Table 1 Clinical characteristics of the enrolled participants
From: Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Parameter | Healthy controls (n = 18) | Cirrhosis (n = 20) | HCC-cirrhosis (n = 34) | P-valuesa | P-valuesb |
|---|---|---|---|---|---|
Age (year) | 57.5 (46.6–64.0) | 57.0 (53.0–61.0) | 57.5 (48.5–66.5) | 0.672 | 0.830 |
BMI (kg/m2) | 22.8 (20.7–25.4) | 23.0 (21.0–24.9) | 23.1 (20.5–24.0) | 0.610 | 0.929 |
Gender | |||||
 Female | 3 (16.67%) | 4 (20.00%) | 7 (20.59%) | 1.00 | 1.00 |
 Male | 15 (83.33%) | 16 (80.00%) | 27 (79.41%) | ||
Cirrhosis etiology | |||||
 Hepatitis B virus | – | 16(80.00%) | 27 (79.41%) | – | 1.00 |
 NAFLD | – | 4 (20.00%) | 7 (20.59%) | ||
Child–Pugh | |||||
 A | – | 18 (90.00%) | 31 (91.18%) | – | 1.00 |
 B | – | 2 (10.00%) | 3 (8.82%) | ||
 ALT (9-50U/L) | 24.0 (18.5–31.1) | 33.0 (26.3–40.8) | 34.0 (19.8–56.3) | 0.043 | 0.687 |
 AST (15-40U/L) | 26.3 (22.0–31.3) | 38.5 (30.0–51.0) | 43.5 (33.5–107.8) |  < 0.001 | 0.117 |
 Albumin (40-55 g/L) | 43.6 (42.0–47.6) | 42.3 (38.0–47.2) | 37.4 (33.4–42.3) |  < 0.001 | 0.003 |
 Globulin (20-40 g/L) | 26.0 (22.7–30.7) | 27.7 (26.2–29.3) | 26.9 (24.8–32.1) | 0.281 | 0.740 |
 TBIL (0-23 μmol/L) | 13.7 (12.8–19.0) | 16.3 (13.2–19.7) | 20.9 (14.3–25.2) | 0.035 | 0.144 |
 DBIL (0-8 μmol/L) | 6.20 (4.2–7.2) | 6.8 (5.5–11.9) | 8.3 (5.1–11.4) | 0.022 | 0.957 |
 PT (9-13 s) | – | 11.4 (10.5–12.5) | 12.1 (11.0–13.0) | – | 0.147 |
 Platelet (125–350 10E9/L) | 229.5 (204.6–252.2) | 193.0 (173.0–241.0) | 175.0 (122.0–236.8) | 0.015 | 0.457 |
 Dietary habit | Mixed diet | Mixed diet | Mixed diet | – | – |