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  1. DNA electroporation has been demonstrated in preclinical models to be a promising strategy to improve cancer immunity, especially when combined with other genetic vaccines in heterologous prime-boost protocols...

    Authors: Claudia Marcela Diaz, Alberto Chiappori, Luigi Aurisicchio, Ansuman Bagchi, Jason Clark, Sheri Dubey, Arthur Fridman, Jesus C Fabregas, John Marshall, Elisa Scarselli, Nicola La Monica, Gennaro Ciliberto and Alberto J Montero
    Citation: Journal of Translational Medicine 2013 11:62
  2. Tumor-derived cytokines and their receptors usually take important roles in the disease progression and prognosis of cancer patients. In this survey, we aimed to detect the expression levels of MIF and CXCR4 i...

    Authors: Lin Zhang, Shu-Biao Ye, Gang Ma, Xiao-Feng Tang, Shi-Ping Chen, Jia He, Wan-Li Liu, Dan Xie, Yi-Xin Zeng and Jiang Li
    Citation: Journal of Translational Medicine 2013 11:60
  3. Protein tyrosine kinase 6 (PTK6), also known as breast tumor kinase (Brk), was a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. The deregulated expression of PTK6 was o...

    Authors: Xue-Kui Liu, Xin-Rui Zhang, Qian Zhong, Man-Zhi Li, Zhi-Min Liu, Zhi-Rui Lin, Di Wu and Mu-Sheng Zeng
    Citation: Journal of Translational Medicine 2013 11:59
  4. According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown.

    Authors: Miao-zhen Qiu, Mu-yan Cai, Dong-sheng Zhang, Zhi-qiang Wang, De-shen Wang, Yu-hong Li and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:58
  5. In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the invasiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression prof...

    Authors: Daya Luo, James M Wilson, Nikki Harvel, Jimei Liu, Lirong Pei, Shuang Huang, LesleyAnn Hawthorn and Huidong Shi
    Citation: Journal of Translational Medicine 2013 11:57
  6. Heart failure is one of the key causes of morbidity and mortality world-wide. The recent findings that regeneration is possible in the heart have made stem cell therapeutics the Holy Grail of modern cardiovasc...

    Authors: Leo Bockeria, Vladimir Bogin, Olga Bockeria, Tatyana Le, Bagrat Alekyan, Erik J Woods, Amalia A Brown, Thomas E Ichim and Amit N Patel
    Citation: Journal of Translational Medicine 2013 11:56
  7. Recent investigations of the tumor microenvironment have shown that many tumors are infiltrated by inflammatory and lymphocytic cells. Increasing evidence suggests that the number, type and location of these t...

    Authors: Paolo A Ascierto, Mariaelena Capone, Walter J Urba, Carlo B Bifulco, Gerardo Botti, Alessandro Lugli, Francesco M Marincola, Gennaro Ciliberto, Jérôme Galon and Bernard A Fox
    Citation: Journal of Translational Medicine 2013 11:54
  8. Age-related macular degeneration (AMD) is the leading cause of blindness in people over age 55 in the U.S. and the developed world. This condition leads to the progressive impairment of central visual acuity. ...

    Authors: Heather Melville, Matthew Carpiniello, Kia Hollis, Andrew Staffaroni and Nady Golestaneh
    Citation: Journal of Translational Medicine 2013 11:53
  9. HIV-infected patients display an increased and early incidence of osteopenia/osteoporosis. We investigated whether bone metabolism disorders in HIV-infected patients are related to immune hyperactivation and p...

    Authors: Lidia Gazzola, Giusi Maria Bellistri, Camilla Tincati, Valentina Ierardi, Alessia Savoldi, Angelo Del Sole, Luca Tagliabue, Antonella d’Arminio Monforte and Giulia Marchetti
    Citation: Journal of Translational Medicine 2013 11:51
  10. Wnt signaling in the colon cancer tumor microenvironment (TME) may affect cancer biologic properties including invasion and metastatic dissemination. Prior reports have suggested that the expression of select ...

