Fig. 4

Cardio-miRNAs regulate tumor cells adaptive progression through the Wnt/β-Catein signaling pathway. Bold white indicates key node protein factors involved in the pathway; Bold red letters indicate Cardio-miRNAs. (The red bold represents circulation-derived exosomes Cardio-miRNAs, which may be upregulated in tumor cells; solid black arrows indicate promotion or activation; Line segment indicate inhibition; dashed arrows indicate multi-step transfers; White corner arrows indicate gene transcription expression)