Table 5 Final cluster solution–differences in development of symptoms and functions over time (baseline to week 30 follow-up)
Cluster | 1: Pain tolerant & good cognitions (n = 40) | 2: Restored HPA dynamics (n = 15) | 3: Orthostatic intolerance (n = 20) | 4: Low-grade inflammation (n = 4) | 5: Pain intolerant & poor cognitions (n = 33) | 6: High vagal activity (n = 3) | p-valuea |
|---|---|---|---|---|---|---|---|
Δ CFQ-mean [95% CI] | − 5.0 [− 7.6, − 2.4] | − 5.0 [− 10.5, 0.5] | − 4.8 [− 7.6, − 2.0] | − 6.5 [n.a] | − 5.2 [− 8.1, − 2.2] | 4.0 [n.a.] | 0.999 |
Δ PEM-mean [95% CI] | − 0.48 [− 0.9, 0.0] | − 0.36 [− 1.4, 0.6] | 0.12 [− 0.2, 0.4] | − 1.00 [n.a.] | − 0.73 [− 1.2, − 0.3] | − 1.0 [n.a.] | 0.130 |
Δ MFQ-mean [95% CI] | − 1.0 [− 4.1, 2.1] | − 1.7 [− 7.4, 3.9] | − 0.2 [− 3.6, 3.1] | − 4.7 [n.a.] | − 3.1 [− 6.8, 0.5] | − 3.0 [n.a.] | 0.685 |
Δ Steps per day-mean [95% CI] | 526 [− 593, 1644] | − 1107 [− 3004, 789] | − 578 [− 1506, 350] | 1228 [n.a.] | 283 [− 532, 1099] | − 657 [n.a.] | 0.218 |
Δ FDI-mean [95% CI] | − 3.1 [− 6.2, 0.1] | − 1.9 [− 8.2, 4.4] | 0.6 [− 3.4, 4.6] | − 13.0 [n.a.] | − 6.7 [− 10.8, − 2.5] | − 9.5 [n.a.] | 0.079 |
Δ PedsQL-mean [95% CI] | 6.6 [0.8, 12.5] | 5.8 [− 6.4, 18.1] | 2.5 [− 2.7, 7.7] | 6.9 [n.a.] | 8.4 [4.3, 12.5] | 14.2 [n.a.] | 0.584 |