Table 1 Summary of structure of MHC class I molecules and their receptors
From: HLA-dependent tumour development: a role for tumour associate macrophages?
MHC class I | CELL TYPE | Beta2 microglobulin associated form/RECEPTORS | Open conformer form/RECEPTORS | ||
|---|---|---|---|---|---|
HLA A, B | Nearly all cells | +++ | ILT2 ILT4 KIR3DL1/2 | +/− | |
Tumor cells | +++/++/+ | ILT2 ILT4 KIR3DL1/2 | +++/++/+ | ILT4 KIR3DL1/2 | |
TAMs | ? | Â | ? | ||
HLA C | Nearly all cells | + | ILT2 ILT4 KIR2DL1/2/3 | +/− | |
Activated immune cells | +/− |  | +++ | ILT4 LILRA KIR2DL1/2/3 | |
Tumor cells (melanoma) | +/− |  | +++ | ILT4 LILRA KIR2DL1/2/3 | |
TAMs | ? | Â | ? | Â | |
HLA G | Fetal derived placental cells | +++ | ILT2 ILT4 KIR2DL4 | ? | Â |
Tumor cells (colorectal/laryngeal, ovarian/breast carcinoma, lymphoma, glioma, melanoma) | + | Â | +++ (monomer/ dimer/trimer) | ILT4 KIR2DL4 | |
TAMs | + | Â | +++ (monomer/ dimer/trimer) | ILT4 KIR2DL4 | |
HLA E | Extravillous trophoblast cells | +++ (MHC-I derived peptide) | NKG2A | ? | Â |
Endothelial and immune cells | +++ (MHC-I derived peptide) | NKG2A | ? | Â | |
Tumor cells | +++ (self peptide) | NKG2A | ? | Â | |
TAMs | +++ (self peptide) | NKG2A | ? | Â | |
HLA F | Resting immune cells | - | Â | - | Â |
Activated immune cells | +++ | ILT2 ILT4 | +++ | ILT2 ILT4 | |
Tumor cells (NSLC and esophageal carcinoma) | +++ | ILT2 ILT4 | +++ | ILT2 ILT4 | |
TAMs | ? | Â | ? | Â | |