Fig. 6

Effects of FLP ointment on E-cadherin, N-cadherin, and Vimentin expression in the lung tissues. a Immunohistochemical analysis of E-cadherin, N-cadherin, and Vimentin expression (×200 magnification and ×100 magnification). The brown or brown yellow represented positive E-cadherin, N-cadherin, and Vimentin protein. b A representative band of E-cadherin, N-cadherin, and Vimentin protein expression by Western blot analysis. c Relative protein level of E-cadherin, N-cadherin, and Vimentin (n = 3). Values were expressed as mean ± SD. **p < 0.01, *p < 0.05, ***p < 0.001, and ****p < 0.0001. FLP Fei-Liu-Ping ointment group, C celecoxib group, FLP + C Fei-Liu-Ping ointment plus celecoxib group. FLP ointment in combination with celecoxib synergistically inhibited EMT-related E-cadherin, N-cadherin, and Vimentin protein expression in the lung metastatic inflammatory microenvironment