Figure 9
Orthotopic mouse model of human meningioma generated by subdural implantation of KCI-MENG1-LPSX CL cells. Subdural implantation of cells was performed and tumors were observed with gadolinium-contrast on MRI (a 0.5 × 106 cells implanted; b 1.0 × 106 cells implanted). Harvested KCI-MENG1-LPOX tumor tissue strongly stained for PR (c), vimentin (d), and Ki-67 (e). Tumor cells expressing PR (f), vimentin (g), and Ki-67 (h) are found intermingled in the adjacent brain tissue. Scale bar 50 µm.