Table 1 Chromosomal translocation and fusion gene in bone and soft tissue sarcoma
From: A quest for therapeutic antigens in bone and soft tissue sarcoma
Tumor | Choromosomal translocation | Fusion gene | Frequency |
|---|---|---|---|
Synovial sarcoma | t(X;18)(p11.2;q11.2) | SYT-SSX1 | >60% |
| Â | Â | SYT-SSX2 | 35% |
| Â | Â | SYT-SSX4 | rare |
Ewing sarcoma | t(11;22)(q24;q12) | EWS-FLI1 | 85% |
|  | t(21;22)(q22;q12) | EWS-ERG | 5–10% |
| Â | t(7;22)(q22;q12) | EWS-ETV1 | rare |
| Â | t(17;22)(q12;q12) | EWS-E1AF | rare |
| Â | t(2;22)(q33;q12) | EWS-FEV | rare |
Alveolar rhabdomyosarcoma | t(2;13)(q35;q14) | PAX3-FKHR | >75% |
|  | t(1;13)(q36;q14) | PAX7-FKHR | 10–15% |
Myxoid liposarcoma | t(12;16)(q13:q11) | TLS-CHOP | >75% |
Clear cell sarcoma | t(12;22)(q13;q12) | EWS-ATF1 | >80% |
Dermatofibrosarcoma protuberans | t(17;22)(q22;q13) | COL1A1-PDGFb | >99% |