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  1. Endometrial regenerative cells (ERCs) are mesenchymal-like stem cells that can be non-invasively obtained from menstrual blood and are easily grown /generated at a large scale without tumorigenesis. We previou...

    Authors: Yongcheng Lv, Xiaoxi Xu, Bai Zhang, Guangying Zhou, Hongyue Li, Caigan Du, Hongqiu Han and Hao Wang
    Citation: Journal of Translational Medicine 2014 12:344
  2. Adrenomedullin (AM) is a regulatory peptide whose involvement in tumour progression is becoming more relevant with recent studies. AM is produced and secreted by the tumour cells but also by numerous stromal c...

    Authors: Ignacio M Larráyoz, Sonia Martínez-Herrero, Josune García-Sanmartín, Laura Ochoa-Callejero and Alfredo Martínez
    Citation: Journal of Translational Medicine 2014 12:339
  3. Dendritic cells are currently under investigation for their ability to generate anti-cancer immune responses. No consensus has been reached as to the optimal method of dendritic cell vaccine preparation and is...

    Authors: Mayu O Frank, Julia Kaufman, Salina Parveen, Nathalie E Blachère, Dana E Orange and Robert B Darnell
    Citation: Journal of Translational Medicine 2014 12:338
  4. Understanding the mechanisms by which some individuals are able to naturally control HIV-1 infection is an important goal of AIDS research. We here describe the case of an HIV-1+ woman, CASE1, who has spontaneous...

    Authors: Marco Moroni, Silvia Ghezzi, Paolo Baroli, Silvia Heltai, Davide De Battista, Simone Pensieroso, Mariangela Cavarelli, Stefania Dispinseri, Irene Vanni, Claudia Pastori, Pietro Zerbi, Antonella Tosoni, Elisa Vicenzi, Manuela Nebuloni, Kim Wong, Hong Zhao…
    Citation: Journal of Translational Medicine 2014 12:335
  5. The hypothesis that most cancers are of monoclonal origin is often accepted as a fact in the scientific community. This dogma arose decades ago, primarily from the study of hematopoietic malignancies and sarco...

    Authors: Sabahattin Comertpay, Sandra Pastorino, Mika Tanji, Rosanna Mezzapelle, Oriana Strianese, Andrea Napolitano, Francine Baumann, Tracey Weigel, Joseph Friedberg, Paul Sugarbaker, Thomas Krausz, Ena Wang, Amy Powers, Giovanni Gaudino, Shreya Kanodia, Harvey I Pass…
    Citation: Journal of Translational Medicine 2014 12:301
  6. GL261 cells are murine glioma cells that demonstrate proliferation, invasion, and angiogenesis when implanted in syngeneic C57BL/6 mice, providing a highly useful immunocompetent animal model of glioblastoma. ...

    Authors: Aaron J Clark, Michael Safaee, Taemin Oh, Michael E Ivan, Vamsi Parimi, Rintaro Hashizume, Tomoko Ozawa, Charles D James, Orin Bloch and Andrew T Parsa
    Citation: Journal of Translational Medicine 2014 12:345
  7. Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, oste...

    Authors: Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo and Na Lin
    Citation: Journal of Translational Medicine 2014 12:334

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:208

  8. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were found associated with body mass index (BMI)-defined obesity and lean mass.

    Authors: Laura Di Renzo, Luigi Tonino Marsella, Francesca Sarlo, Laura Soldati, Santo Gratteri, Ludovico Abenavoli and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2014 12:329
  9. Acute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential...

    Authors: Coert J Zuurbier, Andre Heinen, Anneke Koeman, Roy Stuifbergen, Theodorus BM Hakvoort, Nina C Weber and Markus W Hollmann
    Citation: Journal of Translational Medicine 2014 12:325
  10. Previously we demonstrated that the resection of primary 4T1 tumors only slightly prolongs mouse survival, but importantly, creates a “window of opportunity” with attenuated suppressor cell and increased activ...

    Authors: Anahit Ghochikyan, Alexey Pichugin, Alexander Bagaev, Arpine Davtyan, Armine Hovakimyan, Amir Tukhvatulin, Hayk Davtyan, Dmitry Shcheblyakov, Denis Logunov, Marina Chulkina, Anastasia Savilova, Dmitry Trofimov, Edward L Nelson, Michael G Agadjanyan and Ravshan I Ataullakhanov
    Citation: Journal of Translational Medicine 2014 12:322
  11. Chronic Obstructive Pulmonary Disease (COPD) is a major challenge for healthcare. Heterogeneities in clinical manifestations and in disease progression are relevant traits in COPD with impact on patient manage...

