Fig. 3

Cardio-miRNAs regulate tumor cells adaptive progression through the PTEN/PI3K/AKT signaling pathway. Bold black indicates key node protein factors involved in the pathway; Bold red letters indicate Cardio-miRNAs. (The red bold represents circulation-derived exosomes Cardio-miRNAs, which may be upregulated in tumor cells; solid arrows indicate promotion or activation; Line segment indicate inhibition)