Skip to main content

Table 1 Characteristics of mother-newborn pairs according to self-reported tobacco smoke exposure during pregnancy

From: Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight

Variable

All

(n = 382)

Non-smokers

(n = 255)

Past-smokers

(n = 65)

Smokers

(n = 62)

p value*

Newborn

 Sex

    

0.47

  Male

188 (49.2%)

120 (47.1%)

34 (52.3%)

34 (54.8%)

 

  Female

194 (50.8%)

135 (52.9%)

31 (47.7%)

28 (45.2%)

 

 Ethnicity

    

0.73

  European-Caucasian

332 (86.9%)

223 (87.4%)

57 (87.7%)

52 (83.9%)

 

  Non-European

50 (13.1%)

32 (12.6%)

8 (12.3%)

10 (16.1%)

 

 Gestational age, w

39.2 ± 1.2

39.3 ± 1.2

39.2 ± 1.3

39.2 ± 1.2

0.82

 Birth weight, g

3429 ± 426

3472 ± 424

3437 ± 423

3247 ± 395

0.0009

 Birth length, cm

50.3 ± 1.9

50.5 ± 2.0

50.5 ± 1.7

49.5 ± 1.8

0.0007

Mother

 Age, year

29.0 ± 4.7

29.4 ± 4.5

28.9 ± 4.9

27.7 ± 4.8

0.03

 Pre-pregnancy BMI, kg/m2

24.3 ± 4.5

24.2 ± 4.4

24.8 ± 5.3

24.2 ± 4.1

0.65

 Maternal education

    

<0.0001

  Low

51 (13.3%)

26 (10.2%)

6 (9.2%)

19 (30.6%)

 

  Middle

131 (34.3%)

77 (30.2%)

25 (38.5%)

29 (46.8%)

 

  High

200 (52.4%)

152 (59.6%)

34 (52.3%)

14 (22.6%)

 

 Medication usea

    

0.57

  None

134 (37.8%)

92 (39.5%)

21 (32.3%)

21 (37.5%)

 

 Alcohol consumption

    

0.03

  Occasionally

73 (19.1%)

42 (16.5%)

20 (30.8%)

11 (17.7%)

 

 Physical activity (>20 min)b

    

0.40

  <1 times per week

122 (33.3%)

82 (33.3%)

19 (29.7%)

21 (36.8%)

 

  1 times per week

86 (23.4%)

63 (25.6%)

15 (23.4%)

8 (14.0%)

 

  >2 times per week

159 (43.3%)

101 (41.1%)

30 (46.9%)

28 (49.2%)

 

 Parity

    

0.42

  1

200 (52.3%)

132 (51.8%)

36 (55.4%)

32 (51.6%)

 

  2

142 (37.2%)

91 (35.7%)

25 (38.5%)

26 (41.9%)

 

  ≥3

40 (10.5%)

32 (12.5%)

4 (6.1%)

4 (6.5%)

 

 Cigarettes before pregnancy

–

–

11.0 ± 6.9

10.3 ± 6.7

 

 Cigarettes during pregnancy

–

–

–

7.8 ± 4.6

 
  1. Data are presented as arithmetic mean ± standard deviation (SD) or number (%)
  2. * p value derived from one-way ANOVA or Chi square tests in case of continuous or categorical variables respectively
  3. aMedication use: occasional use of paracetamol or antibiotics (28 missing data)
  4. bMissing data for 15 subjects