    Authors: Kestutis Planutis, Marina Planutiene, Anthony V Nguyen, Mary Pat Moyer and Randall F Holcombe
    Citation: Journal of Translational Medicine 2013 11:50
  11. This pilot study investigated the association between heat shock protein 70 (HSP70) and anti-HSP70 antibodies as well as their changes and rhythm outcome after atrial fibrillation (AF) catheter ablation.

    Authors: Jelena Kornej, Claudia Reinhardt, Jedrzej Kosiuk, Arash Arya, Gerhard Hindricks, Volker Adams, Daniela Husser and Andreas Bollmann
    Citation: Journal of Translational Medicine 2013 11:49
  12. HIV-1 infection generates numerous abnormalities in the B cell compartment which can be partly reversed by antiretroviral therapy. Our aim was to evaluate the effects that re-exposure to HIV antigens might hav...

    Authors: Anuska Llano, Jorge Carrillo, Beatriz Mothe, Lidia Ruiz, Silvia Marfil, Elisabet García, Eloísa Yuste, Víctor Sánchez, Bonaventura Clotet, Julià Blanco and Christian Brander
    Citation: Journal of Translational Medicine 2013 11:48
  13. An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immu...

    Authors: Ping Huang, Shouyi Yu, Changyou Wu and Lijun Liang
    Citation: Journal of Translational Medicine 2013 11:47
  14. Imatinib mesylate is an effective treatment for metastatic gastrointestinal stromal tumor (GIST). However, most patients eventually develop resistance and there are few other treatment options. Immunotherapy u...

    Authors: Steven C Katz, Rachel A Burga, Seema Naheed, Lauren A Licata, Mitchell Thorn, Doreen Osgood, Cang T Nguyen, N Joseph Espat, Jonathan A Fletcher and Richard P Junghans
    Citation: Journal of Translational Medicine 2013 11:46
  15. The sixth leading class of cancer worldwide is head and neck cancer, which typically arise within the squamous epithelium of the oral mucosa. Human head and neck squamous cell carcinoma (HNSCC) is known to be ...

    Authors: Bradford Hall, Hideyuki Nakashima, Zhi-Jun Sun, Yuki Sato, Yansong Bian, Syed R Husain, Raj K Puri and Ashok B Kulkarni
    Citation: Journal of Translational Medicine 2013 11:45
  16. Several peripheral proteins that might be useful for detecting the presence of ectopic pregnancy (EP) have been evaluated, but none have been proven entirely useful in the clinic. We investigated the presence ...

    Authors: Shien Zou, Xin Li, Yi Feng, Shan Sun, Jin Li, Emil Egecioglu, Håkan Billig and Ruijin Shao
    Citation: Journal of Translational Medicine 2013 11:44
  17. Besides being a preferential site of early metastasis, the sentinel lymph node (SLN) is also a privileged site of T-cell priming, and may thus be an appropriate target for investigating cell types involved in ...

    Authors: Anita Mohos, Tímea Sebestyén, Gabriella Liszkay, Vanda Plótár, Szabolcs Horváth, István Gaudi and Andrea Ladányi
    Citation: Journal of Translational Medicine 2013 11:43
  18. Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth o...

    Authors: Prabha B Mishra, Aurelio S Lobo, Kalpana S Joshi, Maggie J Rathos, Gopinath A Kumar and Muralidhara Padigaru
    Citation: Journal of Translational Medicine 2013 11:42
  19. Cryoablation is one of the local therapies for hepatocellular carcinoma (HCC), but its safety and effect has not been studied in patients with Child class A or B and Barcelona Clinic Liver Cancer (BCLC) stage ...

    Authors: Yong-Ping Yang, Jian-Hui Qu, Xiu-Juan Chang, Yin-Ying Lu, Wen-Lin Bai, Zheng Dong, Hong Wang, Lin-Jing An, Zhong-Xian Xu, Chun-Ping Wang, Zhen Zeng and Ke-Qin Hu
    Citation: Journal of Translational Medicine 2013 11:41
  20. Left ventricular (LV) remodeling following large transmural myocardial infarction (MI) remains a pivotal clinical issue despite the advance of medical treatment over the past few decades. Identification of new...

