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  1. Downregulation of the putative tumor suppressor gene SLC22A18 has been reported in a number of human cancers. The aim of this study was to investigate the relationship between SLC22A18 downregulation, promoter me...

    Authors: Sheng-Hua Chu, Dong-Fu Feng, Yan-Bin Ma, Hong Zhang, Zhi-An Zhu, Zhi-Qiang Li and Pu-Cha Jiang
    Citation: Journal of Translational Medicine 2011 9:156
  2. Recent positive clinical results in cancer immunotherapy point to the potential of immune-based strategies to provide effective treatment of a variety of cancers. In some patients, the responses to cancer immu...

    Authors: Davide Bedognetti, James M Balwit, Ena Wang, Mary L Disis, Cedrik M Britten, Lucia G Delogu, Sara Tomei, Bernard A Fox, Thomas F Gajewski, Francesco M Marincola and Lisa H Butterfield
    Citation: Journal of Translational Medicine 2011 9:155
  3. The deafness-associated gene mutation profile varies greatly among regions and races. Due to the multi-ethnic coalition of over one thousand years, non-syndromic deafness (NSD) patients of Uyghur ethnicity may...

    Authors: Yu Chen, Mayila Tudi, Jie Sun, Chao He, Hong-li Lu, Qing Shang, Di Jiang, Pilidong Kuyaxi, Bin Hu and Hua Zhang
    Citation: Journal of Translational Medicine 2011 9:154
  4. The Cancer/Testis Antigens (CTAs) are an important group of proteins that are typically restricted to the testis in the normal adult but are aberrantly expressed in several types of cancers. As a result of the...

    Authors: Takumi Shiraishi, Naoki Terada, Yu Zeng, Takahito Suyama, Jun Luo, Bruce Trock, Prakash Kulkarni and Robert H Getzenberg
    Citation: Journal of Translational Medicine 2011 9:153
  5. Cancer is one of the most difficult current health challenges, being responsible for millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach, and the prevailing orientation cal...

    Authors: Enrico P Spugnini, Sylvie M Renaud, Sabrina Buglioni, Francesca Carocci, Emanuele Dragonetti, Raffaele Murace, Pierluigi Cardelli, Bruno Vincenzi, Alfonso Baldi and Gennaro Citro
    Citation: Journal of Translational Medicine 2011 9:152
  6. Active dendritic cell (DC) immunization protocols are rapidly gaining interest as therapeutic options in patients with acute myeloid leukemia (AML). Here we present for the first time a GMP-compliant 3-day pro...

    Authors: Barbara Beck, Daniela Dörfel, Felix S Lichtenegger, Christiane Geiger, Lysann Lindner, Martina Merk, Dolores J Schendel and Marion Subklewe
    Citation: Journal of Translational Medicine 2011 9:151
  7. Stem cell homing to the heart is mediated by the release of chemo-attractant cytokines. Stromal derived factor -1 alpha (SDF-1a) and monocyte chemotactic factor 1(MCP-1) are detectable in peripheral blood afte...

    Authors: Andrew J Boyle, Yerem Yeghiazarians, Henry Shih, Joy Hwang, Jianqin Ye, Rich Sievers, Daiwei Zheng, Jath Palasubramaniam, Dharshan Palasubramaniam, Connie Karschimkus, Robert Whitbourn, Alicia Jenkins and Andrew M Wilson
    Citation: Journal of Translational Medicine 2011 9:150
  8. With the approval of the first therapeutic cancer vaccines for veterinarian and human use, the field reached a significant milestone after a considerable interval of tumultuous research and development marked ...

    Authors: Adrian Bot, Mihail Obrocea and Francesco M Marincola
    Citation: Journal of Translational Medicine 2011 9:148
  9. Infection with high risk Human Papilloma Virus (HPV) is associated with cancer of the cervix, vagina, penis, vulva, anus and some cases of head and neck carcinomas. The HPV derived oncoproteins E6 and E7 are c...

    Authors: Kirsten BJ Scholten, Annelies W Turksma, Janneke J Ruizendaal, Muriel van den Hende, Sjoerd H van der Burg, Mirjam HM Heemskerk, Chris JLM Meijer and Erik Hooijberg
    Citation: Journal of Translational Medicine 2011 9:147
  10. The advent of high-throughput technology challenges the traditional histopathological classification of cancer, and proposes new taxonomies derived from global transcriptional patterns. Although most of these ...

