodomain transcription factor family, originally identified as a binding protein of the lens-spe...

    Authors: Hua-Tao Wu, Hui-Ting Zhong, Guan-Wu Li, Jia-Xin Shen, Qian-Qian Ye, Man-Li Zhang and Jing Liu

    Citation: Journal of Translational Medicine 2020 18:51

    Content type: Review

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  5. Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed ...

    Authors: Andrea Botticelli, Pamela Vernocchi, Federico Marini, Andrea Quagliariello, Bruna Cerbelli, Sofia Reddel, Federica Del Chierico, Francesca Di Pietro, Raffaele Giusti, Alberta Tomassini, Ottavia Giampaoli, Alfredo Miccheli, Ilaria Grazia Zizzari, Marianna Nuti, Lorenza Putignani and Paolo Marchetti

    Citation: Journal of Translational Medicine 2020 18:49

    Content type: Research

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  6. Despite goal-directed hemodynamic therapy, vascular function may deteriorate during surgery for advanced abdominal tumor masses. Fluid administration has been shown to be associated with distinct changes in se...

    Authors: Jennifer Gehlen, Sven Klaschik, Claudia Neumann, Mignon-Denise Keyver-Paik, Alexander Mustea, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft and Tobias Hilbert

    Citation: Journal of Translational Medicine 2020 18:48

    Content type: Research

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  7. Long non-coding RNAs (lncRNAs) have been reported to be prognostic biomarkers in many types of cancer. We aimed to identify a lncRNA signature that can predict the prognosis in patients with esophageal squamou...

    Authors: Nuo-Qing Weng, Jun Chi, Jing Wen, Shi-Juan Mai, Mei-Yin Zhang, Long Huang, Ji Liu, Xian-Zi Yang, Guo-Liang Xu, Jian-Hua Fu and Hui-Yun Wang

    Citation: Journal of Translational Medicine 2020 18:47

    Content type: Research

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  8. Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic evaluation. We aimed to develop and validate a clinical...

    Authors: Menglei Li, Jing Zhang, Yibo Dan, Yefeng Yao, Weixing Dai, Guoxiang Cai, Guang Yang and Tong Tong

    Citation: Journal of Translational Medicine 2020 18:46

    Content type: Research

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  9. Crohn’s disease (CD) is a multifactorial disease characterized by chronic intestinal inflammation. The increased visceral adiposity near the affected intestinal area, of which mesenteric adipose tissue (MAT) i...

    Authors: Francesca Aparecida Ramos da Silva, Lívia Bitencourt Pascoal, Isabella Dotti, Maria de Lourdes Setsuko Ayrizono, Daniel Aguilar, Bruno Lima Rodrigues, Montserrat Arroyes, Elena Ferrer-Picon, Marciane Milanski, Lício Augusto Velloso, João José Fagundes, Azucena Salas and Raquel Franco Leal

    Citation: Journal of Translational Medicine 2020 18:44

    Content type: Research

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  10. Mesenchymal stromal cells (MSCs) have attracted intense interest due to their powerful intrinsic properties of self-regeneration, immunomodulation and multi-potency, as well as being readily available and easy...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu and Fei Mao

    Citation: Journal of Translational Medicine 2020 18:42

    Content type: Review

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  11. Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but...

    Authors: Chen Hao Jiang, Xin Yuan, Jiang Fen Li, Yu Fang Xie, An Zhi Zhang, Xue Li Wang, Lan Yang, Chun Xia Liu, Wei Hua Liang, Li Juan Pang, Hong Zou, Xiao Bin Cui, Xi Hua Shen, Yan Qi, Jin Fang Jiang, Wen Yi Gu…

    Citation: Journal of Translational Medicine 2020 18:40

    Content type: Research

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  12. Human telomerase reverse transcriptase (hTERT) is an antigen that may represent a target for a novel anti-cancer strategy. A pilot, phase I study tested the safety and feasibility of a prime-boost immunization...

