Fig. 5

Ex vivo differential metabolites pathway analysis between the PTX-sensitive and PTX-resistant tumors and the correlation between in vivo and ex vivo differential metabolites. Composition of ex vivo differential metabolites (A). Linear discriminant analysis effect size of ex vivo differential metabolites (B). Pathway enrichment analysis of differential metabolites between the OV and OV_PTX groups (C). Metabolic alterations of the most relevant pathways affected by drug resistance were analyzed by MetaboAnalyst 3.0 databases. Correlation heat map of differential metabolites between in vivo and ex vivo metabolite profiles (D). Each square represents a metabolite and the colour corresponds to its correlation coefficient value compared with other metabolites