    Authors: Felip Miralles, David Gomez-Cabrero, Magí Lluch-Ariet, Jesper Tegnér, Marta Cascante and Josep Roca
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S12

    This article is part of a Supplement: Volume 12 Supplement 2

  12. The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiative...

    Authors: Marta Cascante, Pedro de Atauri, David Gomez-Cabrero, Peter Wagner, Josep Joan Centelles, Silvia Marin, Isaac Cano, Filip Velickovski, Igor Marin de Mas, Dieter Maier, Josep Roca and Philippe Sabatier
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S11

    This article is part of a Supplement: Volume 12 Supplement 2

  13. This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements -...

    Authors: Isaac Cano, Magí Lluch-Ariet, David Gomez-Cabrero, Dieter Maier, Susana Kalko, Marta Cascante, Jesper Tegnér, Felip Miralles, Diego Herrera and Josep Roca
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S10

    This article is part of a Supplement: Volume 12 Supplement 2

  14. The use of information and communication technologies to manage chronic diseases allows the application of integrated care pathways, and the optimization and standardization of care processes. Decision support...

    Authors: Filip Velickovski, Luigi Ceccaroni, Josep Roca, Felip Burgos, Juan B Galdiz, Nuria Marina and Magí Lluch-Ariet
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S9

    This article is part of a Supplement: Volume 12 Supplement 2

  15. The understanding of certain data often requires the collection of similar data from different places to be analysed and interpreted. Interoperability standards and ontologies, are facilitating data interchang...

    Authors: Magí Lluch-Ariet, Albert Brugués de la Torre, Francesc Vallverdú and Josep Pegueroles-Vallés
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S8

    This article is part of a Supplement: Volume 12 Supplement 2

  16. Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which ...

    Authors: Mercedes Huertas-Migueláñez, Daniel Mora, Isaac Cano, Dieter Maier, David Gomez-Cabrero, Magí Lluch-Ariet and Felip Miralles
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S7

    This article is part of a Supplement: Volume 12 Supplement 2

  17. Previously we generated a chronic obstructive pulmonary disease (COPD) specific knowledge base (http://​www.​copdknowledgebas​e.​eu) from clinical and experiment...

    Authors: Isaac Cano, Ákos Tényi, Christine Schueller, Martin Wolff, M Mercedes Huertas Migueláñez, David Gomez-Cabrero, Philipp Antczak, Josep Roca, Marta Cascante, Francesco Falciani and Dieter Maier
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S6

    This article is part of a Supplement: Volume 12 Supplement 2

  18. Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction and airflow limitation and pose a huge burden to society. These obstructive lung diseases impact the lung physiol...

    Authors: Kelly Suzanne Burrowes, Tom Doel and Chris Brightling
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S5

    This article is part of a Supplement: Volume 12 Supplement 2

  19. Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes a...

    Authors: David Gomez-Cabrero, Jörg Menche, Isaac Cano, Imad Abugessaisa, Mercedes Huertas-Migueláñez, Akos Tenyi, Igor Marin de Mas, Narsis A Kiani, Francesco Marabita, Francesco Falciani, Kelly Burrowes, Dieter Maier, Peter Wagner, Vitaly Selivanov, Marta Cascante, Josep Roca…
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S4

    This article is part of a Supplement: Volume 12 Supplement 2

  20. Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and management. Implicit...

    Authors: Josep Roca, Claudia Vargas, Isaac Cano, Vitaly Selivanov, Esther Barreiro, Dieter Maier, Francesco Falciani, Peter Wagner, Marta Cascante, Judith Garcia-Aymerich, Susana Kalko, Igor Marin De Mas, Jesper Tegnér, Joan Escarrabill, Alvar Agustí and David Gomez-Cabrero
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S3

    This article is part of a Supplement: Volume 12 Supplement 2

  21. Chronic diseases (CD) are generating a dramatic societal burden worldwide that is expected to persist over the next decades. The challenges posed by the epidemics of CD have triggered a novel health paradigm w...

    Authors: David Gomez-Cabrero, Magi Lluch-Ariet, Jesper Tegnér, Marta Cascante, Felip Miralles and Josep Roca
    Citation: Journal of Translational Medicine 2014 12(Suppl 2):S2

    This article is part of a Supplement: Volume 12 Supplement 2

  22. Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the clinical application of BBR is limited by its poor bioavailability. Derivatives of BBR have been sugg...