    Authors: Luigi Aurisicchio, Arthur Fridman, David Mauro, Rose Sheloditna, Alberto Chiappori, Ansuman Bagchi and Gennaro Ciliberto

    Citation: Journal of Translational Medicine 2020 18:39

    Content type: Research

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  13. Bioresorbable scaffold (BRS) Absorb™ clinical use has been stopped due to higher rate of device thrombosis. Scaffold struts persist longer than 2 years in the vessel wall. Second generation devices are being d...

    Authors: Viktor Kočka, Petr Toušek, Martin Kozel, Andrea Buono, Martin Hajšl, Libor Lisa, Tomáš Buděšínský, Martin Malý and Petr Widimský

    Citation: Journal of Translational Medicine 2020 18:33

    Content type: Research

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  14. There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim w...

    Authors: Cristina Russo, Yvelise Ferro, Samantha Maurotti, Maria Antonietta Salvati, Elisa Mazza, Roberta Pujia, Rosa Terracciano, Giuseppina Maggisano, Rosario Mare, Sandro Giannini, Stefano Romeo, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2020 18:43

    Content type: Research

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  15. Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all cardiovascular diseases have a circadian misalignment usually characterized by changes in metabolites. This stu...

    Authors: Huanjun Wang, Xiaoming Wang, Dongmei Qi, Mengjia Sun, Qingqing Hou, Yunlun Li and Haiqiang Jiang

    Citation: Journal of Translational Medicine 2020 18:38

    Content type: Research

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  16. Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still comple...

    Authors: Réka Rokonay, Apor Veres-Székely, Beáta Szebeni, Domonkos Pap, Rita Lippai, Nóra J. Béres, Gábor Veres, Attila J. Szabó and Ádám Vannay

    Citation: Journal of Translational Medicine 2020 18:36

    Content type: Research

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  17. We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. Howeve...

    Authors: Angela Mauriello, Carmen Manolio, Beatrice Cavalluzzo, Antonio Avallone, Marco Borrelli, Alessandro Morabito, Emanuele Iovine, Angela Chambery, Rosita Russo, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2020 18:34

    Content type: Research

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  18. During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...

    Authors: Haiou Yang, Qianqian Ma, Yu Wang and Zhenhua Tang

    Citation: Journal of Translational Medicine 2020 18:32

    Content type: Review

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  19. Chronic inflammation is a risk factor for head and neck squamous cell carcinoma (HNSCC) and other diseases. Prostanoid receptors are clearly involved in the development of many types of cancer. However, their ...

    Authors: Kiyoshi Misawa, Masato Mima, Yamada Satoshi, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Junya Kita, Yuki Yamaguchi, Shiori Endo, Yuki Misawa and Hiroyuki Mineta

    Citation: Journal of Translational Medicine 2020 18:31

    Content type: Research

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  20. Cardiovascular disease (CVD) is the leading cause of death in the world. Given the role of immune cells in atherosclerosis development and progression, effective methods for characterizing immune cell populati...

    Authors: Yvonne Baumer, Cristhian A. Gutierrez-Huerta, Ankit Saxena, Pradeep K. Dagur, Steven D. Langerman, Kosuke Tamura, Joniqua N. Ceasar, Marcus R. Andrews, Valerie Mitchell, Billy S. Collins, Quan Yu, Heather L. Teague, Martin P. Playford, Christopher K. E. Bleck, Nehal N. Mehta, J. Philip McCoy…

    Citation: Journal of Translational Medicine 2020 18:29

    Content type: Research

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  21. Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice afte...

    Authors: Daniela C. Rosenberger, Uta Binzen, Rolf-Detlef Treede and Wolfgang Greffrath

    Citation: Journal of Translational Medicine 2020 18:28

    Content type: Research

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  22. After publication of abstract S 2‑06 in supplement [1], it was brought to our attention that the second author’s name is spelled incorrectly. Originally the author name has been published as Rajesh Sarma. The ...

    Authors: Choel Kim, Rajesh Sharma and Darren E. Casteel

    Citation: Journal of Translational Medicine 2020 18:27

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:254

  23. Upon publication of the original article [1], it was noticed that Jun Tao’s affiliation information is not complete. The full affiliation information for Jun Tao can be found below and in the complete affiliat...

