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Volume 8 Supplement 1

5th European Workshop on Immune-Mediated Inflammatory Diseases

Spondyloarthropathy and rheumatoid arthritis: two different diseases, a similar cytokine network

Journal of Translational Medicine volume 8, Article number: P36 (2010) Cite this article

Introduction

The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in the cytokine networks might contribute to this and may be the key to new treatment approaches.

Aim

The main goal of this work was to compare serum and synovial cytokines and chemokines in established SpA and RA patients.

Patients and methods

IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), IL-17A, IL-18, IL-21, IL-22, IL-23, IFN-γ, MCP-1, MIP-1α, OPG, sRANKL, TGF-β, TNF, APRIL and BAFF levels were measured in SpA (n=8) serum and compared with RA (n=10) and controls (n=24). Synovial fluid (SF) from SpA (n=8), RA (n=12) and osteoarthritis (OA) (n=10) patients were also analyzed.

Results

No significant differences were found between SpA and RA, with the exception of higher levels of IL-21 in the SF of RA patients.

Conclusions

Our results suggest that although SpA and RA are chronic inflammatory diseases with different clinical manifestations, both share a similar cytokine profile, including Th17-related cytokines.

Author information

Author notes

    Affiliations

    1. Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

      R A Moura, R Cascão, I Perpétuo, H Canhão, E Vieira de Sousa, A F Mourão, A M Rodrigues, J Polido-Pereira & J E Fonseca

    2. Rheumatology Dept., Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal

      H Canhão, E Vieira de Sousa, A M Rodrigues, J Polido-Pereira, J A Pereira da Silva & J E Fonseca

    3. Rheumatology Dept., Centro Hospitalar de Lisboa Ocidental, EPE, Hospital Egas Moniz, Lisbon, Portugal

      A F Mourão

    4. Microvascular Biology and Inflammation Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

      H S Rosário

    5. Center for Neurosciences and Cell Biology, Autoimmunity Group, Coimbra, Portugal

      M M Souto-Carneiro

    6. Cellular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

      L Graca

    7. Instituto Gulbenkian de Ciência, Oeiras, Portugal

      L Graca

    Authors
    1. R A Moura
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    2. R Cascão
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    3. I Perpétuo
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    4. H Canhão
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    5. E Vieira de Sousa
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    6. A F Mourão
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    7. A M Rodrigues
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    8. J Polido-Pereira
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    9. J A Pereira da Silva
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    10. H S Rosário
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    11. M M Souto-Carneiro
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    12. L Graca
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    13. J E Fonseca
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    Corresponding authors

    Correspondence to L Graca or J E Fonseca.

    Additional information

    R A Moura, R Cascão contributed equally to this work.

    Rights and permissions

    Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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    Cite this article

    Moura, R.A., Cascão, R., Perpétuo, I. et al. Spondyloarthropathy and rheumatoid arthritis: two different diseases, a similar cytokine network. J Transl Med 8, P36 (2010). https://doi.org/10.1186/1479-5876-8-S1-P36

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    Keywords

    • Rheumatoid Arthritis
    • Arthritis
    • Osteoarthritis
    • Clinical Manifestation
    • Rheumatoid Arthritis Patient

    Journal of Translational Medicine

    ISSN: 1479-5876

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