    Authors: Yue-Feng Chen, Nathan Y Weltman, Xiang Li, Steven Youmans, David Krause and Anthony Martin Gerdes
    Citation: Journal of Translational Medicine 2013 11:40
  21. Experimental clinical stem cell therapy has been used for more than a decade to alleviate the adverse aftermath of acute myocardial infarction (aMI). The post-infarcted myocardial microenvironment is character...

    Authors: Ewa Przybyt, Guido Krenning, Marja GL Brinker and Martin C Harmsen
    Citation: Journal of Translational Medicine 2013 11:39
  22. The effect of the addition of fotemustine and/or interferon (IFN) to standard therapy with dacarbazine alone in patients with advanced malignant melanoma was investigated in a multicenter, randomized 2x2 facto...

    Authors: Antonio Daponte, Simona Signoriello, Luigi Maiorino, Bruno Massidda, Ester Simeone, Antonio Maria Grimaldi, Corrado Caracò, Giuseppe Palmieri, Antonio Cossu, Gerardo Botti, Antonella Petrillo, Secondo Lastoria, Ernesta Cavalcanti, Pasquale Aprea, Nicola Mozzillo, Ciro Gallo…
    Citation: Journal of Translational Medicine 2013 11:38
  23. Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effect...

    Authors: Saskia JAM Santegoets, Annelies W Turksma, Megan M Suhoski, Anita GM Stam, Steve M Albelda, Erik Hooijberg, Rik J Scheper, Alfons JM van den Eertwegh, Winald R Gerritsen, Daniel J Powell Jr, Carl H June and Tanja D de Gruijl
    Citation: Journal of Translational Medicine 2013 11:37
  24. TOP2A encodes for topoisomerase IIα, a nuclear enzyme that controls DNA topological structure and cell cycle progression. This enzyme is a marker of cell proliferation in normal and neoplastic tissues; however, l...

    Authors: Marina França de Resende, Samantha Vieira, Ludmilla Thomé Domingos Chinen, Francesco Chiappelli, Francisco Paulo da Fonseca, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Ivan Neves, Simone Pagotty, Peter A Pellionisz, Andre Barkhordarian, Xenia Brant and Rafael Malagoli Rocha
    Citation: Journal of Translational Medicine 2013 11:36
  25. Myeloid-derived suppressor cells (MDSCs) are one of the major components of the immune-suppressive network, play key roles in tumor progression and limit therapeutic responses. Recently, we reported that tumor...

    Authors: Archana Thakur, Dana Schalk, Elyse Tomaszewski, Sri Vidya Kondadasula, Hiroshi Yano, Fazlul H Sarkar and Lawrence G Lum
    Citation: Journal of Translational Medicine 2013 11:35
  26. Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Authors: Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr
    Citation: Journal of Translational Medicine 2013 11:34
  27. Hirsutanol A is a novel sesquiterpene compound purified from fungus Chondrostereum sp. in Sarcophyton tortuosum. Our previous studies had demonstrated that hirsutanol A exhibited potent cytotoxic effect on many k...

    Authors: Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li and Xiao-Feng Zhu
    Citation: Journal of Translational Medicine 2013 11:32
  28. MicroRNAs (miRNAs) are small (19-22-nt) single-stranded noncoding RNA molecules whose deregulation of expression can contribute to human disease including the multistep processes of carcinogenesis in human. Ci...

    Authors: Hussein Fayyad-Kazan, Nizar Bitar, Mehdi Najar, Philippe Lewalle, Mohammad Fayyad-Kazan, Rabih Badran, Eva Hamade, Ahmad Daher, Nader Hussein, Rim ELDirani, Fadwa Berri, Luc Vanhamme, Arsène Burny, Philippe Martiat, Redouane Rouas and Bassam Badran
    Citation: Journal of Translational Medicine 2013 11:31
  29. Natural Killer (NK) cells are known to reject several experimental murine tumors, but their antineoplastic activity in humans is not generally agreed upon, as exemplified by an interesting correspondence recen...

