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Table 2 Association between RBM3 expression and clinicopathological parameters

From: Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study

 

RBM3 staining intensity

 

0-2

3

 

n(%)

95 (44.2)

120 (55.8)

p-value

Age

   

Mean

68.00

67.15

0.673

(range)

(47-83)

(46-81)

 

Gender

   

Female

45(47.4)

63(52.5)

0.457

Male

50(52.6)

57(47.5)

 

Clark level

   

II

21(22.3)

50(42.4)

0.005**

IIII

48(51.1)

46(39.0)

 

IV-V

25(26.6)

22(18.6)

 

missing

1

2

 

Breslow(mm)

   

Mean

2.47

1.12

0.001**

(range)

(0.08-40.00)

(0.11-7.00)

 

Ulceration

   

No

71(74.7)

109(91.6)

0.001**

Yes

24(25.3)

10(8.4)

 

missing

0

1

 

Lymphocytic

   

infiltrate

   

0-1

26(27.4)

34(28.6)

0.846

2-3

69(72.6)

85(71.4)

 

missing

0

1

 

Clinical stage

   

I

54(76.1)

95(91.3)

0.005*

II-IV

17(23.9)

9(8.7)

 

missing

24

16

 

Vascular invasion

   

No

87(91.6)

114(95.0)

0.314

Yes

8(8.4)

6(5.0)

 

Localization

   

Head and neck

15(16.0)

16(14.0)

0.352

Extremities

40(42.6)

59(51.8)

 

Frontal thorax

10(10.6)

15(13.2)

 

Dorsal thorax

29(30.9)

24(21.1)

 

missing

1

6

 

Type

   

SSM, LMM, Other

65(58.9)

97(68.9)

0.027*

NMM

30(31.6)

22(18.5)

 

missing

0

1

 

Mitotic count

   

< 1/mm2

34(35.8)

71(59.2)

0.001**

> = 1/mm2

61(64.2)

49(40.8)

 
  1. *Significant at the 0.05 level
  2. ** Significant at the 0.01 level
  3. § Mann Whitney U test for comparison of means
  4. SSM = Superficial spreading melanoma
  5. NMM = Nodular malignant melanoma
  6. LMM = Lentigo malignant melanoma