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Table 4 Hazard ratios of CRC risk defined by different tumour characteristics in relation to height, weight and hip circumference in men

From: Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study

Tumour characteristics

Quartiles

Height

Weight

Hip

Number of cases

 

Cases

RR

Cases

RR

Cases

RR

Positive nuclear beta-catenin

1

40

1.00

29

1.00

26

1.00

2

36

0.97(0.61-1.55)

42

1.41(0.86-2.29)

33

1.28(0.76-2.18)

3

33

0.71(0.44-1.14)

35

1.15(0.69-1.93)

45

1.55(0.93-2.57)

4

42

1.15(0.73-1.81)

45

1.53(0.94-2.49)

47

1.39(0.84-2.30)

 

p trend

 

0.877

 

0.180

 

0.182

Negative nuclear beta-catenin

1

14

1.00

19

1.00

17

1.00

2

26

2.13(1.09-4.16)

19

1.02(0.53-1.94)

11

0.65(0.30-1.40)

3

32

1.94(1.00-3.75)

26

1.31(0.71-2.43)

33

1.87(1.02-3.42)

4

27

1.90(0.96-3.79)

35

1.70(0.94-3.07)

38

1.46(0.79-2.70)

 

p trend

 

0.122

 

0.048

 

0.036

CyclinD1 positive

1

45

1.00

40

1.00

36

1.00

2

46

1.16(0.76-1.77)

49

1.23(0.80-1.89)

32

0.91(0.56-1.48)

3

53

1.02(0.67-1.54)

44

1.08(0.69-1.68)

61

1.57(1.02-2.41)

4

52

1.25(0.82-1.90)

63

1.57(1.04-2.39)

67

1.38(0.90-2.12)

 

p trend

 

0.442

 

0.058

 

0.034

CyclinD1 negative

1

10

1.00

8

1.00

7

1.00

2

15

1.48(0.66-3.34)

12

1.39(0.57-3.42)

12

1.65(0.65-4.21)

3

13

1.00(0.43-2.32)

17

1.85(0.79-4.34)

16

2.12(0.87-5.18)

4

17

1.52(0.68-3.43)

18

1.78(0.76-4.22)

20

1.90(0.78-4.62)

 

p trend

 

0.513

 

0.151

 

0.159

p53 positive (>50%)

1

22

1.00

20

1.00

15

1.00

2

32

1.64(0.93-2.90)

26

1.27(0.70-2.30)

22

1.48(0.76-2.90)

3

32

1.31(0.74-2.31)

33

1.42(0.79-2.54)

38

2.29(1.23-4.26)

4

33

1.65(0.93-2.92)

40

1.85(1.06-3.23)

44

2.12(1.14-3.92)

 

p trend

 

0.191

 

0.026

 

0.009

P53 negative (<50%)

1

32

1.00

27

1.00

27

1.00

2

30

1.02(0.62-1.70)

36

1.33(0.79-2.22)

22

0.82(0.46-1.46)

3

33

0.84(0.51-1.39)

27

1.06(0.61-1.83)

39

1.36(0.82-2.27)

4

36

1.13(0.68-1.87)

41

1.48(0.88-2.48)

43

1.15(0.69-1.91)

 

p trend

 

0.845

 

0.251

 

0.288

MSI

1

5

1.00

4

1.00

5

1.00

2

9

2.07(0.69-6.20)

7

1.76(0.51-6.05)

5

0.94(0.27-3.26)

3

5

0.98(0.28-3.42)

7

1.91(0.55-6.60)

6

1.06(0.32-3.51)

4

8

1.79(0.55-5.77)

9

2.36(0.70-7.96)

11

1.45(0.49-4.32)

 

p trend

 

0.630

 

0.176

 

0.431

MSS

1

48

1.00

46

1.00

39

1.00

2

51

1.16(0.77-1.74)

51

1.09(0.73-1.65)

39

1.03(0.65-1.61)

3

59

1.02(0.69-1.53)

52

1.07(0.71-1.62)

64

1.54(1.02-2.33)

4

58

1.25(0.83-1.87)

67

1.38(0.93-2.05)

74

1.40(0.93-2.11)

 

p trend

 

0.411

 

0.126

 

0.038

  1. Adjusted for age, level of education, smoking habits and alcohol consumption.