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Table 2 Rabbit ACLT study—µCT data from trabecular bone

From: The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

Parameter Femur Tibia
Medial Lateral Medial Lateral
Trabecular bone volume (mm3)
 Sham-vehicle 7.8 ± 0.4 5.9 ± 0.3 9.7 ± 0.7 10.7 ± 0.6*
 ACLT-vehicle 6.7 ± 0.3 4.8 ± 0.3 7.6 ± 0.7 8.1 ± 0.7
 ACLT-low dose 7.0 ± 0.7 5.3 ± 0.5 8.9 ± 0.7 9.9 ± 0.7
 ACLT-high dose 7.2 ± 0.5 5.5 ± 0.2 9.5 ± 0.5 10.3 ± 0.4*
Connective density (1/mm3)
 Sham-vehicle 8.00 ± 0.31 8.63 ± 0.50 5.79 ± 0.30* 11.35 ± 1.04*
 ACLT-vehicle 9.30 ± 0.75 12.12 ± 1.65 9.93 ± 1.29 18.17 ± 2.35
 ACLT-low dose 11.42 ± 1.61 13.51 ± 1.54 9.20 ± 1.08 16.55 ± 1.95
 ACLT-high dose 9.14 ± 0.63 11.90 ± 1.51 8.47 ± 0.69 16.25 ± 2.01
Structure model index
 Sham-vehicle 0.35 ± 0.13 0.62 ± 0.09 0.53 ± 0.09 0.52 ± 0.11
 ACLT-vehicle 0.30 ± 0.06 1.02 ± 0.09 0.79 ± 0.17 0.78 ± 0.19
 ACLT-low dose 0.48 ± 0.07 0.73 ± 0.15 0.52 ± 0.16 0.51 ± 0.12
 ACLT-high dose 0.40 ± 0.07 0.63 ± 0.11 0.41 ± 0.10 0.42 ± 0.11
Trabecular number (1/mm)
 Sham-vehicle 3.22 ± 0.28 2.32 ± 0.27 2.03 ± 0.15 2.88 ± 0.18
 ACLT-vehicle 2.79 ± 0.10 2.19 ± 0.09 1.94 ± 0.17 2.63 ± 0.14
 ACLT-low dose 3.02 ± 0.20 2.58 ± 0.16 2.05 ± 0.08 2.96 ± 0.15
 ACLT-high dose 3.71 ± 0.68 2.55 ± 0.10 2.09 ± 0.15 3.01 ± 0.16
Trabecular thickness (mm)
 Sham-vehicle 0.24 ± 0.00 0.21 ± 0.01 0.28 ± 0.01 0.24 ± 0.01*
 ACLT-vehicle 0.22 ± 0.01 0.19 ± 0.01 0.23 ± 0.01 0.19 ± 0.01
 ACLT-low dose 0.22 ± 0.03 0.18 ± 0.01 0.25 ± 0.02 0.21 ± 0.01
 ACLT-high dose 0.22 ± 0.02 0.19 ± 0.01 0.26 ± 0.00 0.22 ± 0.01
Trabecular separation (mm)
 Sham-vehicle 0.32 ± 0.03 0.48 ± 0.08 0.50 ± 0.04 0.35 ± 0.02
 ACLT-vehicle 0.36 ± 0.01 0.46 ± 0.02 0.54 ± 0.05 0.39 ± 0.02
 ACLT-low dose 0.34 ± 0.02 0.40 ± 0.03 0.49 ± 0.02 0.34 ± 0.02
 ACLT-high dose 0.30 ± 0.03 0.40 ± 0.02 0.50 ± 0.04 0.34 ± 0.02
Bone surface (mm2)
 Sham-vehicle 103.6 ± 3.6 93.9 ± 4.8 116.8 ± 4.1 143.6 ± 4.6
 ACLT-vehicle 101.7 ± 1.9 90.2 ± 2.3 119.2 ± 6.2 144.4 ± 4.4
 ACLT-low dose 105.6 ± 3.8 101.2 ± 4.3 124.9 ± 3.3 153.6 ± 4.1
 ACLT-high dose 105.2 ± 1.3 101.7 ± 2.9 124.9 ± 4.6 152.7 ± 4.1
Bone surface/volume (1/mm)
 Sham-vehicle 13.4 ± 0.2 16.0 ± 0.5 12.2 ± 0.6* 13.6 ± 0.6*
 ACLT-vehicle 15.4 ± 0.8 19.3 ± 1.6 16.1 ± 1.1 18.5 ± 1.5
 ACLT-low dose 16.0 ± 1.6 19.9 ± 1.3 14.6 ± 1.2 16.0 ± 1.2
 ACLT-high dose 15.1 ± 1.0 18.7 ± 0.8 13.2 ± 0.2 14.9 ± 0.5
Tissue mineral density (mgHA/ccm)
 Sham-vehicle 733.2 ± 9.2 709.1 ± 8.9* 743.0 ± 7.8 717.8 ± 8.4
 ACLT-vehicle 697.6 ± 8.6 670.5 ± 9.2 702.2 ± 11.4 680.2 ± 11.0
 ACLT-low dose 698.4 ± 15.7 669.6 ± 8.4 714.1 ± 13.1 700.8 ± 10.6
 ACLT-high dose 699.1 ± 10.3 673.6 ± 7.0 726.9 ± 5.5 707.0 ± 6.6
  1. p < 0.05; vs. ACLT-vehicle group