    Authors: Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin and Jun Tao

    Citation: Journal of Translational Medicine 2020 18:26

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:368

  24. Immune checkpoint inhibitors are effective in some cases of lung adenocarcinoma (LUAD). Whole-exome sequencing has revealed that the tumour mutation burden (TMB) is associated with clinical benefits among pati...

    Authors: Ying Li, Wenbin Jiang, Tianhao Li, Mengyue Li, Xin Li, Zheyang Zhang, Sainan Zhang, Yixin Liu, Wenyuan Zhao, Yunyan Gu, Lishuang Qi, Lu Ao and Zheng Guo

    Citation: Journal of Translational Medicine 2020 18:25

    Content type: Research

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  25. Bone marrow mononuclear cells have been successfully utilized for numerous regenerative purposes. In the current study, patients suffering from erectile dysfunction (ED) unresponsive to phosphodiesterase 5 inh...

    Authors: Mark Bieri, Elias Said, Gabrielle Antonini, Donald Dickerson, Jorge Tuma, Courtney E. Bartlett, Amit N. Patel and Alexander Gershman

    Citation: Journal of Translational Medicine 2020 18:24

    Content type: Research

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  26. Prostate cancer is one of the most common adult malignancies in men, and nearly all patients with metastatic prostate cancer can develop and receive resistance to primary androgen deprivation therapy (ADT), a ...

    Authors: Dawei Wang, Yuan Shao, Xiang Zhang, Guoliang Lu and Boke Liu

    Citation: Journal of Translational Medicine 2020 18:23

    Content type: Research

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  27. A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...

    Authors: Luciana Zaccagni, Natascia Rinaldo, Barbara Bramanti, Jessica Mongillo and Emanuela Gualdi-Russo

    Citation: Journal of Translational Medicine 2020 18:20

    Content type: Research

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  28. The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...

    Authors: Andre Barkhordarian, Gary Demerjian and Francesco Chiappelli

    Citation: Journal of Translational Medicine 2020 18:22

    Content type: Research

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  29. Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used dur...

    Authors: Federica Raggi, Davide Cangelosi, Pamela Becherini, Fabiola Blengio, Martina Morini, Massimo Acquaviva, Maria Luisa Belli, Giuseppe Panizzon, Giuseppe Cervo, Luigi Varesio, Alessandra Eva and Maria Carla Bosco

    Citation: Journal of Translational Medicine 2020 18:21

    Content type: Research

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  30. The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...

    Authors: Mohammad Morshedi, Maryam Saghafi-Asl and Elaheh-Sadat Hosseinifard

    Citation: Journal of Translational Medicine 2020 18:18

    Content type: Research

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  31. Recent studies have shown that selenium-binding protein 1 (SELENBP1) is significantly down-regulated in a variety of solid tumors. Nevertheless, the clinical relevance of SELENBP1 in human bladder cancer has n...

    Authors: Yulei Wang, Wenzhen Zhu, Xiaoqing Chen, Guangnan Wei, Guosong Jiang and Guochun Zhang

    Citation: Journal of Translational Medicine 2020 18:17

    Content type: Research

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  32. Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorp...

    Authors: Mahsa Mahmoudi-Nezhad, Mahdieh Abbasalizad Farhangi and Houman Kahroba

    Citation: Journal of Translational Medicine 2020 18:16

    Content type: Research

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  33. Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...

    Authors: M.-C. Laï, M. Brian and M.-F. Mamzer

    Citation: Journal of Translational Medicine 2020 18:14

    Content type: Research

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  34. Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune checkpoint inhibitors has provided promising results, m...

    Authors: Trude G. Simonsen, Jon-Vidar Gaustad and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2020 18:13

    Content type: Research

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  35. Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal ste...

    Authors: Fang-Zhu Wan, Kai-Hua Chen, Yong-Chu Sun, Xi-Chan Chen, Ren-Ba Liang, Li Chen and Xiao-Dong Zhu

    Citation: Journal of Translational Medicine 2020 18:12

    Content type: Research

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  36. Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic param...

