Variable | Chronic fatigue syndrome | ||||||
---|---|---|---|---|---|---|---|
Event | PY | IR | cHR (95% CI) | p-value | aHR (95% CI) | p-value | |
Comorbidities | |||||||
Hypothyroidism | |||||||
No | 33,327 | 7,177,484 | 4.64 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 45 | 6894 | 6.53 | 1.43 (1.06, 1.91)* | 0.0173 | 1.08 (0.8, 1.44) | 0.6134 |
Diabetes mellitus | |||||||
No | 29,855 | 6,687,346 | 4.46 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 3517 | 497,032 | 7.08 | 1.59 (1.54, 1.65)*** | < 0.001 | 1.05 (1.01, 1.09)* | 0.0133 |
Insomnia | |||||||
No | 29,282 | 6,717,076 | 4.36 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 4090 | 467,302 | 8.75 | 2.01 (1.95, 2.08)*** | < 0.001 | 1.32 (1.27, 1.37)*** | < 0.001 |
Depression | |||||||
No | 31,603 | 6,971,899 | 4.53 | 1.00 (reference) | – | 1.00 (reference) | - |
Yes | 1769 | 212,479 | 8.33 | 1.83 (1.75, 1.92)*** | < 0.001 | 1.07 (1.01, 1.13)* | 0.0126 |
Anxiety | |||||||
No | 26,926 | 6,368,646 | 4.23 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 6446 | 815,732 | 7.90 | 1.87 (1.81, 1.92)*** | < 0.001 | 1.29 (1.24, 1.33)*** | < 0.001 |
Dementia | |||||||
No | 33,350 | 7,180,108 | 4.64 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 22 | 4270 | 5.15 | 1.2 (0.79, 1.82) | 0.3981 | 0.65 (0.42, 0.98)* | 0.0409 |
Peptic ulcer | |||||||
No | 25,618 | 6,086,581 | 4.21 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 7754 | 1,097,797 | 7.06 | 1.68 (1.63, 1.72)*** | < 0.001 | 1.22 (1.18, 1.25)*** | < 0.001 |
Obesity | |||||||
No | 33,168 | 7,149,700 | 4.64 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 204 | 34,677 | 5.88 | 1.27 (1.1, 1.45)*** | < 0.001 | 1.01 (0.88, 1.16) | 0.8833 |
Psoriasis | |||||||
No | 33,233 | 7,153,937 | 4.65 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 139 | 30,441 | 4.57 | 0.98 (0.83, 1.16) | 0.8347 | 0.85 (0.72, 1) | 0.0511 |
Burn | |||||||
No | 32,570 | 7,047,627 | 4.62 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 802 | 136,750 | 5.86 | 1.27 (1.18, 1.36)*** | < 0.001 | 1.06 (0.99, 1.14) | 0.0855 |
Gout | |||||||
No | 30,481 | 6,771,447 | 4.50 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 2891 | 412,930 | 7.00 | 1.55 (1.49, 1.61)*** | < 0.001 | 1.16 (1.11, 1.21)*** | < 0.001 |
Dyslipidemia | |||||||
No | 29,181 | 6,620,858 | 4.41 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 4191 | 563,519 | 7.44 | 1.7 (1.64, 1.76)*** | < 0.001 | 1.1 (1.06, 1.14)*** | < 0.001 |
Inflammatory bowel syndrome | |||||||
No | 31,201 | 6,902,039 | 4.52 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 2171 | 282,339 | 7.69 | 1.7 (1.63, 1.77)*** | < 0.001 | 1.15 (1.1, 1.21)*** | < 0.001 |
Hepatitis B | |||||||
No | 32,492 | 7,052,148 | 4.61 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 880 | 132,230 | 6.66 | 1.44 (1.34, 1.54)*** | < 0.001 | 1.21 (1.13, 1.3)*** | < 0.001 |
Hepatitis C | |||||||
No | 32,993 | 7,148,144 | 4.62 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 379 | 36,233 | 10.46 | 2.27 (2.06, 2.52)*** | < 0.001 | 1.54 (1.39, 1.71)*** | < 0.001 |
Fibromyalgia | |||||||
No | 25,843 | 6,103,927 | 4.23 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 7529 | 1,080,451 | 6.97 | 1.64 (1.6, 1.69)*** | < 0.001 | 1.29 (1.26, 1.33)*** | < 0.001 |