    Authors: Junwen Chen, Jiatian Cao, Lu Fang, Bo Liu, Qing Zhou, Yinggang Sun, Yue Wang, Yigang Li and Shu Meng
    Citation: Journal of Translational Medicine 2014 12:326
  23. Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prev...

    Authors: Qi Dong, Zhiye Wu, Xiaoyun Li, Jianyun Yan, Luning Zhao, Chuntao Yang, Junjiang Lu, Ju Deng and Minsheng Chen
    Citation: Journal of Translational Medicine 2014 12:323
  24. Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was des...

    Authors: Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa ZE Jaafar, Marius Moga and Muhammad Zia-Ul-Haq
    Citation: Journal of Translational Medicine 2014 12:316
  25. Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators,...

    Authors: Maria A Cavasin, Kimberly M Demos-Davies, Katherine B Schuetze, Weston W Blakeslee, Matthew S Stratton, Rubin M Tuder and Timothy A McKinsey
    Citation: Journal of Translational Medicine 2014 12:314
  26. Many current therapies for metastatic castration-resistant prostate cancer (mCRPC) are aimed at AR signaling; however, resistance to these therapies is inevitable. To personalize CRPC therapy in an individual ...

    Authors: Edwin E Reyes, David J VanderWeele, Masis Isikbay, Ryan Duggan, Alexa Campanile, Walter M Stadler, Donald J Vander Griend and Russell Z Szmulewitz
    Citation: Journal of Translational Medicine 2014 12:313
  27. Human Papilloma Virus (HPV) infection is the major cause of cervical cancer worldwide. With limited data available on HPV prevalence in the Arab countries, this study aimed to identify the prevalence and genot...

    Authors: Devendra Bansal, Asha A Elmi, Sini Skariah, Pascale Haddad, Laith J Abu-Raddad, Aysha H Al Hamadi, Nady Mohamed-Nady, Nahla M Affifi, Randa Ghedira, Elham Hassen, Asma AJ Al-Thani, Afaf AHM Al-Ansari and Ali A Sultan
    Citation: Journal of Translational Medicine 2014 12:300
  28. Although the efficacy of zoledronic acid in postmenopausal women with breast cancer has been suggested, the underlying mechanism has not been fully clarified. Therefore, which patients may benefit from zoledro...

    Authors: Eriko Sumi, Tomoharu Sugie, Kenichi Yoshimura, Harue Tada, Takafumi Ikeda, Eiji Suzuki, Yoshimasa Tanaka, Satoshi Teramukai, Akira Shimizu, Masakazu Toi and Nagahiro Minato
    Citation: Journal of Translational Medicine 2014 12:310
  29. Saliva has long been used as a sampling source for clinical diagnosis of oral disease such as oral squamous cell carcinoma, or therapeutic drug monitoring. The aims of this study was to ascertain if saliva RNA...

    Authors: Dongmei Chen, Najie Song, Runfang Ni, Jiangning Zhao, Jiasheng Hu, Quanyi Lu and Qingge Li
    Citation: Journal of Translational Medicine 2014 12:321
  30. Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorec...

    Authors: Jun Xiang, Lekun Fang, Yanxin Luo, Zuli Yang, Yi Liao, Ji Cui, Meijin Huang, Zihuan Yang, Yan Huang, Xinjuan Fan, Huashe Wang, Lei Wang, Junsheng Peng and Jianping Wang
    Citation: Journal of Translational Medicine 2014 12:320
  31. The role of miRNAs in familial breast cancer (fBC) is poorly investigated as also in the BRCA-like tumors. To identify a specific miRNA expression pattern which could allow a better fBC classification not only...

    Authors: Katia Danza, Simona De Summa, Brunella Pilato, Massimo Carella, Orazio Palumbo, Ondina Popescu, Angelo Paradiso, Rosamaria Pinto and Stefania Tommasi
    Citation: Journal of Translational Medicine 2014 12:319
  32. Cytomegalovirus (CMV)-specific T cell infusion to immunocompromised patients following allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is able to induce a successful anti-viral response. These c...

    Authors: Lorea Beloki, Miriam Ciaurriz, Cristina Mansilla, Amaya Zabalza, Estela Perez-Valderrama, Edward R Samuel, Mark W Lowdell, Natalia Ramirez and Eduardo Olavarria
    Citation: Journal of Translational Medicine 2014 12:317
  33. Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease that is characterized by both steatosis and severe injury in liver, still lacks efficient treatment. The traditional ...

