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  1. 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been stud...

    Authors: Min Liu, Moyun Li, Yu Zhou, Qian Zhou and Yugang Jiang

    Citation: Journal of Translational Medicine 2020 18:166

    Content type: Research

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  2. Malignant serous effusion (MSE) denotes a manifestation of metastatic disease with typical high concentrations of both cancer and immune cells, making them an ideal resource for in vitro cytologic studies. Hen...

    Authors: Cheng-Guang Wu, Francesca Chiovaro, Alessandra Curioni-Fontecedro, Ruben Casanova and Alex Soltermann

    Citation: Journal of Translational Medicine 2020 18:163

    Content type: Research

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  3. Studies on the early 2000s documented increasing attrition rates and duration of clinical trials, leading to a representation of a “productivity crisis” in pharmaceutical research and development (R&D). In thi...

    Authors: Fabio Pammolli, Lorenzo Righetto, Sergio Abrignani, Luca Pani, Pier Giuseppe Pelicci and Emanuele Rabosio

    Citation: Journal of Translational Medicine 2020 18:162

    Content type: Research

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  4. Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal dege...

    Authors: Magda M. Santana, Susana Paixão, Janete Cunha-Santos, Teresa Pereira Silva, Allyson Trevino-Garcia, Laetitia S. Gaspar, Clévio Nóbrega, Rui Jorge Nobre, Cláudia Cavadas, Hagar Greif and Luís Pereira de Almeida

    Citation: Journal of Translational Medicine 2020 18:161

    Content type: Research

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  5. Prostate cancer (PCa) is one of the most prevalent cancers that occur in men worldwide. Autophagy-related genes (ARGs) may play an essential role in multiple biological processes of prostate cancer. However, A...

    Authors: Daixing Hu, Li Jiang, Shengjun Luo, Xin Zhao, Hao Hu, Guozhi Zhao and Wei Tang

    Citation: Journal of Translational Medicine 2020 18:160

    Content type: Research

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  6. HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used in the treatment of lymphocyte-derived malignancies, but their mechanisms of action remain poorly understood. Here ...

    Authors: Tobias S. Iveland, Lars Hagen, Animesh Sharma, Mirta M. L. Sousa, Antonio Sarno, Kristian Lied Wollen, Nina Beate Liabakk and Geir Slupphaug

    Citation: Journal of Translational Medicine 2020 18:159

    Content type: Research

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  7. The formal risk assessment is essential in the management of acute coronary syndrome (ACS). In this study, we develop a risk model for the prediction of 3-year mortality for Chinese ACS patients with machine l...

    Authors: Yi-ming Li, Zhuo-lun Li, Fei Chen, Qi Liu, Yong Peng and Mao Chen

    Citation: Journal of Translational Medicine 2020 18:157

    Content type: Research

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  8. Sphingosine-1-phosphate (S1P) is a signaling phospholipid involved in pathophysiologic progression of acute respiratory distress syndrome (ARDS) through its roles in endothelial barrier function and immune mod...

    Authors: Jiangnan Zhao, Yan Tan, Li Wang, Xin Su and Yi Shi

    Citation: Journal of Translational Medicine 2020 18:156

    Content type: Research

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  9. The statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol ...

    Authors: Shabnam Tahamtan, Farinaz Shirban, Mohammad Bagherniya, Thomas P. Johnston and Amirhossein Sahebkar

    Citation: Journal of Translational Medicine 2020 18:155

    Content type: Review

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  10. Since the first case of a coronavirus disease 2019 (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Southwest China. The aim of this study ...

    Authors: Xiaoming Li, Wenbing Zeng, Xiang Li, Haonan Chen, Linping Shi, Xinghui Li, Hongnian Xiang, Yang Cao, Hui Chen, Chen Liu and Jian Wang

    Citation: Journal of Translational Medicine 2020 18:154

    Content type: Research

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  11. The selection of treatment for a patient with breast cancer largely relies on the cancer subtype. However, this process is complicated by changes in tumor biology at relapse. Smoking has been identified as a r...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Hisakazu Fujita, Masatsune Shibutani, Tsutomu Takashima, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2020 18:153

    Content type: Research

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  12. Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (l...

    Authors: Hossein Mozdarani, Vahid Ezzatizadeh and Roghayeh Rahbar Parvaneh

    Citation: Journal of Translational Medicine 2020 18:152

    Content type: Review

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  13. Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) as a first-line therapy in diabetic hypertensive patients and for secondary prevention in patien...