    Authors: Maria Libera Ascierto, Valeria De Giorgi, Qiuzhen Liu, Davide Bedognetti, Tara L Spivey, Daniela Murtas, Lorenzo Uccellini, Ben D Ayotte, David F Stroncek, Lotfi Chouchane, Masoud H Manjili, Ena Wang and Francesco M Marincola
    Citation: Journal of Translational Medicine 2011 9:146
  11. Both endothelial progenitor cells (EPC) and markers of neuroinflammation are candidate biomarkers for stroke severity and outcome prediction. A relationship between EPC and neuroinflammatory markers in early s...

    Authors: Tanya Bogoslovsky, Maria Spatz, Aneeka Chaudhry, Dragan Maric, Marie Luby, Joseph Frank and Steven Warach
    Citation: Journal of Translational Medicine 2011 9:145
  12. The syndrome of resistance to thyroid hormone (RTH) is caused by mutations in the thyroid hormone receptor β gene (THRB). The syndrome varies from asymptomatic to diffuse hypothyroidism, to pituitary-selective re...

    Authors: Anna Teresa Alberobello, Valentina Congedo, Hong Liu, Craig Cochran, Monica C Skarulis, Douglas Forrest and Francesco S Celi
    Citation: Journal of Translational Medicine 2011 9:144
  13. The ability to measure T-cell responses to antigens is proving critical in the field of vaccine development and for understanding immunity to pathogens, allergens and self-antigens. Although a variety of techn...

    Authors: Aron Chakera, Sophia C Bennett and Richard J Cornall
    Citation: Journal of Translational Medicine 2011 9:143
  14. Human melanoma frequently colonizes bone marrow (BM) since its earliest stage of systemic dissemination, prior to clinical metastasis occurrence. However, how melanoma cell adhesion and proliferation mechanism...

    Authors: María Valcárcel, Lorea Mendoza, José-Julio Hernández, Teresa Carrascal, Clarisa Salado, Olatz Crende and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2011 9:142
  15. This study tested the superiority of combined cyclosporine A (CsA)-erythropoietin (EPO) therapy compared with either one in limiting brain infarction area (BIA) and preserving neurological function in rat afte...

    Authors: Chun-Man Yuen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Ying-Hsien Kao, Chia-Hung Yen, Yung-Lung Chen, Tzu-Hsien Tsai, Sarah Chua, Pei-Lin Shao, Steve Leu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:141
  16. Active-specific immunotherapy used as an adjuvant therapeutic strategy is rather unexplored for cancers with poorly characterized tumor antigens like gastric cancer. The aim of this study was to augment a ther...

    Authors: Natasja K van den Engel, Dominik Rüttinger, Margareta Rusan, Robert Kammerer, Wolfgang Zimmermann, Rudolf A Hatz and Hauke Winter
    Citation: Journal of Translational Medicine 2011 9:140
  17. Chronic inflammation plays an important role in head and neck squamous cell carcinomas (HNSCC). This study addresses the impact of two single nucleotide polymorphisms (SNP) Asp299Gly and Thr399Ile of the toll-...

    Authors: Christoph Bergmann, Hagen S Bachmann, Agnes Bankfalvi, Ramin Lotfi, Carolin Pütter, Clarissa A Wild, Patrick J Schuler, Jens Greve, Thomas K Hoffmann, Stephan Lang, André Scherag and Götz F Lehnerdt
    Citation: Journal of Translational Medicine 2011 9:139
  18. T cell therapy represents an emerging and promising modality for the treatment of both infectious disease and cancer. Data from recent clinical trials have highlighted the potential for this therapeutic modali...

    Authors: Michael Kalos
    Citation: Journal of Translational Medicine 2011 9:138
  19. Viral vectors provide a method of stably introducing exogenous DNA into cells that are not easily transfectable allowing for the ectopic expression or silencing of genes for therapeutic or experimental purpose...

    Authors: Christine V Ichim and Richard A Wells
    Citation: Journal of Translational Medicine 2011 9:137
  20. Fat mass (FM) in overweight/obese subjects has a primary role in determining low-grade chronic inflammation and, in turn, insulin resistance (IR) and ectopic lipid storage within the liver. Obesity, aging, and...

    Authors: Silvia Savastano, Carolina Di Somma, Genoveffa Pizza, Annalba De Rosa, Valeria Nedi, Annalisa Rossi, Francesco Orio, Gaetano Lombardi, Annamaria Colao and Giovanni Tarantino
    Citation: Journal of Translational Medicine 2011 9:136
  21. Human β-defensins (hBD) are antimicrobial peptides that are an integral part of bone innate immunity. Recently, it could be shown that expression of hBD-1, -2 and -3 were upregulated in cases of osteomyelitis ...

