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Table 5 Serum cytokines concentration before and after NK cell therapy

From: Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

 

Baseline (day 0) (pg/ml)

Post administration (day 42) (pg/ml)

p value

IL-1β

4.007 ± 7.155

6.438 ± 13.22

0.25

IL-1RA

893.3 ± 2154

983.0 ± 2550

1

IL-2

37.16 ± 22.54

37.45 ± 29.48

0.8203

IL-4

2.456 ± 0.6683

2.600 ± 0.7691

0.4961

IL-5

4.029 ± 2.191

4.171 ± 3.156

1

IL-6

38.62 ± 47.26

45.43 ± 58.69

0.3594

IL-7

3.827 ± 3.984

4.724 ± 6.224

0.8203

IL-8

26.94 ± 9.571

30.73 ± 16.71

0.4258

IL-9

31.33 ± 28.77

32.87 ± 37.69

0.4258

IL-10

26.28 ± 30.72

27.71 ± 39.37

0.3008

IL-12p70

37.28 ± 50.31

47.22 ± 83.46

0.9102

IL-13

14.87 ± 21.99

19.05 ± 36.70

0.8203

IL-15

44.33 ± 20.73

43.67 ± 28.17

0.8203

IL-17

199.2 ± 89.43

185.1 ± 109.2

0.4961

IFN-γ

92.13 ± 119.4

105.4 ± 141.8

0.3594

TNF-α

32.04 ± 45.28

38.69 ± 59.64

0.0977

bFGF

51.92 ± 31.51

53.38 ± 45.84

0.7344

PDGF-BB

172.2 ± 108.3

191.0 ± 219.0

0.9102

G-CSF

55.23 ± 26.89

58.08 ± 40.79

0.9102

GM-CSF

90.58 ± 75.85

94.29 ± 97.23

0.7344

IP-10

287.1 ± 40.88

389.2 ± 204.4

0.3008

MCP-1

133.6 ± 33.18

122.1 ± 52.29

0.2031

MIP-1α

4.972 ± 3.239

4.214 ± 2.073

0.1641

MIP-1β

275.0 ± 86.68

300.6 ± 154.0

1

Eotaxin

116.4 ± 193.8

123.2 ± 233.4

0.7344

RANTES

2157 ± 396.8

2445 ± 580.7

0.2031

VEGF

92.02 ± 30.85

113.2 ± 79.16

0.9102

  1. Values are expressed as the mean ± SD. The paired t test was used to determine statistical differences
  2. NS not significant