Figure 5
Immune suppressive microenvironment can partially be reverted with aATC immunotherapy. A schematic summary of the present study showing high levels of COX2/PGE2/ARG1 in the tumor microenvironment, which promote tumor growth and MDSC development and maintain immune suppressive microenvironment inhibiting proliferation and activation of T cells and NK cells. aATC induced Th1 cytokines may inhibit the tumor- and MDSC-derived immunosuppressive factors COX2, PGE2, ARG1 and IL-6 in the tumor microenvironment and may restore the immune activating microenvironment.