    Authors: Yang Liu, Haiyan Song, Lei Wang, Hanchen Xu, Xiangbing Shu, Li Zhang, Ying Li, Dongfei Li and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:315
  34. Growing awareness of the complexity of carcinogenesis has made multimodal therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy has gained acceptance as an active therapeuti...

    Authors: Anna R Kwilas, Andressa Ardiani, Renee N Donahue, Dana T Aftab and James W Hodge
    Citation: Journal of Translational Medicine 2014 12:294
  35. Hereditary hearing loss is genetically heterogeneous, and hundreds of mutations in than 60 genes are involved in this disease. Therefore, it is difficult to identify the causative gene mutations involved. In t...

    Authors: Qinjun Wei, Hongmei Zhu, Xuli Qian, Zhibin Chen, Jun Yao, Yajie Lu, Xin Cao and Guangqian Xing
    Citation: Journal of Translational Medicine 2014 12:311
  36. Regulatory T cells (Tregs) and B cells (Bregs) play an important role in the development of lung cancer. The present study aimed to investigate the phenotype of circulating Tregs and Bregs in patients with lun...

    Authors: Jiebai Zhou, Zhihui Min, Ding Zhang, William Wang, Francesco Marincola and Xiangdong Wang
    Citation: Journal of Translational Medicine 2014 12:304
  37. This study aimed to explore the role of apoptosis initiators, caspase-9, caspase-10, mitochondrial anti-viral signaling protein (MAVS), and interferon regulatory factor 7 (pIRF7), in patients with systemic lup...

    Authors: Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2014 12:303
  38. MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC...

    Authors: Yi Zhu, Jing-Jing Zhang, Kun-Ling Xie, Jie Tang, Wen-Biao Liang, Rong Zhu, Yan Zhu, Bin Wang, Jin-Qiu Tao, Xiao-Fei Zhi, Zheng Li, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao and Ze-Kuan Xu
    Citation: Journal of Translational Medicine 2014 12:309
  39. Natural killer (NK) cells are abundant in the liver and constitute a major innate immune component that contributes to immune-mediated liver injury. However, few studies have investigated the phenotypes and fu...

    Authors: Min Zhang, Fenglan Wang, Yutian Chong, Qiang Tai, Qiyi Zhao, Yubao Zheng, Liang Peng, Shumei Lin and Zhiliang Gao
    Citation: Journal of Translational Medicine 2014 12:308
  40. The Aurora family of serine-threonine kinases are essential regulators of cell division in mammalian cells. Aurora-A and -B expression and kinase activity is elevated in a variety of human cancers and is assoc...

    Authors: Gloria Juan, Tammy L Bush, Connie Ma, Raffi Manoukian, Grace Chung, Jennifer M Hawkins, Stephen Zoog, Richard Kendall, Robert Radinsky, Robert Loberg, Greg Friberg and Marc Payton
    Citation: Journal of Translational Medicine 2014 12:307
  41. Endometriosis is a benign chronic gynecological disease that affects women of reproductive age, characterized by the presence of functional endometrial tissues outside the uterine cavity. GnRH agonists exhibit...

    Authors: Huinan Weng, Fenghua Liu, Shuiwang Hu, Li Li and Yifeng Wang
    Citation: Journal of Translational Medicine 2014 12:306
  42. MicroRNA-200c (miR-200c) is one of the short noncoding RNAs that play crucial roles in tumorigenesis and tumor progression. It also acts as considerable modulator in the process of epithelial-to-mesenchymal tr...

    Authors: Lei Liu, Mingning Qiu, Guobin Tan, Ziji Liang, Yue Qin, Lieqian Chen, Hege Chen and Jianjun Liu
    Citation: Journal of Translational Medicine 2014 12:305

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:153

  43. Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could preve...

    Authors: Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng and Shu Zhang
    Citation: Journal of Translational Medicine 2014 12:302
  44. The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2,...

    Authors: Marco Genua, Sergio Rutella, Carmen Correale and Silvio Danese
    Citation: Journal of Translational Medicine 2014 12:293
  45. There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association of Diab...

    Authors: Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongsu Liu, Ling Dong, Zhijie Yu, Gang Hu and Juliana CN Chan
    Citation: Journal of Translational Medicine 2014 12:290

    The Erratum to this article has been published in Journal of Translational Medicine 2015 13:70

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