Volume 8 Supplement 1

5th European Workshop on Immune-Mediated Inflammatory Diseases

Open Access

Understanding the molecular bases of tissue inflammation

  • R A Flavell1
Journal of Translational Medicine20108(Suppl 1):I16

https://doi.org/10.1186/1479-5876-8-S1-I16

Published: 25 November 2010

Tissue inflammation is responsible for significant morbidity and mortality in humans. Originally thought to be restricted to acute or chronic infection or autoimmune diseases, it is becoming increasingly clear that tissue inflammation is associated with a high proportion of most chronic diseases in humans. Inflammation is a consequence of the activation of pattern recognition receptors of the innate immune response. Following their activation, effector mechanisms are triggered and adaptive immunity ensues. I will discuss the role that these pathways play with emphasis on the increasingly important contribution that is recognized for the components of the NLR inflammasome proteins. We find that these contribute to an astonishingly wide spectrum of human inflammatory diseases. As a result, therapeutic intervention in this area holds promise for treatment of human disease.

Authors’ Affiliations

(1)
Dept. of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine

Copyright

© Flavell; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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