Volume 9 Supplement 2

6th European Workshop on Immune-Mediated Inflammatory Diseases

Open Access

CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung

  • Nicolas Glaichenhaus1,
  • Cyrille Mionnet1 and
  • Valérie Julia1
Journal of Translational Medicine20119(Suppl 2):P3

https://doi.org/10.1186/1479-5876-9-S2-P3

Published: 23 November 2011

Background

Allergic asthma is a T helper type 2 (Th2)-dominated disease of the lung. In people with asthma, a fraction of CD4-positive T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airway smooth muscle, lung endothelium and epithelium upon allergen challenge. In this study, we have investigated the role of CX3CR1/CX3CL1 in the development of allergic asthma in mice.

Results

We found that untreated CX3CR1-deficient mice or wild-type mice treated with CX3CR1-blocking reagents showed reduced lung disease upon allergen sensitization and challenge [1]. Transfer of wild-type CD4-positive T cells into CX3CR1-deficient mice restored the cardinal features of asthma, and CX3CR1-blocking reagents prevented airway inflammation in CX3CR1-deficient recipients injected with wild-type Th2 cells. We found that CX3CR1 signaling promoted Th2 survival in the inflamed lungs, and injection of B cell leukemia/lymphoma-2 protein (BCl-2)-transduced CX3CR1-deficient Th2 cells into CX3CR1-deficient mice restored asthma. CX3CR1-induced survival was also observed for Th1 cells upon airway inflammation but not under homeostatic conditions or upon peripheral inflammation.

Conclusion

CX3CR1/CX3CL1 play a critical role in the development of allergic asthma in mice making that these molecules attractive therapeutic targets in asthma.

Authors’ Affiliations

(1)
Université de Nice-Sophia Antipolis, Institut National de la Santé et de la Recherche Médicale

References

  1. Mionnet C, Buatois V, Kanda A, Milcent V, Fleury S, Lair D, Langelot M, Lacoeuille Y, Hessel E, Coffman R, Magnan A, Dombrowicz D, Glaichenhaus N, Julia V: CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nature Medicine. 2010, 16: 1305-1312. 10.1038/nm.2253.View ArticlePubMedGoogle Scholar

Copyright

© Glaichenhaus et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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