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Table 4 Cox model with hazard ratios and 95% confidence intervals of Chronic fatigue syndrome associated with medications

From: Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study

Variable

Chronic fatigue syndrome

Event

PY

IR

cHR (95% CI)

p-value

aHR (95% CI)

p-value

Medication

 Doxycycline

  No

33,349

7,133,590

4.67

1.00 (reference)

–

1.00 (reference)

–

  Yes

23

50,788

0.45

0.1 (0.06, 0.15)***

< 0.001

0.1 (0.07, 0.15)***

< 0.001

 Azithromycin

  No

33,342

7,087,311

4.70

1.00 (reference)

–

1.00 (reference)

–

  Yes

30

97,066

0.31

0.07 (0.05, 0.09)***

< 0.001

0.07 (0.05, 0.1)***

< 0.001

 Clarithromycin

  No

33,341

7,178,084

4.64

1.00 (reference)

–

1.00 (reference)

–

  Yes

31

6294

4.93

1.05 (0.74, 1.49)

0.7818

1 (0.7, 1.42)

0.9838

 Moxifloxacin

  No

33,350

7,099,137

4.70

1.00 (reference)

–

1.00 (reference)

–

  Yes

22

85,241

0.26

0.06 (0.04, 0.08)***

< 0.001

0.05 (0.04, 0.08)***

< 0.001

 Levofloxacin

  No

33,346

7,048,173

4.73

1.00 (reference)

–

1.00 (reference)

–

  Yes

26

136,205

0.19

0.04 (0.03, 0.06)***

< 0.001

0.04 (0.03, 0.06)***

< 0.001

 Ciprofloxacin

  No

33,356

7,176,747

4.65

1.00 (reference)

–

1.00 (reference)

–

  Yes

16

7630

2.10

0.45 (0.28, 0.74)**

0.0015

0.51 (0.31, 0.83)**

0.0071

  1. PY Person-Year; IR Incidence rate, per 1000 persons/years; HR Hazard ratio; CI confidence interval; Adjusted HR adjusted for age, sex, comorbidities and medications in Cox proportional hazards regression
  2. *p < 0.05, **p < 0.01, ***p < 0.001
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Journal of Translational Medicine

ISSN: 1479-5876

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