From: Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies
PATHWAY | miRNA | TARGETED GENE | EXPRESSIONa | SOURCE | REFERENCE |
---|---|---|---|---|---|
APOPTOSIS | miR-15b | Â | up-regulated | tumors and cell lines | [122] |
 | miR-155 | NIKb (?)c, SKI (?) | down-regulated | cell lines | [63] |
CELL CYCLE | miR-193b | cyclin D1 | down-regulated | tumors | [161] |
 | miR 17-92 cluster | c-MYC | up-regulated | cell lines | |
 | miR 106-363 cluster | Rbp1-like (?) | up-regulated | cell lines | [62] |
 | miR-137 | MITF | down-regulated | cell lines | |
 | miR-182 | MITF, FOXO3 | up-regulated | tumors and cell lines | |
 | miR-221/-222 | c-KIT, p27 | up-regulated | cell lines | |
 | let-7b | cyclins A, D1, D3, CDK4 | down-regulated | tumors | |
INVASION/METASTASIS | miR-373 | Â | up-regulated | cell lines | [62] |
 | miR-137 | MITF | down-regulated | cell lines | |
 | miR-182 | MITF, FOXO3 | up-regulated | tumors and cell lines | |
 | let-7a | ITGB3 | down-regulated | cell lines | [61] |
 | miR-34b | MET | down-regulated | cell lines | [66] |
 | miR-34c | MET | down-regulated | cell lines | [66] |
 | miR-199a* | MET | down-regulated | cell lines | [66] |
TBDd | miR-17-5p | Â | up-regulated | tumors and cell lines | |
 | miR-146a |  | down-regulated | cell lines | [63] |
 | miR-146b |  | down-regulated | cell lines | [63] |
 | miR-16 |  | up-regulated | tumors | [161] |
 | miR-21 |  | up-regulated | tumors | [161] |
 | miR-22 |  | up-regulated | tumors | [161] |
 | miR-106b |  | up-regulated | tumors | [161] |
 | miR-125b |  | down-regulated | tumors | [161] |
 | miR-200c |  | down-regulated | tumors | [161] |
 | miR-203 |  | down-regulated | tumors | [161] |
 | miR-204 |  | down-regulated | tumors | [161] |
 | miR-205 |  | down-regulated | tumors | [161] |
 | miR-211 |  | down-regulated | tumors | [161] |
 | miR-214 |  | down-regulated | tumors | [161] |
 | miR-768-3p |  | down-regulated | tumors | [161] |