    Authors: Yue Zhang, Xiaosong Ding, Bing Hua, Qingbo Liu, Hui Chen, Xue-Qiao Zhao, Weiping Li and Hongwei Li

    Citation: Journal of Translational Medicine 2020 18:150

    Content type: Research

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  14. Given that abnormal autophagy is involved in the pathogenesis of cancers, we sought to explore the potential value of autophagy-associated genes in lung adenocarcinoma (LUAD).

    Authors: Xiaofei Wang, Shuang Yao, Zengtuan Xiao, Jialin Gong, Zuo Liu, Baoai Han and Zhenfa Zhang

    Citation: Journal of Translational Medicine 2020 18:149

    Content type: Research

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  15. Adoptive transfer of virus-specific T cells (VSTs) represents a prophylactic and curative approach for opportunistic viral infections and reactivations after transplantation. However, inadequate frequencies of...

    Authors: Nele Carolin Heinemann, Sabine Tischer-Zimmermann, Torge Christian Wittke, Julian Eigendorf, Arno Kerling, Theodor Framke, Anette Melk, Hans-Gert Heuft, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper

    Citation: Journal of Translational Medicine 2020 18:148

    Content type: Research

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  16. Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation. Complement activation and reg...

    Authors: Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Journal of Translational Medicine 2020 18:147

    Content type: Research

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  17. Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage is usually not recognized and diagnosed. It is necessary to esta...

    Authors: Xia Ma, Yanping Wu, Ling Zhang, Weilan Yuan, Li Yan, Sha Fan, Yunzhi Lian, Xia Zhu, Junhui Gao, Jiangman Zhao, Ping Zhang, Hui Tang and Weihua Jia

    Citation: Journal of Translational Medicine 2020 18:146

    Content type: Research

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  18. Bladder cancer is the most common cancer in the urinary system and the fourth most common cancer in males. This study aimed to examine differences in the survival of bladder cancer patients of different ethnic...

    Authors: Wei Fang, Zhi-Yan Yang, Ting-Yu Chen, Xian-Feng Shen and Chao Zhang

    Citation: Journal of Translational Medicine 2020 18:145

    Content type: Research

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  19. As the most common form of lymphoma, diffuse large B-cell lymphoma (DLBCL) is a clinical highly heterogeneous disease with variability in therapeutic outcomes and biological features. It is a challenge to iden...

    Authors: Jinglei Hu, Jing Xu, Muqiao Yu, Yongchao Gao, Rong Liu, Honghao Zhou and Wei Zhang

    Citation: Journal of Translational Medicine 2020 18:144

    Content type: Research

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  20. Hepatitis B virus (HBV) remains a major cause of chronic hepatitis and hepatocellular carcinoma, and miRNAs play important roles in HBV pathogenesis. Our previous study has shown that miR-328-3p is upregulated...

    Authors: Xiaoyu Fu, Yi Ouyang, Juan Mo, Ronghua Li, Lei Fu and Shifang Peng

    Citation: Journal of Translational Medicine 2020 18:143

    Content type: Research

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  21. To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas.

    Authors: Roberto Roklicer, Nemanja Lakicevic, Valdemar Stajer, Tatjana Trivic, Antonino Bianco, Diba Mani, Zoran Milosevic, Nebojsa Maksimovic, Antonio Paoli and Patrik Drid

    Citation: Journal of Translational Medicine 2020 18:142

    Content type: Research

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  22. Smoke inhalation injury increases overall burn mortality by up to 20 times. Current therapy remains supportive with a failure to identify an optimal or targeted treatment protocol for smoke inhalation injury. ...

    Authors: Alexandra Mercel, Nick D. Tsihlis, Rob Maile and Melina R. Kibbe

    Citation: Journal of Translational Medicine 2020 18:141

    Content type: Review

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  23. Cancer Immunotherapy has recently emerged as a promising and effective modality to treat different malignancies. Antigenic profiling of cancer tissues and determination of any pre-existing immune responses to ...

    Authors: Afsheen Raza, Maysaloun Merhi, Varghese Philipose Inchakalody, Roopesh Krishnankutty, Allan Relecom, Shahab Uddin and Said Dermime

    Citation: Journal of Translational Medicine 2020 18:140

    Content type: Review

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  24. Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Due to its high morbidity and mortality rates, it is urgent to find a molecular target that contributes to esophageal c...

