Cardiovascular disease (CVD)-miRNAs | Tumor-promoting effect | ||||||
---|---|---|---|---|---|---|---|
miRNA | Sourcea | Expression in Change | Pathology | References | Tumor | Target in tumor tissue | References |
miR-16 | Circulation | ↑,↓ | ICM, AS, CAM | LUAD, HCC NSCLC | TFAP2A/PSG9/TGF-β LDH-A/lactate/NF-κB | ||
miR-19a | Circulation | ↑ | AMI, CAD | GC, HCC GC UC ccRCC | PTEN/PI3K/AKT SMAD2/Wnt/β-catenin Bim—apoptosis PTEN/SMAD4 | ||
miR-19b | Circulation | ↑ | HF, AMI, AS | NSCLC CRC | BCL2L11/PPP2R5E SMAD4, Bim—apoptosis | ||
miR-21 | Circulation | ↑ | ASO, CAD, HF, AMI | UC, HCC, NSCLC, CRC, GBM, ccRCC CRC RCC PC | PTEN/PI3K/AKT PTEN/Akt/IKKβ PTEN/Akt/NF-ĸB p53/p21-cyclin E2-Bax/caspase-3 FASL | ||
miR-25 | Circulation | ↑ | HF | TNBC, RBM, BC, HCC CCA | BTG2/AKT/ERK/MAPK PTEN/AKT, MEK4/JNK1 TRAIL | ||
miR-27a | Circulation | ↑ | CAD, HF, AMI | RCC NSCLC GC TNBC | TXNIP SMAD2/SMAD4 PHLPP2/AKT GSK-3β/Wnt/β-catenin | ||
miR-29a | Circulation | ↑ | HCM, CHD | AB | CTNNBIP1/Wnt/β-catenin | [192] | |
miR-30d | Circulation | ↑ | HF, AMI | PC | MYPT1/c-JUN/VEGFA | [168] | |
miR-92a | Circulation | ↑ | CAD, CAV | HCC, NSCLC SCCOT OC CRC | PTEN/PI3K/AKT DKK1/ Wnt/β-catenin PTEN | ||
miR-92b | Circulation | ↑ | HF, CAD, PH | GC SCLC, GBM | DAB2IP/PI3K/AKT PTEN/AKT | ||
miR-106b | Circulation | ↑ | CAD, HF | BC, CRC HCC CRC ccRCC | PTEN/PI3K/AKT GPM6A/DYNC1I1/AKT/ERK p21 TRIM8/p21 | ||
miR-126 | Circulation | ↓,↑ | AMI, AS, IHD, SA, UA | ccRCC BALL | SLC7A5/mTOR-HIF p53 | ||
miR-130b | Circulation | ↑ | MI/R, RCVS | BC, OS, RCC ES ccRCC NSCLC | PTEN, PTEN/AKT ARHGAP1/CDC42/PAK1/AP1 WNK, TCF4 PTEN/Wnt-β-catenin | ||
miR-133a | Circulation | ↓,↑ | CAD, ACS, AMI | OS OC | Bcl-xL/Mcl-1 PYGB/Wnt-β-catenin | ||
miR-146a | Circulation | ↑,↓ | AMI, ACS, HF, CAD | NSCLC | TRAF6/NF-ĸB/p65 | [135] | |
miR-146b | Circulation | ↑ | MI, PH, HF | TC BC ccRCC | PTEN/PI3K/AKT AUF1/ETS2/MMP2 TRIM2, TRAF6 | ||
miR-150 | Circulation | ↓,↑ | PH, HF, AMI | NSCLC | FOXO4/NF-ĸB/Snail | [132] | |
miR-155 | Circulation | ↑ | AS, DCM | MM ccRCC BC CRC | SOCS1/JAK2/STAT3 IGF1R/PI3K/AKT RKIP PPP2CA/AKT/NF-κB | ||
miR-208 | Circulation | ↑ | CAD, ACS, AMI | PC HCC | E-Cadherin/PI3K/AKT/ GSK-3β ARID2/IFITM1 | ||
miR-200a | Circulation | ↑ | HCM, SCA | BC | Dicer/miR-16/JNK2/MMP-2 axis | [211] | |
miR-210 | Circulation | ↑ | PH, HF, CAD | PC NSCLC OC | OCS1/TNIP1/p65/NF-κB UPF1/PTEN/PI3K/AKT EphrinA3-PI3K/AKT | ||
miR-223 | Circulation | ↑ | AS, AMI, SC, AD | ccRCC | SLC4A4, HIF-2α | ||
miR-423 | Circulation | ↑ | AMI, HF | GBM PC BC | ING-4/AKT/ERK GREM2/TGF-β, CREBZF TNIP2/NF-ĸB | ||
miR-451 | Circulation | ↓ | PH, AMI | ccRCC | PSMB8 |