Table 1 Groups of collagen receptors
From: Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
Receptors | Expression | Function upon binding collagen |
|---|---|---|
Integrins | All cells | Regulation of cell adhesion [29] |
Discoidin domain Receptor family | Epithelial cells and mesenchymal cells | Regulation of cell migration, differentiation, proliferation, survival, ECM remodeling [30] |
Mannose receptor family | Macrophages and fibroblasts | Endocytosis of collagen for lysomal degradation [31] |
Glycoprotein VI | Platelets | Platelet activation [32] |
Osteoclast-associated receptor | Osteoclasts, myeloid cells | Osteoclast differentiation, Monocyte survival [33] |
Leukocyte Associated Immunoglobulin Like Receptor 1 | Immune cells | Inhibition of immune cell activity [34] |