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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor

Fig. 4

Under standard conditions CDK4/6, directed by upstream signaling, phosphorylates RB1 promoting E2F transcription and cell cycle progression from G1 to S. CDK4/6 inhibitors block this pathway, causing cells to stall at G1. This blockage in the cell cycle reduces uptake of thymidine and therefore of [18F]FLT

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Journal of Translational Medicine

ISSN: 1479-5876

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