Fig. 5

Oxaliplatin induces change in morphology and re-expression of digestive enzymes. a H&E depicted morphological changes and increased cell size in PA-018 after oxaliplatin treatment on endpoint tumor sections. There was also cytoplasmic retention of the digestive enzymes, amylase and lipase. Representative IHC was shown for placebo and oxaliplatin groups. Inlays are normal human pancreas. b Cytoplasmic amylase and lipase were quantitated by positive pixel count over area and plotted as mean ± standard deviation. **P < 0.01 for treatment group as compared to placebo, n = 5