    Authors: Rui Cai, Ping Wang, Xin Zhao, Xiansheng Lu, Ruxia Deng, Xiaoyu Wang, Zhaoji Su, Chang Hong and Jie Lin

    Citation: Journal of Translational Medicine 2020 18:139

    Content type: Research

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  25. The skin is the largest organ of the human body. Upon injury, the skin triggers a sequence of signaling pathways that induce epithelial proliferation, migration, and ultimately, the re-establishment of the epi...

    Authors: Carlos H. V. Nascimento-Filho, Ericka J. D. Silveira, Eny M. Goloni-Bertollo, Lelia Batista de Souza, Cristiane H. Squarize and Rogerio M. Castilho

    Citation: Journal of Translational Medicine 2020 18:138

    Content type: Research

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  26. Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein ki...

    Authors: Fares Qeadan, Pranshu Bansal, Joshua A. Hanson and Ellen J. Beswick

    Citation: Journal of Translational Medicine 2020 18:137

    Content type: Research

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  27. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanism...

    Authors: Emilie Bequignon, David Mangin, Justine Bécaud, Jennifer Pasquier, Christelle Angely, Mathieu Bottier, Estelle Escudier, Daniel Isabey, Marcel Filoche, Bruno Louis, Jean-François Papon and André Coste

    Citation: Journal of Translational Medicine 2020 18:136

    Content type: Research

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  28. Peroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is...

    Authors: Leslie R. Morse, Nguyen Nguyen, Yan Xu, Prakash Jha and Ricardo A. Battaglino

    Citation: Journal of Translational Medicine 2020 18:135

    Content type: Research

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  29. The most appropriate management for patients with stage IV ovarian cancer remains unclear. Our objective was to understand the main determinants associated with survival and to discuss best surgical management.

    Authors: Yohann Dabi, Cyrille Huchon, Lobna Ouldamer, Sofiane Bendifallah, Pierre Collinet, Alexandre Bricou, Emile Daraï, Marcos Ballester, Vincent Lavoue, Bassam Haddad and Cyril Touboul

    Citation: Journal of Translational Medicine 2020 18:134

    Content type: Research

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  30. It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are assoc...

    Authors: Zhimin Ma, Chaonan Xu, Xiaoping Kang, Shan Zhang, Haibin Li, Lixin Tao, Deqiang Zheng, Xiuhua Guo and Xinghua Yang

    Citation: Journal of Translational Medicine 2020 18:133

    Content type: Research

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  31. Sequencing of miRNAs isolated from exosomes has great potential to identify novel disease biomarkers, but exosomes have low amount of RNA, hindering adequate analysis and quantification. Here, we have assessed...

    Authors: Dolores Olivares, Javier Perez-Hernandez, Daniel Perez-Gil, Felipe J. Chaves, Josep Redon and Raquel Cortes

    Citation: Journal of Translational Medicine 2020 18:132

    Content type: Methodology

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  32. Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in ...

    Authors: Yang Zhou, Ying Zhang, Jinming Han, Mengge Yang, Jie Zhu and Tao Jin

    Citation: Journal of Translational Medicine 2020 18:131

    Content type: Review

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  33. Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. H...

    Authors: Fengping Liu, Nan Zhang, Peng Jiang, Qixiao Zhai, Chen Li, Deshui Yu, Yan Wu, Yuwei Zhang, Longxian Lv, Xinyu Xu and Ninghan Feng

    Citation: Journal of Translational Medicine 2020 18:130

    Content type: Research

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  34. Identifying the early-stage colon adenocarcinoma (ECA) patients who have lower risk cancer vs. the higher risk cancer could improve disease prognosis. Our study aimed to explore whether the glandular morpholog...

    Authors: Meng-Yao Ji, Lei Yuan, Shi-Min Lu, Meng-Ting Gao, Zhi Zeng, Na Zhan, Yi-Juan Ding, Zheng-Ru Liu, Ping-Xiao Huang, Cheng Lu and Wei-Guo Dong

    Citation: Journal of Translational Medicine 2020 18:129

    Content type: Research

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  35. The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. The aim of our study was to examine epidemiological trends in incidence and incide...

