Fig. 2
High levels of S. Typhi-specific CD8+ T cell responses are associated with delayed time to diagnosis. After stimulation of PBMC with S. Typhi-infected AEH cells (squares), S. Typhi-infected B-EBV cells (circles) or S. Typhi-infected blasts (triangles), the percentages of CD107a, IFN-γ, TNF-α, MIP-1β, IL-17A and IL-2 positive CD8+ TEM cells were plotted against time to diagnosis for each participant who developed typhoid fever (n = 7). Correlations (red lines) were assessed using the linear regression function and performed using mixed effects models to account for multiple observations per person. *p < 0.05; **p < 0.01