Figure 2
From: Main roads to melanoma
Notch1 pathway. The diagram shows the mechanism of activation of the Notch receptor by a cell-cell interaction through specific trasmembrane ligands, followed by the translation of the intracellular domain of the Notch-1 receptor (NICD) and formation of a transcription-activating multimeric complex. CSL, citrate synthase like; HAT, histone acetyltransferase; MAML, mastermind-like protein; SKIP, Skeletal muscle and kidney-enriched inositol phosphatase.