    Authors: Philipp Stockmann, Falk Wehrhan, Stephan Schwarz-Furlan, Florian Stelzle, Susanne Trabert, Friedrich W Neukam and Emeka Nkenke
    Citation: Journal of Translational Medicine 2011 9:135
  22. The Miyahira-Araujo Fuzzy Obesity Index (MAFOI) for being used as an alternative in bariatric surgery indication (BSI) is validated in this paper. The search for a more accurate method to evaluate obesity and ...

    Authors: Susana Abe Miyahira, João Luiz Moreira Coutinho de Azevedo and Ernesto Araújo
    Citation: Journal of Translational Medicine 2011 9:134
  23. PI3K and mTOR are key components of signal transduction pathways critical for cell survival. Numerous PI3K inhibitors have entered clinical trials, while mTOR is the target of approved drugs for metastatic ren...

    Authors: Aymen A Elfiky, Saadia A Aziz, Patricia J Conrad, Summar Siddiqui, Wolfgang Hackl, Michel Maira, Camp L Robert and Harriet M Kluger
    Citation: Journal of Translational Medicine 2011 9:133
  24. Cardiomyocyte calcium overloading has been implicated in the pathogenesis of Duchenne muscular dystrophy (DMD) heart disease. The cardiac isoform of sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a majo...

    Authors: Jin-Hong Shin, Brian Bostick, Yongping Yue, Roger Hajjar and Dongsheng Duan
    Citation: Journal of Translational Medicine 2011 9:132
  25. Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL numbers or tumor tissues challenges their clinica...

    Authors: Qunrui Ye, Maria Loisiou, Bruce L Levine, Megan M Suhoski, James L Riley, Carl H June, George Coukos and Daniel J Powell Jr
    Citation: Journal of Translational Medicine 2011 9:131
  26. Metastasis is a common feature of many advanced stage cancers and metastatic spread is thought to be responsible for cancer progression. Most cancer cells are localized in the primary tumor and only a small po...

    Authors: Mirosław Andrusiewicz, Anna Szczerba, Maria Wołuń-Cholewa, Wojciech Warchoł, Ewa Nowak-Markwitz, Emilia Gąsiorowska, Krystyna Adamska and Anna Jankowska
    Citation: Journal of Translational Medicine 2011 9:130
  27. Clinician-researchers and experimental scientists do not speak the same language; they have different professional environments and different end-points in their research. This creates considerable problems of...

    Authors: Pierre R Smeesters, Marie Deghorain and Andrew C Steer
    Citation: Journal of Translational Medicine 2011 9:128
  28. Numerous pre-clinical studies and clinical trials demonstrated that induction of antibodies to the β-amyloid peptide of 42 residues (Aβ42) elicits therapeutic effects in Alzheimer's disease (AD). However, an acti...

    Authors: Hayk Davtyan, Anahit Ghochikyan, Richard Cadagan, Dmitriy Zamarin, Irina Petrushina, Nina Movsesyan, Luis Martinez-Sobrido, Randy A Albrecht, Adolfo García-Sastre and Michael G Agadjanyan
    Citation: Journal of Translational Medicine 2011 9:127
  29. Head and neck squamous cell carcinoma (HNSCC) still remains a lethal malignancy benefiting from the identification of the new target for early detection and/or development of new therapeutic regimens based on ...

    Authors: Mikiko Takikita, Ran Xie, Joon-Yong Chung, Hanbyoul Cho, Kris Ylaya, Seung-Mo Hong, Christopher A Moskaluk and Stephen M Hewitt
    Citation: Journal of Translational Medicine 2011 9:126
  30. Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is limited by the lack of efficient...

    Authors: Enrico P Spugnini, Annamaria Biroccio, Roberta De Mori, Marco Scarsella, Carmen D'Angelo, Alfonso Baldi and Carlo Leonetti
    Citation: Journal of Translational Medicine 2011 9:125
  31. Liver transplantation is the definitive treatment for many end-stage liver diseases. However, the life-long immunosuppression needed to prevent graft rejection causes clinically significant side effects. Cellu...

    Authors: Felix C Popp, Barbara Fillenberg, Elke Eggenhofer, Philipp Renner, Johannes Dillmann, Volker Benseler, Andreas A Schnitzbauer, James Hutchinson, Robert Deans, Deborah Ladenheim, Cheryl A Graveen, Florian Zeman, Michael Koller, Martin J Hoogduijn, Edward K Geissler, Hans J Schlitt…
    Citation: Journal of Translational Medicine 2011 9:124
  32. Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rat...