    Authors: Jiakun Wang, Aoxiao He, Qian Feng, Ping Hou, Junjun Wu, Zhihao Huang, Zhouqing Xiao, Chi Sun, Wenjun Liao and Linquan Wu

    Citation: Journal of Translational Medicine 2020 18:128

    Content type: Research

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  36. The role of the human microbiome in human health and disease has been studied in various body sites. However, compared to the gut microbiome, where most of the research focus is, the salivary microbiome still ...

    Authors: Selvasankar Murugesan, Sara Fahad Al Ahmad, Parul Singh, Marwa Saadaoui, Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:127

    Content type: Research

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  37. Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular carcinoma (HCC). This study was intended to identify the function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role in ...

    Authors: Yuan Chi, Zheng Gong, He Xin, Ziwen Wang and Zhaoyu Liu

    Citation: Journal of Translational Medicine 2020 18:126

    Content type: Research

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  38. Monocytes and toll-like receptors (TLR) have been found in the inflammatory infiltrate of muscle biopsies in patients with idiopathic inflammatory myopathies (IIM), suggesting an important role of these cells ...

    Authors: Jiram Torres-Ruiz, Daniel Alberto Carrillo-Vazquez, Diana Marcela Padilla-Ortiz, Ricardo Vazquez-Rodriguez, Carlos Nuñez-Alvarez, Guillermo Juarez-Vega and Diana Gomez-Martin

    Citation: Journal of Translational Medicine 2020 18:125

    Content type: Research

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  39. Research has associated human epidermal growth factor receptor (HER2) with glucose and lipid metabolism. However, the association between circulating HER2 levels and coronary artery disease (CAD) remains to be...

    Authors: Wen Jian, Chun-Mei Wei, Jia-Hui Guan, Chang-Hua Mo, Yu-Tao Xu, Wen-Bo Zheng, Lang Li and Chun Gui

    Citation: Journal of Translational Medicine 2020 18:124

    Content type: Research

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  40. Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary met...

    Authors: Thomas Olsen, Bente Øvrebø, Nadia Haj-Yasein, Sindre Lee, Karianne Svendsen, Marit Hjorth, Nasser E. Bastani, Frode Norheim, Christian A. Drevon, Helga Refsum and Kathrine J. Vinknes

    Citation: Journal of Translational Medicine 2020 18:122

    Content type: Research

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  41. PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify re...

    Authors: Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto…

    Citation: Journal of Translational Medicine 2020 18:121

    Content type: Research

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  42. The performance of previously published glomerular filtration rate (GFR) estimation equations degrades when directly used in Chinese population. We incorporated more independent variables and using complicated...

    Authors: Ningshan Li, Hui Huang, Han-Zhu Qian, Peijia Liu, Hui Lu and Xun Liu

    Citation: Journal of Translational Medicine 2020 18:120

    Content type: Research

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  43. Prostate cancer (PCa) is a common malignant tumor with increasing incidence and high heterogeneity among males worldwide. In the era of big data and artificial intelligence, the paradigm of biomarker discovery...

    Authors: Yuxin Lin, Xiaojun Zhao, Zhijun Miao, Zhixin Ling, Xuedong Wei, Jinxian Pu, Jianquan Hou and Bairong Shen

    Citation: Journal of Translational Medicine 2020 18:119

    Content type: Review

    Published on:

  44. Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer. The prognostic signature could be reliable to stratify LUAD patients according to risk, which helps the management of the systematic trea...

    Authors: Dina Guo, Mian Wang, Zhihong Shen and Jiaona Zhu

    Citation: Journal of Translational Medicine 2020 18:123

    Content type: Research

    Published on:

  45. Lupus nephritis is one of the most common and severe complications of systemic lupus erythematosus, of which poor prognosis is indicated by aggravated renal hypoxia and tubulointerstitial fibrosis. Cell adhesi...

    Authors: Liwen Zhang, Sheng Chen, Yan Liu, Xueqin Xu, Qianying Zhang, Shuxin Shao, Weiming Wang and Xiao Li

    Citation: Journal of Translational Medicine 2020 18:116

    Content type: Research

    Published on:

  46. The global burden of hepatitis B virus (HBV) infection in terms of morbidity and mortality is immense. Novel treatments that can induce a protective immune response are urgently needed to effectively control t...

    Authors: Yunlong Hu, Li Tang, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang and Guangyi Jin

    Citation: Journal of Translational Medicine 2020 18:112

    Content type: Research

    Published on:

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