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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

Fig. 5

IL-21 enhances CD4+ and CD8+ TSCM expansion. Naïve T cells from healthy donors (n = 3) were cultured for 10 days and fold expansion were analyzed in short costimulation (solid black line), long costimulation (solid grey line) short + IL-21 (black dashed line) and long + IL-21 (grey dashed line) conditions. a, b Absolute fold expansion of CD4+ (a) and CD8+ (b) (mean ± SEM), expressed in increment of cells from the starting culture time point is shown. c, d Absolute fold expansion of CD4+ (c) and CD8+ (d) total TSCM (TSCM + TSCM-like) (mean ± SEM). *p < 0.05; **p < 0.01; ***p < 0.001

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