    Authors: Maria Garcia-Fernandez, Inma Sierra, Juan E Puche, Lucia Guerra and Inma Castilla-Cortazar
    Citation: Journal of Translational Medicine 2011 9:123
  33. Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs) against melanoma commonly target melanoma-associated antigens (MAAs) which are also expressed by melanoc...

    Authors: Gwendolen Y Chang, Holbrook E Kohrt, Tor B Stuge, Erich J Schwartz, Jeffrey S Weber and Peter P Lee
    Citation: Journal of Translational Medicine 2011 9:122
  34. RNA quality is believed to decrease with ischaemia time, and therefore open radical prostatectomy has been advantageous in allowing the retrieval of the prostate immediately after its devascularization. In con...

    Authors: Harveer Dev, David Rickman, Prasanna Sooriakumaran, Abhishek Srivastava, Sonal Grover, Robert Leung, Robert Kim, Naoki Kitabayashi, Raquel Esqueva, Kyung Park, Jessica Padilla, Mark Rubin and Ashutosh Tewari
    Citation: Journal of Translational Medicine 2011 9:121
  35. Several proteins that promote angiogenesis are overexpressed in hepatocellular carcinoma (HCC) and have been implicated in disease pathogenesis. Sunitinib has antiangiogenic activity and is an oral multitarget...

    Authors: Charles S Harmon, Samuel E DePrimo, Eric Raymond, Ann-Lii Cheng, Eveline Boucher, Jean-Yves Douillard, Ho Y Lim, Jun S Kim, Maria José Lechuga, Silvana Lanzalone, Xun Lin and Sandrine Faivre
    Citation: Journal of Translational Medicine 2011 9:120
  36. Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.

    Authors: Joanna D Holbrook, Joel S Parker, Kathleen T Gallagher, Wendy S Halsey, Ashley M Hughes, Victor J Weigman, Peter F Lebowitz and Rakesh Kumar
    Citation: Journal of Translational Medicine 2011 9:119
  37. This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury.

    Authors: Cheuk-Kwan Sun, Chia-Hung Yen, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Ying-Hsien Kao, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Steve Leu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:118
  38. We have previously reported that expression of the RNA- and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistoc...

    Authors: Liv Jonsson, Julia Bergman, Björn Nodin, Jonas Manjer, Fredrik Pontén, Mathias Uhlén and Karin Jirström
    Citation: Journal of Translational Medicine 2011 9:114
  39. Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with vari...

    Authors: Hyun Ok Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin and Sungha Park
    Citation: Journal of Translational Medicine 2011 9:113
  40. Hepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment with interferon plus ribavirin, has ...

    Authors: Usman A Ashfaq, Muhammad S Masoud, Zafar Nawaz and Sheikh Riazuddin
    Citation: Journal of Translational Medicine 2011 9:112
  41. Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pat...

    Authors: Baoying Liu, Lai Wei, Catherine Meyerle, Jingsheng Tuo, H Nida Sen, Zhiyu Li, Sagarika Chakrabarty, Elvira Agron, Chi-Chao Chan, Michael L Klein, Emily Chew, Frederick Ferris and Robert B Nussenblatt
    Citation: Journal of Translational Medicine 2011 9:111
  42. Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of pre...

    Authors: Christopher Moy, Catherine A Oleykowski, Ramona Plant, Joel Greshock, Junping Jing, Kurtis Bachman, Mary Ann Hardwicke, Richard Wooster and Yan Degenhardt
    Citation: Journal of Translational Medicine 2011 9:110
  43. Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue ext...

    Authors: Binbin Chen and Manu O Platt
    Citation: Journal of Translational Medicine 2011 9:109
  44. The introduction of antibody markers to identify undesired cell populations in flow-cytometry based assays, so called DUMP channel markers, has become a practice in an increasing number of labs performing HLA-...

    Authors: Sebastian Attig, Leah Price, Sylvia Janetzki, Michael Kalos, Michael Pride, Lisa McNeil, Tim Clay, Jianda Yuan, Kunle Odunsi, Axel Hoos, Pedro Romero and Cedrik M Britten
    Citation: Journal of Translational Medicine 2011 9:108
  45. The field of cellular therapy of cancer is moving quickly and the issues involved with its advancement are complex and wide ranging. The growing clinical applications and success of adoptive cellular therapy o...

    Authors: Cornelis JM Melief, John J O'Shea and David F Stroncek
    Citation: Journal of Translational Medicine 2011 9:107

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