Fig. 5

Cardio-miRNAs regulate tumor cells adaptive progression through the NF-κB signaling pathway. Bold black indicates key node protein factors involved in the pathway; bold red letters indicate Cardio-miRNAs. (The red bold represents circulation-derived exosomes Cardio-miRNAs, which may be upregulated in tumor cells; solid black arrows indicate promotion or activation; line segment indicate inhibition; dashed arrows indicate multi-step transfers or activation; white corner arrows indicate gene transcription expression)