Figure 5
Down-regulation of MDR-1 (gene ABCB1) predicted better survive for GBM patients. A) Oncoprint mRNA expression map generated using cBio Cancer Genomics. 22% of a total of 243 GBM patients showed down-regulated MDR-1 (ABCB1) expression B) Down-regulation of MDR-1 (red-line) increases overall patient survival as the median survival (blue-line) increased from 14.1 months to 23.2 months in Kaplan-Meier curves (P < 0.05) and patients’ median progression-free survival increased from 6.67 to 11.54 months (P = 0.13).