Table 2 Clinical trials using stem/progenitor cell-based therapeutics in RD
From: Progress of stem/progenitor cell-based therapy for retinal degeneration
Cell therapy | Identifier | Phase | Institution | Location | Principal investigator | Study start date | Study status | Diseases and enrolment | Single dose | Months of follow-up | Intervention | Safety issues | Visual acuity and number of patients | Other trials | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Improved | Stable | Decreased | ||||||||||||||
hRPCs | NCT02320812 | I/IIa | jCyte | California, US | Henry Klassen | June 2015 | Ongoing but not enrolling patients | 28 RP | 500,000 –3,000,000 cells | 12 | Intravitreal | No data | No data | No data | No data | ReNeuron (Boston: Phase I/II, 15 RP) |
ESCs → RPE | NCT01345006 | I/II | Advanced Cell Technologies | California, US | Steven Schwartz | April 2011 | Completed | 9 SMD | 50,000–150,000 cells | 22 | Subretinal | None | 10 | 7 | 1 | Pfizer [London: Phase I, 10 AMD (wet)] |
NCT01344993 | 9 AMD (dry) | |||||||||||||||
NCT01625559 | I | CHABiotech | Seoul, South Korea | Won Kyung Song | September 2012 | Unknown | 2 SMD | 50,000Â cells | 12 | Subretinal | None | 3 | 1 | None | ||
NCT01674829 | I/IIa | 2 AMD (dry) | ||||||||||||||
NCT02286089 | I/II | Cell Cure Neuroscience | Jerusalem, Israel | Ytzhak Hemo | April 2015 | Enrolling patients | 15 AMD (dry) | 50,000–500,000 cells | 12 | Subretinal | No data | No data | No data | No data | ||
iPSCs → RPE | UMIN000011929 | I | RIKEN | Kobe, Japan | Masayo Takahashi | September 2014 | Suspended | 1 AMD (wet) | 1.3 mm × 3 mm RPE sheet | 12 | Subretinal | None | None | 1 | None | National Eye Institute (Preclinical, AMD) |
BM-MSCs | NCT01068561 | I | University of Sao Paulo | São Pauloin, Brazil | Rubens C Siqueira | May 2009 | Completed | 3 RP and 2 cone-rod dystrophy | 10,000,000 cells | 10 | Intravitreal | None | 4 | 1 | None | Red de Terapia Celular (Spain: Phase I, 10 RP); Al-Azhar University [Egypt: Phase I/II, 1 AMD (dry)] |
NCT01560715 | II | January 2011 | Completed | 20 RP | 12 | 20 (transitorily) | None | None | ||||||||
BM CD34+ cells | NCT01736059 | I | University of California, Davis | California, US | Susanna S Park | July 2012 | Enrolling patients | 6 RD or ischaemic disorders | 3,400,000 cells | 6 | Intravitreal | None | 6 | None | None | |