Fig. 7

The schematic representation of the mechanisms by which CAV3 downregulation exacerbates diabetic cardiomyopathy via inducing NDUFA10-mediated mitochondrial dysfunction in diabetes. CAV3 expression is decreased in cardiomyocytes under diabetic conditions. Downregulation of CAV3 leads to the downregulation of NDUFA10, which is degraded via the lysosomal pathway. Consequently, the reduction of NDUA10 in mitochondria lead to a decrease in the mitochondrial complex I activity, resulting in mitochondrial dysfunction. As a result, ATP production decreases, mitochondrial ROS levels increase and cell apoptosis occurs, thereby leading to cardiac dysfunction