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Table 2 Percent Inhibition of monocyte internalization of AL488-MCP-1 with a CCR2 inhibitor

From: Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist

CCR2 inhibitior (μg/ml) Vol A Vol B Vol C Vol D Average Stdev %CV
555.560 96.50 95.48 95.49 95.16 95.66 0.58 0.61
185.187 95.51 95.44 94.25 94.53 94.93 0.64 0.67
61.729 92.82 92.76 92.64 93.63 92.96 0.45 0.49
20.576 90.89 91.16 90.10 90.00 90.54 0.58 0.64
6.859 84.82 86.28 85.47 86.23 85.70 0.69 0.81
2.286 78.30 76.71 81.54 79.55 79.03 2.04 2.58
0.762 71.21 75.22 71.71 69.85 72.00 2.29 3.18
0.254 59.49 67.06 62.80 59.43 62.20 3.61 5.80
0.085 43.23 57.00 49.56 47.31 49.28 5.78 11.73
0.028 31.18 38.57 36.08 35.06 35.22 3.07 8.72
0.009 23.76 24.64 21.35 24.84 23.65 1.60 6.77
0.005 13.81 15.68 11.31 13.44 13.56 1.79 13.22
  1. Based on MESF values