    Authors: Doriana Fruci, Elisa Lo Monaco, Loredana Cifaldi, Franco Locatelli, Elisa Tremante, Maria Benevolo and Patrizio Giacomini
    Citation: Journal of Translational Medicine 2013 11:30
  30. Colorectal carcinomas spread easily to nearby tissues around the colon or rectum, and display strong potential for invasion and metastasis. CSE1L, the chromosome segregation 1-like protein, is implicated in ca...

    Authors: Cheng-Jeng Tai, Tzu-Cheng Su, Ming-Chung Jiang, Hung-Chang Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Ching-Fong Liao, Ying-Chun Chen, Shu-Hui Lin, Li-Tzu Li, Ko-Hung Shen, Chung-Min Yeh, Kun-Tu Yeh, Ching-Hsiao Lee, Hsin-Yi Shih and Chun-Chao Chang
    Citation: Journal of Translational Medicine 2013 11:29

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:315

  31. The early peritoneal invasion of epithelial ovarian cancer (EOC) by tumoral aggregates presents in ascites is a major concern. The role of the microenvironment seems to be important in this process but the lac...

    Authors: Cyril Touboul, Raphael Lis, Halema Al Farsi, Christophe M Raynaud, Mohamed Warfa, Hamda Althawadi, Eliane Mery, Massoud Mirshahi and Arash Rafii
    Citation: Journal of Translational Medicine 2013 11:28
  32. The discovery of mesenchymal stem cells (MSCs) or MSC-like cells in cartilage tissue does not tie in well with the established view that MSCs derive from a perivascular niche. The presence of MSCs may raise co...

    Authors: Karin Benz, Claudia Stippich, Christian Freudigmann, Juergen A Mollenhauer and Wilhelm K Aicher
    Citation: Journal of Translational Medicine 2013 11:27
  33. Linker for activation of T cells (LAT), a transmembrane adaptor protein, plays a role in T cell and mast cell function, while it remains unclear how histone modifications mediate LAT expression in allergic ast...

    Authors: Cheng-ye Li, Juan Peng, Lian-pin Ren, Li-xing Gan, Xiao-jiong Lu, Qian Liu, Wen Gu and Xue-jun Guo
    Citation: Journal of Translational Medicine 2013 11:26
  34. To mimic clinical treatment situations in advanced human ovarian disease, we tested the efficacy of CpG-oligodeoxynucleotides (CpG-ODN), synthetic DNA sequences recognized by Toll-like receptor 9 and able to i...

    Authors: Michele Sommariva, Michelandrea de Cesare, Alessandra Meini, Alessandra Cataldo, Nadia Zaffaroni, Elda Tagliabue and Andrea Balsari
    Citation: Journal of Translational Medicine 2013 11:25
  35. Ischemia/reperfusion injury plays a crucial role in renal transplantation, and represents a significant risk factor for acute renal failure and delayed graft function. The pathophysiological contribution of en...

    Authors: Wenli Yu, Mingwei Sheng, Rubin Xu, Jianjian Yu, Kang Cui, Jingkai Tong, Liying Shi, Hengchang Ren and Hongyin Du
    Citation: Journal of Translational Medicine 2013 11:24
  36. Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. CARs displayed on the surface of ...

    Authors: Satiro N De Oliveira, Jiexin Wang, Christine Ryan, Sherie L Morrison, Donald B Kohn and Roger P Hollis
    Citation: Journal of Translational Medicine 2013 11:23
  37. Kidneys derived from brain dead donors have lower graft survival and higher graft-function loss compared to their living donor counterpart. Heat Shock Proteins (HSP) are a large family of stress proteins invol...

    Authors: Leon FA van Dullemen, Eelke M Bos, Theo A Schuurs, Harm H Kampinga, Rutger J Ploeg, Harry van Goor and Henri GD Leuvenink
    Citation: Journal of Translational Medicine 2013 11:22
  38. Stem cell therapy is a promising treatment for cerebral palsy, which refers to a category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be a better cell s...

