Volume 8 Supplement 1

5th European Workshop on Immune-Mediated Inflammatory Diseases

Open Access

Spondyloarthropathy and rheumatoid arthritis: two different diseases, a similar cytokine network

  • R A Moura1,
  • R Cascão1,
  • I Perpétuo1,
  • H Canhão1, 2,
  • E Vieira de Sousa1, 2,
  • A F Mourão1, 3,
  • A M Rodrigues1, 2,
  • J Polido-Pereira1, 2,
  • J A Pereira da Silva2,
  • H S Rosário4,
  • M M Souto-Carneiro5,
  • L Graca6, 7 and
  • J E Fonseca1, 2
Contributed equally
Journal of Translational Medicine20108(Suppl 1):P36

https://doi.org/10.1186/1479-5876-8-S1-P36

Published: 25 November 2010

Introduction

The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in the cytokine networks might contribute to this and may be the key to new treatment approaches.

Aim

The main goal of this work was to compare serum and synovial cytokines and chemokines in established SpA and RA patients.

Patients and methods

IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), IL-17A, IL-18, IL-21, IL-22, IL-23, IFN-γ, MCP-1, MIP-1α, OPG, sRANKL, TGF-β, TNF, APRIL and BAFF levels were measured in SpA (n=8) serum and compared with RA (n=10) and controls (n=24). Synovial fluid (SF) from SpA (n=8), RA (n=12) and osteoarthritis (OA) (n=10) patients were also analyzed.

Results

No significant differences were found between SpA and RA, with the exception of higher levels of IL-21 in the SF of RA patients.

Conclusions

Our results suggest that although SpA and RA are chronic inflammatory diseases with different clinical manifestations, both share a similar cytokine profile, including Th17-related cytokines.

Notes

Authors’ Affiliations

(1)
Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
(2)
Rheumatology Dept., Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria
(3)
Rheumatology Dept., Centro Hospitalar de Lisboa Ocidental, EPE, Hospital Egas Moniz
(4)
Microvascular Biology and Inflammation Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
(5)
Center for Neurosciences and Cell Biology, Autoimmunity Group
(6)
Cellular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
(7)
Instituto Gulbenkian de Ciência

Copyright

© Graca and Fonseca; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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