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  2. Cell-based bioassays have been suggested for screening of hormones and drug bioactivities. They are a plausible alternative to animal based methods. The technique used is called receptor/reporter system. Recep...

    Authors: Shrikant S Betrabet, Jyoti Choudhuri and Manjit Gill-Sharma
    Citation: Journal of Translational Medicine 2004 2:1
    Content type: Research Published on:

  3. The interferon-γ (IFN-γ) ELISPOT assay is one of the most useful techniques for immunological monitoring of cancer vaccine trials and has gained increased application as a measure of specific T cell activation...

    Authors: Kimberly Shafer-Weaver, Thomas Sayers, Susan Strobl, Eric Derby, Tracy Ulderich, Michael Baseler and Anatoli Malyguine
    Citation: Journal of Translational Medicine 2003 1:14
    Content type: Methodology Published on:

  4. To evaluate a panel of pretreatment clinical and laboratory parameters in metastatic melanoma (MM) in order to verify their impact on response and survival in a single prospective multi-institutional phase III...

    Authors: Michele Guida, Alessandra Ravaioli, Vanna Chiarion Sileni, Antonella Romanini, Roberto Labianca, Antonio Freschi, Salvatore Brugnara, Addolorata Casamassima, Vito Lorusso, Oriana Nanni and Ruggero Ridolfi
    Citation: Journal of Translational Medicine 2003 1:13
    Content type: Research Published on:

  5. The identification and characterization of viral epitopes across the Human Leukocyte Antigen (HLA) polymorphism is critical for the development of actives-specific or adoptive immunotherapy of virally-mediated...

    Authors: Maurizio Provenzano, Simone Mocellin, Paola Bonginelli, Dirk Nagorsen, Seog-Woon Kwon and David Stroncek
    Citation: Journal of Translational Medicine 2003 1:12
    Content type: Methodology Published on:

  7. Chronic fatigue syndrome (CFS) has no diagnostic clinical signs or diagnostic laboratory abnormalities and it is unclear if it represents a single illness. The CFS research case definition recommends stratifyi...

    Authors: Toni Whistler, Elizabeth R Unger, Rosane Nisenbaum and Suzanne D Vernon
    Citation: Journal of Translational Medicine 2003 1:10
    Content type: Research Published on:

  8. While the use of high-resolution molecular typing in routine matching of h uman l eukocyte a ntigens (HLA) is expected to improve unrelated donor selection and transplant outcome, the genetic complexity of HLA st...

    Authors: Daniel Ramon, Megan Braden, Sharon Adams, Francesco M Marincola and Lu Wang
    Citation: Journal of Translational Medicine 2003 1:9
    Content type: Methodology Published on:

  10. Dendritic cells (DC) are increasingly prepared in vitro for use in immunotherapy trials. Mature DC express high levels of surface molecules needed for T cell activation and are superior at antigen-presentation th...

    Authors: Gopi Shankar, Linda A Pestano and Marnix L Bosch
    Citation: Journal of Translational Medicine 2003 1:7
    Content type: Research Published on:

  11. Macrophages can produce vascular endothelial growth factor (VEGF) in response to hypoxia, transforming growth factor β1 (TGF-β1), angiotensin II, basic fibroblast growth factor (bFGF), and interleukin-1. These...

    Authors: Dimitrios Panutsopulos, Alexandros Zafiropoulos, Elias Krambovitis, George E Kochiadakis, Nikos E Igoumenidis and Demetrios A Spandidos
    Citation: Journal of Translational Medicine 2003 1:6
    Content type: Research Published on:

  12. Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer...

    Authors: Bohuslav Melichar, Wei Hu, Rebecca Patenia, Karolina Melicharová, Stacie T Gallardo and Ralph Freedman
    Citation: Journal of Translational Medicine 2003 1:5
    Content type: Research Published on:

  13. Detection of unknown single nucleotide polymorphism (SNP) relies on large scale sequencing expeditions of genomic fragments or complex high-throughput chip technology. We describe a simplified strategy for flu...

    Authors: Ena Wang, Sharon Adams, Yingdong Zhao, Monica Panelli, Richard Simon, Harvey Klein and Francesco M Marincola
    Citation: Journal of Translational Medicine 2003 1:4
    Content type: Methodology Published on:

  14. The matrix protein of the influenza A virus and the matrix and capsid proteins of the human immunodeficiency virus (HIV) share striking structural similarities which may have evolutionary and biological signif...

    Authors: Paula M Acierno, Danforth A Newton, Edwin A Brown, Lou Anne Maes, John E Baatz and Sebastiano Gattoni-Celli
    Citation: Journal of Translational Medicine 2003 1:3
    Content type: Research Published on:

  15. The landscape for cancer research is profoundly different today from that only one decade ago. Basic science is moving rapidly and biotechnological revolutions in molecular targeting and immunology have comple...

    Authors: Frederic Lehmann, Denis Lacombe, Patrick Therasse and Alexander MM Eggermont
    Citation: Journal of Translational Medicine 2003 1:2
    Content type: Commentary Published on:

  16. The purpose of translational research is to test, in humans, novel therapeutic strategies developed through experimentation. Translational research should be regarded as a two-way road: Bench to Bedside and Be...

    Authors: Francesco M Marincola
    Citation: Journal of Translational Medicine 2003 1:1
    Content type: Editorial Published on:
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