    Authors: Guojun Chen, Yali Wang, Zhenyu Xu, Feng Fang, Renmei Xu, Yue Wang, Xiaoli Hu, Lixing Fan and Houqi Liu
    Citation: Journal of Translational Medicine 2013 11:21
  39. Mesenchymal stem cells (MSC) can serve as carriers to deliver oncolytic measles virus (MV) to ovarian tumors. In preparation for a clinical trial to use MSC as MV carriers, we obtained cells from ovarian cance...

    Authors: Emily K Mader, Greg Butler, Sean C Dowdy, Andrea Mariani, Keith L Knutson, Mark J Federspiel, Stephen J Russell, Evanthia Galanis, Allan B Dietz and Kah-Whye Peng
    Citation: Journal of Translational Medicine 2013 11:20
  40. It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-

    Authors: Galina Shmarina, Alexander Pukhalsky, Nika Petrova, Ekaterina Zakharova, Lucine Avakian, Nikolai Kapranov and Vladimir Alioshkin
    Citation: Journal of Translational Medicine 2013 11:19
  41. ECBio has developed proprietary technology to consistently isolate, expand and cryopreserve a well-characterized population of stromal cells from human umbilical cord tissue (UCX® cells). The technology has re...

    Authors: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz and Helder Cruz
    Citation: Journal of Translational Medicine 2013 11:18
  42. We describe the long-term outcome after clinical introduction and dose escalation of somatostatin receptor targeted therapy with [90Y-DOTA]-TOC in patients with metastasized neuroendocrine tumors.

    Authors: Nicolas Marincek, Ann-Catherine Jörg, Philippe Brunner, Christian Schindler, Michael T Koller, Christoph Rochlitz, Jan Müller-Brand, Helmut R Maecke, Matthias Briel and Martin A Walter
    Citation: Journal of Translational Medicine 2013 11:17
  43. Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women ...

    Authors: Chandan Verma, Jennifer M Eremin, Adrian Robins, Andrew J Bennett, Gerard P Cowley, Mohamed A El-Sheemy, Jibril A Jibril and Oleg Eremin
    Citation: Journal of Translational Medicine 2013 11:16
  44. Anti-angiogenic therapies are among the most commonly used drugs in renal cell carcinoma. Tumor vascularity, defined by microvessel area, may be associated with response to these drugs. Clinical studies sugges...

    Authors: Saadia A Aziz, Joshua Sznol, Adebowale Adeniran, John W Colberg, Robert L Camp and Harriet M Kluger
    Citation: Journal of Translational Medicine 2013 11:15
  45. Pharmacologic reactivation of fetal hemoglobin expression is a promising strategy for treatment of sickle cell disease and β-thalassemia. The objective of this study was to investigate the effect of the methyl...

    Authors: Yinghong He, Gerhard Rank, Miaomiao Zhang, Junyi Ju, Ronghua Liu, Zhen Xu, Fiona Brown, Loretta Cerruti, Chi Ma, Renxiang Tan, Stephen M Jane and Quan Zhao
    Citation: Journal of Translational Medicine 2013 11:14
  46. Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis. Recently, Id1 has been identified as an independent...

    Authors: Eduardo Castañon, Joaquim Bosch-Barrera, Inés López, Víctor Collado, Marta Moreno, José María López-Picazo, Leire Arbea, María Dolores Lozano, Alfonso Calvo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2013 11:13
  47. Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has been associated with type 2 diabetes, but reported associations are inconsistent and data are lacking in Hispanic and African American pop...

    Authors: Jason H Karnes, Taimour Y Langaee, Caitrin W McDonough, Shin-Wen Chang, Miguel Ramos, James R Catlin Jr, Octavio E Casanova, Yan Gong, Carl J Pepine, Julie A Johnson and Rhonda M Cooper-DeHoff
    Citation: Journal of Translational Medicine 2013 11:12
  48. It has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders. However, to date, the direct biochemical/immu...

    Authors: Wojciech Błogowski, Marta Budkowska, Daria Sałata, Karol Serwin, Barbara Dołęgowska, Marek Łokaj, Piotr Prowans and Teresa Starzyńska
    Citation: Journal of Translational Medicine 2013 11:11

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