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Table 3 Cox model with hazard ratios and 95% confidence intervals of Chronic fatigue syndrome associated with comorbidities

From: Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study

Variable

Chronic fatigue syndrome

Event

PY

IR

cHR

(95% CI)

p-value

aHR

(95% CI)

p-value

Comorbidities

 Hypothyroidism

  No

33,327

7,177,484

4.64

1.00 (reference)

1.00 (reference)

  Yes

45

6894

6.53

1.43 (1.06, 1.91)*

0.0173

1.08 (0.8, 1.44)

0.6134

 Diabetes mellitus

  No

29,855

6,687,346

4.46

1.00 (reference)

1.00 (reference)

  Yes

3517

497,032

7.08

1.59 (1.54, 1.65)***

< 0.001

1.05 (1.01, 1.09)*

0.0133

 Insomnia

  No

29,282

6,717,076

4.36

1.00 (reference)

1.00 (reference)

  Yes

4090

467,302

8.75

2.01 (1.95, 2.08)***

< 0.001

1.32 (1.27, 1.37)***

< 0.001

 Depression

  No

31,603

6,971,899

4.53

1.00 (reference)

1.00 (reference)

-

  Yes

1769

212,479

8.33

1.83 (1.75, 1.92)***

< 0.001

1.07 (1.01, 1.13)*

0.0126

 Anxiety

  No

26,926

6,368,646

4.23

1.00 (reference)

1.00 (reference)

  Yes

6446

815,732

7.90

1.87 (1.81, 1.92)***

< 0.001

1.29 (1.24, 1.33)***

< 0.001

 Dementia

  No

33,350

7,180,108

4.64

1.00 (reference)

1.00 (reference)

  Yes

22

4270

5.15

1.2 (0.79, 1.82)

0.3981

0.65 (0.42, 0.98)*

0.0409

 Peptic ulcer

  No

25,618

6,086,581

4.21

1.00 (reference)

1.00 (reference)

  Yes

7754

1,097,797

7.06

1.68 (1.63, 1.72)***

< 0.001

1.22 (1.18, 1.25)***

< 0.001

 Obesity

  No

33,168

7,149,700

4.64

1.00 (reference)

1.00 (reference)

  Yes

204

34,677

5.88

1.27 (1.1, 1.45)***

< 0.001

1.01 (0.88, 1.16)

0.8833

 Psoriasis

  No

33,233

7,153,937

4.65

1.00 (reference)

1.00 (reference)

  Yes

139

30,441

4.57

0.98 (0.83, 1.16)

0.8347

0.85 (0.72, 1)

0.0511

 Burn

  No

32,570

7,047,627

4.62

1.00 (reference)

1.00 (reference)

  Yes

802

136,750

5.86

1.27 (1.18, 1.36)***

< 0.001

1.06 (0.99, 1.14)

0.0855

 Gout

  No

30,481

6,771,447

4.50

1.00 (reference)

1.00 (reference)

  Yes

2891

412,930

7.00

1.55 (1.49, 1.61)***

< 0.001

1.16 (1.11, 1.21)***

< 0.001

 Dyslipidemia

  No

29,181

6,620,858

4.41

1.00 (reference)

1.00 (reference)

  Yes

4191

563,519

7.44

1.7 (1.64, 1.76)***

< 0.001

1.1 (1.06, 1.14)***

< 0.001

 Inflammatory bowel syndrome

  No

31,201

6,902,039

4.52

1.00 (reference)

1.00 (reference)

  Yes

2171

282,339

7.69

1.7 (1.63, 1.77)***

< 0.001

1.15 (1.1, 1.21)***

< 0.001

 Hepatitis B

  No

32,492

7,052,148

4.61

1.00 (reference)

1.00 (reference)

  Yes

880

132,230

6.66

1.44 (1.34, 1.54)***

< 0.001

1.21 (1.13, 1.3)***

< 0.001

 Hepatitis C

  No

32,993

7,148,144

4.62

1.00 (reference)

1.00 (reference)

  Yes

379

36,233

10.46

2.27 (2.06, 2.52)***

< 0.001

1.54 (1.39, 1.71)***

< 0.001

 Fibromyalgia

  No

25,843

6,103,927

4.23

1.00 (reference)

1.00 (reference)

  Yes

7529

1,080,451

6.97

1.64 (1.6, 1.69)***

< 0.001

1.29 (1.26, 1.33)***

< 0.001

  1. PY Person-Year; IR Incidence rate, per 1000 persons/years; HR Hazard ratio; CI confidence interval; Adjusted HR adjusted for age, sex, comorbidities and medications in Cox proportional hazards regression
  2. *p < 0.05, **p < 0.01, ***p < 0.001