    Authors: Manuel Weber, Falk Wehrhan, Christoph Baran, Abbas Agaimy, Maike Büttner-Herold, Hatice Öztürk, Kristina Neubauer, Claudia Wickenhauser, Marco Kesting and Jutta Ries

    Citation: Journal of Translational Medicine 2020 18:11

    Content type: Research

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  37. Predicting the clinical course of prostate cancer is challenging due to the wide biological spectrum of the disease. The objective of our study was to identify prostate cancer prognostic markers in patients ‘s...

    Authors: Michael A. Kiebish, Jennifer Cullen, Prachi Mishra, Amina Ali, Eric Milliman, Leonardo O. Rodrigues, Emily Y. Chen, Vladimir Tolstikov, Lixia Zhang, Kiki Panagopoulos, Punit Shah, Yongmei Chen, Gyorgy Petrovics, Inger L. Rosner, Isabell A. Sesterhenn, David G. McLeod…

    Citation: Journal of Translational Medicine 2020 18:10

    Content type: Research

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  38. The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/enceph...

    Authors: Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel and Frank Pessler

    Citation: Journal of Translational Medicine 2020 18:9

    Content type: Research

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  39. Serum protein glycosylation is an area of investigation in inflammatory arthritic disorders such as rheumatoid arthritis (RA). Indeed, some studies highlighted abnormalities of protein glycosylation in RA. Con...

    Authors: Federica Ciregia, Dominique Baiwir, Gaël Cobraiville, Thibaut Dewael, Gabriel Mazzucchelli, Valérie Badot, Silvana Di Romana, Paschalis Sidiras, Tatiana Sokolova, Patrick Durez, Michel G. Malaise and Dominique de Seny

    Citation: Journal of Translational Medicine 2020 18:8

    Content type: Research

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  40. Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we system...

    Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:7

    Content type: Review

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  41. The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...

    Authors: Irene Consuegra Fernández, Isabel García Merino and María Ángeles Muñoz-Fernández

    Citation: Journal of Translational Medicine 2020 18:6

    Content type: Research

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  42. Sepsis remains a major challenge in intensive care units, causing unacceptably high mortality rates due to the lack of rapid diagnostic tools with sufficient sensitivity. Therefore, there is an urgent need to ...

    Authors: Pei Chen, Shuo Li, Wenyuan Li, Jie Ren, Fengzhu Sun, Rui Liu and Xianghong Jasmine Zhou

    Citation: Journal of Translational Medicine 2020 18:5

    Content type: Research

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  43. Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; how...

    Authors: Rosa María Escorihuela, Lluís Capdevila, Juan Ramos Castro, María Cleofé Zaragozà, Sara Maurel, José Alegre and Jesús Castro-Marrero

    Citation: Journal of Translational Medicine 2020 18:4

    Content type: Research

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  44. The prevalence of autoimmune hepatitis (AIH) is increasing, and its early clinical diagnosis is difficult. The pathogenesis of AIH remains unclear, and AIH-related studies are largely limited because of lack o...

    Authors: Han Wang, Wei Yan, Zuohua Feng, Yuan Gao, Liu Zhang, Xinxia Feng and Dean Tian

    Citation: Journal of Translational Medicine 2020 18:3

    Content type: Research

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  45. Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive ...

    Authors: Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro and Sergio Rutella

    Citation: Journal of Translational Medicine 2020 18:2

    Content type: Research

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  46. The present review aimed to discuss contemporary scientific literature involving differences between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in their primary site and TME i...

    Authors: Bernardo Cacho-Díaz, Donovan R. García-Botello, Talia Wegman-Ostrosky, Gervith Reyes-Soto, Elizabeth Ortiz-Sánchez and Luis Alonso Herrera-Montalvo

    Citation: Journal of Translational Medicine 2020 18:1

    Content type: Review

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  47. Lung cancer is the leading cause of cancer-related death worldwide, and the timely and serial assessment of low-dose computed tomography (LDCT) in high-risk populations remains a challenge. Furthermore, testin...

    Authors: Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao and Jie He

    Citation: Journal of Translational Medicine 2019 17:430

    Content type: Research

    Published on:

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