Figure 6

Co-administration of low dose of pitavastatin and irinotecan inhibited tumor growth in vivo . A) U87 tumor growth was inhibited by combination treatment but not by low dose of single drug; tumor volume and weight dramatically decreased following combination treatment when compared to control and single drug-treated groups. B) A combination of low dose pitavastatin and irinotecan showed no toxicity whereas high dose irinotecan induced mice body weight loss. C) H&E and Ki-67 staining of control and combination treatment of in vivo U87 tumor model, showed a much lower proliferation in the tumor cells after combination treatment.