Fig. 3

FUS::DDIT3-induced gene expression signatures in myxoid liposarcoma scaffolds. A Principal component analysis of transcriptional profiles for HT1080 wild-type (WT), HT1080 eGFP and HT1080 FUS::DDIT3-eGFP cells cultured in either myxoid liposarcoma (MLS) scaffolds or monolayers. n = 3–5. B Venn diagram showing gene regulation overlap between HT1080 WT, HT1080 eGFP, and HT1080 FUS::DDIT3-eGFP cells cultured in MLS scaffolds. C Functional enrichment analysis using the 713 FUS::DDIT3-regulated genes using GO biological processes, Reactome and Chemical and genetic perturbations gene set collections. Top 5 categories are shown based on q-value. Size of dots indicate gene count