Fig. 7
Metabolomic analysis. A Heat map comparisons of differential metabolite alterations between groups. The heatmap was generated with MetaboAnalyst 5.0 using normalized data (log transformation, Auto scaling) and Euclidean distance. B Enrichment analysis. Metabolite set enrichment analysis (MSEA) was conducted to evaluate the impact of individual metabolite alterations between the placebo and H2 groups. MSEA identified d-glutamine and d-glutamate metabolism (FDR = 1.62 × 10−2) as significantly discriminated among the groups. C Changes in plasma l-glutamic acid after CA/ECPR with and without H2 (one-way repeated-measures ANOVA followed by Sidak’s correction, F = 8.33)