Table 3 Linear regression models to demonstrate associations between clinical and flow cytometry derived cell populations and hsCRP as biomarker for CVD risk
|  | FRS β-coefficient (p-value) | hsCRP (mg/l) β-coefficient (p-value) | ||
|---|---|---|---|---|
Unadjusted | Adj. for BMI | Unadjusted | Adj. for BMI/age | |
Clinical neutrophil population (%) | 0.49 (0.03) | 0.49 (0.04) | − 0.08 (0.73) | − 0.06 (0.79) |
FCD neutrophil population (%) | 0.46 (0.04) | 0.49 (0.04) | 0.08 (0.73) | − 0.04 (0.87) |
Clinical eosinophil population (%) | − 0.05 (0.84) | − 0.05 (0.85) | − 0.04 (0.88) | 0.16 (0.50) |
FCD eosinophil population (%) | 0.22 (0.36) | 0.22 (0.36) | − 0.19 (0.43) | − 0.13 (0.58) |
Clinical basophil population (%) | 0.36 (0.12) | 0.36 (0.14) | − 0.13 (0.59) | − 0.16 (0.49) |
FCD basophil population (%) | 0.20 (0.39) | 0.21 (0.39) | − 0.24 (0.31) | − 0.18 (0.45) |
Clinical monocyte population (%) | 0.38 (0.097) | 0.38 (0.11) | − 0.35 (0.13) | − 0.37 (0.10) |
FCD monocyte population (%) | − 0.20 (0.40) | − 0.20 (0.42) | − 0.36 (0.12) | − 0.32 (0.15) |
Clinical lymphocyte population (%) | − 0.53 (0.02) | − 0.55 (0.02) | 0.18 (0.45) | 0.10 (0.66) |
FCD T cell population (%) | − 0.47 (0.04) | − 0.47 (0.04) | 0.10 (0.68) | 0.14 (0.57) |
FCD B cell population (%) | − 0.196 (0.41) | − 0.20 (0.42) | 0.18 (0.44) | 0.35 (0.18) |
FCD NK cell population (%) | − 0.085 (0.72) | − 0.09 (0.72) | − 0.07 (0.77) | − 0.15 (0.52) |
FCD NKT cell population (%) | − 0.020 (0.93) | − 0.02 (0.94) | 0.22 (0.27) | 0.28 (0.20) |
FCD cell-platelet aggregate (PA) | ||||
 Neutrophils-PA | 0.18 (0.45) | 0.21 (0.44) | 0.58 (0.01) | 0.49 (0.04) |
 Eosinophils-PA | 0.20 (0.39) | 0.22 (0.39) | 0.58 (0.01) | 0.49 (0.03) |
 Basophils-PA | 0.13 (0.58) | 0.13 (0.60) | 0.22 (0.36) | 0.17 (0.46) |
 T cells-PA | 0.45 (0.05) | 0.59 (0.03) | 0.52 (0.02) | 0.41 (0.11) |
 B cells-PA | 0.27 (0.24) | 0.35 (0.20) | 0.46 (0.04) | 0.31 (0.21) |
 NK cells-PA | 0.44 (0.05) | 0.55 (0.03) | 0.55 (0.01) | 0.45 (0.07) |
 NKT cells-PA | 0.43 (0.06) | 0.53 (0.04) | 0.45 (0.04) | 0.32 (0.20) |
 All monocyte-PA | 0.24 (0.32) | 0.24 (0.33) | 0.23 (0.33) | 0.19 (0.39) |
 Classical monocyte-PA | 0.19 (0.42) | 0.19 (0.43) | 0.22 (0.34) | 0.19 (0.39) |
 Intermediate monocyte-PA | 0.18 (0.44) | 0.18 (0.46) | 0.23 (0.34) | 0.23 (0.32) |
 Nonclassical monocyte-PA | 0.52 (0.02) | 0.54 (0.02) | 0.28 (0.23) | 0.20 (0.40) |