Variable | Chronic fatigue syndrome | ||||||
---|---|---|---|---|---|---|---|
Event | PY | IR | cHR (95% CI) | p-value | aHR (95% CI) | p-value | |
Cohort with infection | |||||||
No | 11,511 | 3,137,363 | 3.67 | 1.00 (reference) | – | 1.00 (reference) | – |
Yes | 21,861 | 4,047,015 | 5.40 | 1.5 (1.46, 1.53)*** | 0.001 | 1.5 (1.47, 1.54)*** | 0.001 |
Pathogens | |||||||
Cohort without infection | 11,511 | 3,137,363 | 3.67 | 1.00 (reference) | – | 1.00 (reference) | – |
Varicella-zoster virus | 2382 | 481,446 | 4.95 | 1.36 (1.3, 1.42)*** | < 0.001 | 1.09 (1.04, 1.14)*** | < 0.001 |
Epstein-Barr virus | 6 | 1122 | 5.35 | 1.47 (0.66, 3.28) | 0.3437 | 1.71 (0.77, 3.81) | 0.1881 |
Mycobacterium tuberculosis | 641 | 111,209 | 5.76 | 1.59 (1.47, 1.73)*** | < 0.001 | 1.45 (1.34, 1.57)*** | < 0.001 |
E. coli | 350 | 60,035 | 5.83 | 1.62 (1.46, 1.8)*** | < 0.001 | 1.17 (1.05, 1.3)** | 0.0052 |
Candida | 3878 | 767,616 | 5.05 | 1.39 (1.34, 1.44)*** | < 0.001 | 1.43 (1.37, 1.48)*** | < 0.001 |
Enterovirus | 29 | 4396 | 6.60 | 1.84 (1.27, 2.64)** | 0.0011 | 1.86 (1.29, 2.67)*** | < 0.001 |
Salmonella | 137 | 26,687 | 5.13 | 1.42 (1.2, 1.68)*** | < 0.001 | 1.41 (1.19, 1.67)*** | < 0.001 |
Staphylococcus aureus | 71 | 11,970 | 5.93 | 1.65 (1.3, 2.08)*** | < 0.001 | 1.38 (1.09, 1.74)** | 0.0075 |
Chlamydia pneumoniae | 3 | 748 | 4.01 | 1.09 (0.35, 3.39) | 0.8784 | 0.93 (0.3, 2.87) | 0.8937 |
Influenza virus | 14,219 | 2,546,888 | 5.58 | 1.56 (1.52, 1.6)*** | < 0.001 | 1.67 (1.63, 1.71)*** | < 0.001 |
Orientia tsutsugamushi | 18 | 3629 | 4.96 | 1.35 (0.85, 2.14) | 0.2037 | 1.38 (0.87, 2.19) | 0.1756 |
Mycoplasma | 80 | 21,456 | 3.73 | 1.03 (0.82, 1.28) | 0.8089 | 0.93 (0.75, 1.16) | 0.5387 |
Dengue virus | 44 | 9559 | 4.60 | 1.32 (0.98, 1.78) | 0.0638 | 1.22 (0.91, 1.64) | 0.185 |
Borrelia burgdorferi | 3 | 255 | 11.77 | 3.21 (1.04, 9.91)* | 0.0425 | 3.37 (1.09, 10.44)* | 0.0355 |
Sex | |||||||
Female | 20,794 | 4,283,422 | 4.85 | 1.00 (reference) | – | 1.00 (reference) | – |
Male | 12,578 | 2,900,956 | 4.34 | 0.89 (0.87, 0.91)*** | < 0.001 | 0.91 (0.89, 0.93)*** | < 0.001 |
Age (years) | |||||||
< 40 | 14,080 | 3,724,544 | 3.78 | 1.00 (reference) | – | 1.00 (reference) | – |
40–64 | 13,936 | 2,730,127 | 5.10 | 1.35 (1.32, 1.39)*** | < 0.001 | 1.2 (1.17, 1.23)*** | < 0.001 |
65+ | 5356 | 729,706 | 7.34 | 1.97 (1.91, 2.03)*** | < 0.001 | 1.59 (1.54, 1.65)*** | < 0.001 |