Parameter | Femur | Tibia | ||
---|---|---|---|---|
Medial | Lateral | Medial | Lateral | |
Trabecular bone volume (mm3) | ||||
 Sham-vehicle | 7.8 ± 0.4 | 5.9 ± 0.3 | 9.7 ± 0.7 | 10.7 ± 0.6* |
 ACLT-vehicle | 6.7 ± 0.3 | 4.8 ± 0.3 | 7.6 ± 0.7 | 8.1 ± 0.7 |
 ACLT-low dose | 7.0 ± 0.7 | 5.3 ± 0.5 | 8.9 ± 0.7 | 9.9 ± 0.7 |
 ACLT-high dose | 7.2 ± 0.5 | 5.5 ± 0.2 | 9.5 ± 0.5 | 10.3 ± 0.4* |
Connective density (1/mm3) | ||||
 Sham-vehicle | 8.00 ± 0.31 | 8.63 ± 0.50 | 5.79 ± 0.30* | 11.35 ± 1.04* |
 ACLT-vehicle | 9.30 ± 0.75 | 12.12 ± 1.65 | 9.93 ± 1.29 | 18.17 ± 2.35 |
 ACLT-low dose | 11.42 ± 1.61 | 13.51 ± 1.54 | 9.20 ± 1.08 | 16.55 ± 1.95 |
 ACLT-high dose | 9.14 ± 0.63 | 11.90 ± 1.51 | 8.47 ± 0.69 | 16.25 ± 2.01 |
Structure model index | ||||
 Sham-vehicle | 0.35 ± 0.13 | 0.62 ± 0.09 | 0.53 ± 0.09 | 0.52 ± 0.11 |
 ACLT-vehicle | 0.30 ± 0.06 | 1.02 ± 0.09 | 0.79 ± 0.17 | 0.78 ± 0.19 |
 ACLT-low dose | 0.48 ± 0.07 | 0.73 ± 0.15 | 0.52 ± 0.16 | 0.51 ± 0.12 |
 ACLT-high dose | 0.40 ± 0.07 | 0.63 ± 0.11 | 0.41 ± 0.10 | 0.42 ± 0.11 |
Trabecular number (1/mm) | ||||
 Sham-vehicle | 3.22 ± 0.28 | 2.32 ± 0.27 | 2.03 ± 0.15 | 2.88 ± 0.18 |
 ACLT-vehicle | 2.79 ± 0.10 | 2.19 ± 0.09 | 1.94 ± 0.17 | 2.63 ± 0.14 |
 ACLT-low dose | 3.02 ± 0.20 | 2.58 ± 0.16 | 2.05 ± 0.08 | 2.96 ± 0.15 |
 ACLT-high dose | 3.71 ± 0.68 | 2.55 ± 0.10 | 2.09 ± 0.15 | 3.01 ± 0.16 |
Trabecular thickness (mm) | ||||
 Sham-vehicle | 0.24 ± 0.00 | 0.21 ± 0.01 | 0.28 ± 0.01 | 0.24 ± 0.01* |
 ACLT-vehicle | 0.22 ± 0.01 | 0.19 ± 0.01 | 0.23 ± 0.01 | 0.19 ± 0.01 |
 ACLT-low dose | 0.22 ± 0.03 | 0.18 ± 0.01 | 0.25 ± 0.02 | 0.21 ± 0.01 |
 ACLT-high dose | 0.22 ± 0.02 | 0.19 ± 0.01 | 0.26 ± 0.00 | 0.22 ± 0.01 |
Trabecular separation (mm) | ||||
 Sham-vehicle | 0.32 ± 0.03 | 0.48 ± 0.08 | 0.50 ± 0.04 | 0.35 ± 0.02 |
 ACLT-vehicle | 0.36 ± 0.01 | 0.46 ± 0.02 | 0.54 ± 0.05 | 0.39 ± 0.02 |
 ACLT-low dose | 0.34 ± 0.02 | 0.40 ± 0.03 | 0.49 ± 0.02 | 0.34 ± 0.02 |
 ACLT-high dose | 0.30 ± 0.03 | 0.40 ± 0.02 | 0.50 ± 0.04 | 0.34 ± 0.02 |
Bone surface (mm2) | ||||
 Sham-vehicle | 103.6 ± 3.6 | 93.9 ± 4.8 | 116.8 ± 4.1 | 143.6 ± 4.6 |
 ACLT-vehicle | 101.7 ± 1.9 | 90.2 ± 2.3 | 119.2 ± 6.2 | 144.4 ± 4.4 |
 ACLT-low dose | 105.6 ± 3.8 | 101.2 ± 4.3 | 124.9 ± 3.3 | 153.6 ± 4.1 |
 ACLT-high dose | 105.2 ± 1.3 | 101.7 ± 2.9 | 124.9 ± 4.6 | 152.7 ± 4.1 |
Bone surface/volume (1/mm) | ||||
 Sham-vehicle | 13.4 ± 0.2 | 16.0 ± 0.5 | 12.2 ± 0.6* | 13.6 ± 0.6* |
 ACLT-vehicle | 15.4 ± 0.8 | 19.3 ± 1.6 | 16.1 ± 1.1 | 18.5 ± 1.5 |
 ACLT-low dose | 16.0 ± 1.6 | 19.9 ± 1.3 | 14.6 ± 1.2 | 16.0 ± 1.2 |
 ACLT-high dose | 15.1 ± 1.0 | 18.7 ± 0.8 | 13.2 ± 0.2 | 14.9 ± 0.5 |
Tissue mineral density (mgHA/ccm) | ||||
 Sham-vehicle | 733.2 ± 9.2 | 709.1 ± 8.9* | 743.0 ± 7.8 | 717.8 ± 8.4 |
 ACLT-vehicle | 697.6 ± 8.6 | 670.5 ± 9.2 | 702.2 ± 11.4 | 680.2 ± 11.0 |
 ACLT-low dose | 698.4 ± 15.7 | 669.6 ± 8.4 | 714.1 ± 13.1 | 700.8 ± 10.6 |
 ACLT-high dose | 699.1 ± 10.3 | 673.6 ± 7.0 | 726.9 ± 5.5 | 707.0 ± 6.6 |