Skip to content

Advertisement

  • Poster presentation
  • Open Access

TRAF1/C5 locus is associated with response to anti-TNF in rheumatoid arthritis

  • Helena Canhão1,
  • Ana Rodrigues1,
  • Maria Jose Santos1,
  • Diana Carmona-Fernandes1,
  • José Costa2,
  • Helena Santos3,
  • Jaime Branco4,
  • Robert Plenge5,
  • Daniel Solomon5,
  • Jacome Armas6,
  • José António Silva7,
  • João Eurico Fonseca1 and
  • Elizabeth Karlson5
Journal of Translational Medicine201210(Suppl 3):P31

https://doi.org/10.1186/1479-5876-10-S3-P31

Published: 28 November 2012

Keywords

Rheumatoid ArthritisSingle Nucleotide PolymorphismRheumatoid Arthritis PatientSingle Nucleotide PolymorphismRisk Allele

Introduction

Some of the rheumatoid arthritis (RA) risk allele variants were related to tumor necrosis factor (TNF) signaling pathways which raised the hypothesis that they might influence the response to anti-TNF drugs.

The primary aim of our work was to investigate potential association between the HLA-DRB1 and RA risk alleles specifically selected for their relevance on RA biologic pathways with the response to anti-TNF treatment in a Southern European population using a nationwide register.

Methods

We evaluated 383 RA patients for associations between anti-TNF treatment response assessed by an absolute change in DAS28 at six months as the primary outcome, and seven single nucleotide polymorphisms (SNP). We also studied the same association taking the proportion of EULAR good responders and non responders at six months as the outcome. Univariate and multivariate linear and logistic regression analyses were performed, adjusting for clinical variables that influenced treatment response.

Results

The minor allele (G), which is the risk allele for RA susceptibility, rs3761847 SNP in the TRAF1/C5 region was associated with a poor anti-TNF treatment response either in linear (coefficient -0.24; 95% confidence interval (CI) -0.43, -0.06; p-value 0.009) and in logistic univariate (odds ratio (OR) 0.61; CI 0.41, 0.92; p-value 0.018) and multivariate regression analyses.

Associations between HLA-DRB1 or the other allele variants with the response to anti-TNF treatment were not observed.

Conclusion

The rs3761847 TRAF1/C5 risk RA locus influenced the anti-TNF treatment response in the Southern European population assessed in this study. Additional studies in other populations are necessary to confirm the relevance of this finding.

Authors’ Affiliations

(1)
Rheumatology Research Unit, Instituto Medicina Molecular, Lisbon, Portugal
(2)
Rheumatology Dept., Unidade Saúde Alto Minho, PonteLima, Portugal
(3)
Instituto Português Reumatologia, Lisbon, Portugal
(4)
CEDOC, Lisbon, Portugal
(5)
Division of Rheumatology, Brigham and Women's Hospital, Boston, USA
(6)
SEEBMO, Azores, Portugal
(7)
Rheumatology Dept., Centro Hospitalar Universidade Coimbra, Coimbra, Portugal

Copyright

© Canhão et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement